Nationwide Surveillance of Antifungal Resistance of <i>Candida</i> Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS
We incorporated nationwide <i>Candida</i> antifungal surveillance into the Korea Global Antimicrobial Resistance Surveillance System (Kor-GLASS) for bacterial pathogens. We prospectively collected and analyzed complete non-duplicate blood isolates and information from nine sentinel hospi...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/10/996 |
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| author | Eun Jeong Won Min Ji Choi Seok Hoon Jeong Dokyun Kim Kyeong Seob Shin Jeong Hwan Shin Young Ree Kim Hyun Soo Kim Young Ah Kim Young Uh Namhee Ryoo Jeong Su Park Kyoung Un Park Seung A. Byun Ga Yeong Lee Soo Hyun Kim Jong Hee Shin |
| author_facet | Eun Jeong Won Min Ji Choi Seok Hoon Jeong Dokyun Kim Kyeong Seob Shin Jeong Hwan Shin Young Ree Kim Hyun Soo Kim Young Ah Kim Young Uh Namhee Ryoo Jeong Su Park Kyoung Un Park Seung A. Byun Ga Yeong Lee Soo Hyun Kim Jong Hee Shin |
| author_sort | Eun Jeong Won |
| collection | DOAJ |
| description | We incorporated nationwide <i>Candida</i> antifungal surveillance into the Korea Global Antimicrobial Resistance Surveillance System (Kor-GLASS) for bacterial pathogens. We prospectively collected and analyzed complete non-duplicate blood isolates and information from nine sentinel hospitals during 2020–2021, based on GLASS early implementation protocol for the inclusion of <i>Candida</i> species. <i>Candida</i> species ranked fourth among 10,758 target blood pathogens and second among 4050 hospital-origin blood pathogens. Among 766 <i>Candida</i> blood isolates, 87.6% were of hospital origin, and 41.3% occurred in intensive care unit patients. Adults > 60 years of age accounted for 75.7% of cases. Based on species-specific clinical breakpoints, non-susceptibility to fluconazole, voriconazole, caspofungin, micafungin, and anidulafungin was found in 21.1% (154/729), 4.0% (24/596), 0.1% (1/741), 0.0% (0/741), and 0.1% (1/741) of the isolates, respectively. Fluconazole resistance was determined in 0% (0/348), 2.2% (3/135, 1 Erg11 mutant), 5.3% (7/133, 6 Pdr1 mutants), and 5.6% (6/108, 4 <i>Erg11</i> and 1 <i>Cdr1</i> mutants) of <i>C. albicans, C. tropicalis, C. glabrata</i>, and <i>C. parapsilosis</i> isolates, respectively. An echinocandin-resistant <i>C. glabrata</i> isolate harbored an F659Y mutation in Fks2p. The inclusion of <i>Candida</i> species in the Kor-GLASS system generated well-curated surveillance data and may encourage global <i>Candida</i> surveillance efforts using a harmonized GLASS system. |
| first_indexed | 2024-03-09T20:00:08Z |
| format | Article |
| id | doaj.art-8d551899dadb40a0a078a8f4f309da32 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T20:00:08Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-8d551899dadb40a0a078a8f4f309da322023-11-24T00:46:26ZengMDPI AGJournal of Fungi2309-608X2022-09-0181099610.3390/jof8100996Nationwide Surveillance of Antifungal Resistance of <i>Candida</i> Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASSEun Jeong Won0Min Ji Choi1Seok Hoon Jeong2Dokyun Kim3Kyeong Seob Shin4Jeong Hwan Shin5Young Ree Kim6Hyun Soo Kim7Young Ah Kim8Young Uh9Namhee Ryoo10Jeong Su Park11Kyoung Un Park12Seung A. Byun13Ga Yeong Lee14Soo Hyun Kim15Jong Hee Shin16Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Laboratory Medicine, Chungbuk National University College of Medicine, Cheongju 28644, KoreaDepartment of Laboratory Medicine, Paik Institute for Clinical Research, Inje University College of Medicine, Busan 47392, KoreaDepartment of Laboratory Medicine, Jeju National University Medical School, Jeju 63243, KoreaDepartment of Laboratory Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, KoreaDepartment of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang 10444, KoreaDepartment of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, KoreaDepartment of Laboratory Medicine, Keimyung University School of Medicine, Daegu 42601, KoreaDepartment of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Laboratory Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaWe incorporated nationwide <i>Candida</i> antifungal surveillance into the Korea Global Antimicrobial Resistance Surveillance System (Kor-GLASS) for bacterial pathogens. We prospectively collected and analyzed complete non-duplicate blood isolates and information from nine sentinel hospitals during 2020–2021, based on GLASS early implementation protocol for the inclusion of <i>Candida</i> species. <i>Candida</i> species ranked fourth among 10,758 target blood pathogens and second among 4050 hospital-origin blood pathogens. Among 766 <i>Candida</i> blood isolates, 87.6% were of hospital origin, and 41.3% occurred in intensive care unit patients. Adults > 60 years of age accounted for 75.7% of cases. Based on species-specific clinical breakpoints, non-susceptibility to fluconazole, voriconazole, caspofungin, micafungin, and anidulafungin was found in 21.1% (154/729), 4.0% (24/596), 0.1% (1/741), 0.0% (0/741), and 0.1% (1/741) of the isolates, respectively. Fluconazole resistance was determined in 0% (0/348), 2.2% (3/135, 1 Erg11 mutant), 5.3% (7/133, 6 Pdr1 mutants), and 5.6% (6/108, 4 <i>Erg11</i> and 1 <i>Cdr1</i> mutants) of <i>C. albicans, C. tropicalis, C. glabrata</i>, and <i>C. parapsilosis</i> isolates, respectively. An echinocandin-resistant <i>C. glabrata</i> isolate harbored an F659Y mutation in Fks2p. The inclusion of <i>Candida</i> species in the Kor-GLASS system generated well-curated surveillance data and may encourage global <i>Candida</i> surveillance efforts using a harmonized GLASS system.https://www.mdpi.com/2309-608X/8/10/996candidemia<i>Candida</i> speciesantifungal surveillanceGLASS |
| spellingShingle | Eun Jeong Won Min Ji Choi Seok Hoon Jeong Dokyun Kim Kyeong Seob Shin Jeong Hwan Shin Young Ree Kim Hyun Soo Kim Young Ah Kim Young Uh Namhee Ryoo Jeong Su Park Kyoung Un Park Seung A. Byun Ga Yeong Lee Soo Hyun Kim Jong Hee Shin Nationwide Surveillance of Antifungal Resistance of <i>Candida</i> Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS Journal of Fungi candidemia <i>Candida</i> species antifungal surveillance GLASS |
| title | Nationwide Surveillance of Antifungal Resistance of <i>Candida</i> Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS |
| title_full | Nationwide Surveillance of Antifungal Resistance of <i>Candida</i> Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS |
| title_fullStr | Nationwide Surveillance of Antifungal Resistance of <i>Candida</i> Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS |
| title_full_unstemmed | Nationwide Surveillance of Antifungal Resistance of <i>Candida</i> Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS |
| title_short | Nationwide Surveillance of Antifungal Resistance of <i>Candida</i> Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS |
| title_sort | nationwide surveillance of antifungal resistance of i candida i bloodstream isolates in south korean hospitals two year report from kor glass |
| topic | candidemia <i>Candida</i> species antifungal surveillance GLASS |
| url | https://www.mdpi.com/2309-608X/8/10/996 |
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