Pre-diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed tomography
Abstract The volume of epicardial adipose tissue (EATV) is increased in type-2 diabetes (T2D), while its attenuation (EATA) appears to be decreased. Similar patterns have been suggested in pre-diabetes, but data is scarce. In both pre-diabetes and T2D, any independent role of EATV and EATA in diseas...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28679-w |
| _version_ | 1811175887006072832 |
|---|---|
| author | David Molnar Elias Björnson Måns Larsson Martin Adiels Anders Gummesson Fredrik Bäckhed Ola Hjelmgren Göran Bergström |
| author_facet | David Molnar Elias Björnson Måns Larsson Martin Adiels Anders Gummesson Fredrik Bäckhed Ola Hjelmgren Göran Bergström |
| author_sort | David Molnar |
| collection | DOAJ |
| description | Abstract The volume of epicardial adipose tissue (EATV) is increased in type-2 diabetes (T2D), while its attenuation (EATA) appears to be decreased. Similar patterns have been suggested in pre-diabetes, but data is scarce. In both pre-diabetes and T2D, any independent role of EATV and EATA in disease development remains to be proven, a task complicated by their substantial co-variation with other anthropometrics, e.g. BMI, waist circumference, and abdominal visceral adipose tissue (VAT). EATV and EATA was quantified in computed tomography (CT) images in a population study (n = 1948) using an automatic technique. Data was available on BMI, waist circumference, abdominal visceral adipose tissue (VAT) area, insulin resistance (IR) and glucose tolerance, the latter ranging from normal (NGT), over pre-diabetes (impaired fasting glucose [IFG, n = 414] impaired glucose tolerance [IGT, n = 321] and their combination [CGI, n = 128]), to T2D. EATV was increased in pre-diabetes, T2D and IR in univariable analyses and when adjusting for BMI, however not when adjusting for waist or VAT. EATA was reduced in pre-diabetes, T2D and IR in univariable analyses and when adjusting for BMI and waist, however not when adjusting for VAT. Adjustment for other co-variates had little influence on the results. In conclusion, EATV is increased and EATA reduced in pre-diabetes, T2D and IR, however, significant co-variation with other anthropometrics, especially VAT, obscures their function in disease development. The current results do not exclude a pathophysiological role of epicardial fat, but future studies need to adjust for anthropometrics, or focus on the microenvironment within the pericardial sac. |
| first_indexed | 2024-04-10T19:44:17Z |
| format | Article |
| id | doaj.art-8d5489de06ee4073b1902f8e79a27cff |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T19:44:17Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8d5489de06ee4073b1902f8e79a27cff2023-01-29T12:08:56ZengNature PortfolioScientific Reports2045-23222023-01-0113111210.1038/s41598-023-28679-wPre-diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed tomographyDavid Molnar0Elias Björnson1Måns Larsson2Martin Adiels3Anders Gummesson4Fredrik Bäckhed5Ola Hjelmgren6Göran Bergström7Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgEigenvision ABSahlgrenska Academy, and School of Public Health and Community Medicine, Institute of Medicine, University of GothenburgDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgAbstract The volume of epicardial adipose tissue (EATV) is increased in type-2 diabetes (T2D), while its attenuation (EATA) appears to be decreased. Similar patterns have been suggested in pre-diabetes, but data is scarce. In both pre-diabetes and T2D, any independent role of EATV and EATA in disease development remains to be proven, a task complicated by their substantial co-variation with other anthropometrics, e.g. BMI, waist circumference, and abdominal visceral adipose tissue (VAT). EATV and EATA was quantified in computed tomography (CT) images in a population study (n = 1948) using an automatic technique. Data was available on BMI, waist circumference, abdominal visceral adipose tissue (VAT) area, insulin resistance (IR) and glucose tolerance, the latter ranging from normal (NGT), over pre-diabetes (impaired fasting glucose [IFG, n = 414] impaired glucose tolerance [IGT, n = 321] and their combination [CGI, n = 128]), to T2D. EATV was increased in pre-diabetes, T2D and IR in univariable analyses and when adjusting for BMI, however not when adjusting for waist or VAT. EATA was reduced in pre-diabetes, T2D and IR in univariable analyses and when adjusting for BMI and waist, however not when adjusting for VAT. Adjustment for other co-variates had little influence on the results. In conclusion, EATV is increased and EATA reduced in pre-diabetes, T2D and IR, however, significant co-variation with other anthropometrics, especially VAT, obscures their function in disease development. The current results do not exclude a pathophysiological role of epicardial fat, but future studies need to adjust for anthropometrics, or focus on the microenvironment within the pericardial sac.https://doi.org/10.1038/s41598-023-28679-w |
| spellingShingle | David Molnar Elias Björnson Måns Larsson Martin Adiels Anders Gummesson Fredrik Bäckhed Ola Hjelmgren Göran Bergström Pre-diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed tomography Scientific Reports |
| title | Pre-diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed tomography |
| title_full | Pre-diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed tomography |
| title_fullStr | Pre-diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed tomography |
| title_full_unstemmed | Pre-diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed tomography |
| title_short | Pre-diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed tomography |
| title_sort | pre diabetes is associated with attenuation rather than volume of epicardial adipose tissue on computed tomography |
| url | https://doi.org/10.1038/s41598-023-28679-w |
| work_keys_str_mv | AT davidmolnar prediabetesisassociatedwithattenuationratherthanvolumeofepicardialadiposetissueoncomputedtomography AT eliasbjornson prediabetesisassociatedwithattenuationratherthanvolumeofepicardialadiposetissueoncomputedtomography AT manslarsson prediabetesisassociatedwithattenuationratherthanvolumeofepicardialadiposetissueoncomputedtomography AT martinadiels prediabetesisassociatedwithattenuationratherthanvolumeofepicardialadiposetissueoncomputedtomography AT andersgummesson prediabetesisassociatedwithattenuationratherthanvolumeofepicardialadiposetissueoncomputedtomography AT fredrikbackhed prediabetesisassociatedwithattenuationratherthanvolumeofepicardialadiposetissueoncomputedtomography AT olahjelmgren prediabetesisassociatedwithattenuationratherthanvolumeofepicardialadiposetissueoncomputedtomography AT goranbergstrom prediabetesisassociatedwithattenuationratherthanvolumeofepicardialadiposetissueoncomputedtomography |