An Observational Study of Corneal Endothelial Alterations in Eyes with Unilateral Pseudoexfoliation
Introduction: Pseudoexfoliation (PXF) is an age-related generalised disorder of extracellular matrix primarily affecting eyes. It is characterised by deposition of pseudoexfoliative material in the anterior segment of eye. Also it is a bilateral condition but can have asymmetric presentation and...
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JCDR Research and Publications Private Limited
2021-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/15261/48330_CE[Ra1]_F[SK]_PF1(JY_OM)_PFA_NC_PN(KM).pdf |
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| author | ARCHANA THOOL RASHMI RAMANI PRAVIN TIDAKE |
| author_facet | ARCHANA THOOL RASHMI RAMANI PRAVIN TIDAKE |
| author_sort | ARCHANA THOOL |
| collection | DOAJ |
| description | Introduction: Pseudoexfoliation (PXF) is an age-related
generalised disorder of extracellular matrix primarily affecting
eyes. It is characterised by deposition of pseudoexfoliative
material in the anterior segment of eye. Also it is a bilateral
condition but can have asymmetric presentation and clinically
can be seen only in one eye. Alteration in endothelial cell
morphology along with other alteration in anterior segment of
the eye can compromise the surgical outcome.
Aim: To evaluate the corneal endothelial cell density and
morphology in patients with unilateral PXF.
Materials and Methods: The present study was hospitalbased cross-sectional observational study which included
55 patients with unilateral PXF, came to the Department of
Opthalmology, Acharya Vinoba Bhave Rural Hospital (AVBRH),
Wardha, Maharashtra, India between June 2020 to November
2020. Specular microscopy was performed in all eyes to
evaluate cell density and morphology, coefficient of variation
in cell size and percentage of hexagonal cells in corneal
endothelium and compared with fellow normal eye. Statistical
analysis was done by using descriptive and inferential statistics
using students unpaired t-test, p-value<0.05 was considered
as level of significance.
Results: The present study included 55 patients, of which 26
were males and 29 were females. Mean age of the patients
was 63.85±7.05 years. Majority of patients were in the range
of 61 to 70 years (56.36%). The mean corneal endothelial cell
density in the PXF eye was 2299.54±84.95 cells/mm2
, which
was significantly lower as compared to fellow normal eye
with p-value<0.001. Mean coefficient of variation of cell size
in PXF eye was 35.49±4.62, p-value=0.064 and hexagonality
was 51.12±4.91, p-value=0.13. Both the parameters were
statistically non significant on comparison of two eyes. Central
corneal thickness was thicker in pseudoexfoliative eye of
551.29±33.11 microns (μm), than fellow eye but was statistically
non significant.
Conclusion: Eyes with PXF had alteration in endothelial cell
morphology with decrease in cell density as compared to eyes
without PXF clinically. |
| first_indexed | 2024-12-16T07:56:38Z |
| format | Article |
| id | doaj.art-8d57ae7f726a4c58958ccd4f6920004f |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-16T07:56:38Z |
| publishDate | 2021-08-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-8d57ae7f726a4c58958ccd4f6920004f2022-12-21T22:38:42ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-08-01158NC11NC1410.7860/JCDR/2021/48330.15261An Observational Study of Corneal Endothelial Alterations in Eyes with Unilateral PseudoexfoliationARCHANA THOOL0RASHMI RAMANI1PRAVIN TIDAKE2Assistant Professor, Department of Ophthalmology, Jawharlal Nehru Medical College, Wardha, Maharashtra, India.Junior Resident, Department of Ophthalmology, Jawharlal Nehru Medical College, Wardha, Maharashtra, India.Professor, Department of Ophthalmology, Jawharlal Nehru Medical College, Wardha, Maharashtra, India.Introduction: Pseudoexfoliation (PXF) is an age-related generalised disorder of extracellular matrix primarily affecting eyes. It is characterised by deposition of pseudoexfoliative material in the anterior segment of eye. Also it is a bilateral condition but can have asymmetric presentation and clinically can be seen only in one eye. Alteration in endothelial cell morphology along with other alteration in anterior segment of the eye can compromise the surgical outcome. Aim: To evaluate the corneal endothelial cell density and morphology in patients with unilateral PXF. Materials and Methods: The present study was hospitalbased cross-sectional observational study which included 55 patients with unilateral PXF, came to the Department of Opthalmology, Acharya Vinoba Bhave Rural Hospital (AVBRH), Wardha, Maharashtra, India between June 2020 to November 2020. Specular microscopy was performed in all eyes to evaluate cell density and morphology, coefficient of variation in cell size and percentage of hexagonal cells in corneal endothelium and compared with fellow normal eye. Statistical analysis was done by using descriptive and inferential statistics using students unpaired t-test, p-value<0.05 was considered as level of significance. Results: The present study included 55 patients, of which 26 were males and 29 were females. Mean age of the patients was 63.85±7.05 years. Majority of patients were in the range of 61 to 70 years (56.36%). The mean corneal endothelial cell density in the PXF eye was 2299.54±84.95 cells/mm2 , which was significantly lower as compared to fellow normal eye with p-value<0.001. Mean coefficient of variation of cell size in PXF eye was 35.49±4.62, p-value=0.064 and hexagonality was 51.12±4.91, p-value=0.13. Both the parameters were statistically non significant on comparison of two eyes. Central corneal thickness was thicker in pseudoexfoliative eye of 551.29±33.11 microns (μm), than fellow eye but was statistically non significant. Conclusion: Eyes with PXF had alteration in endothelial cell morphology with decrease in cell density as compared to eyes without PXF clinically.https://jcdr.net/articles/PDF/15261/48330_CE[Ra1]_F[SK]_PF1(JY_OM)_PFA_NC_PN(KM).pdfcentral corneal thicknessendothelial cell morphologypseudoexfoliative materialspecular microscopy |
| spellingShingle | ARCHANA THOOL RASHMI RAMANI PRAVIN TIDAKE An Observational Study of Corneal Endothelial Alterations in Eyes with Unilateral Pseudoexfoliation Journal of Clinical and Diagnostic Research central corneal thickness endothelial cell morphology pseudoexfoliative material specular microscopy |
| title | An Observational Study of Corneal Endothelial Alterations in Eyes with Unilateral Pseudoexfoliation |
| title_full | An Observational Study of Corneal Endothelial Alterations in Eyes with Unilateral Pseudoexfoliation |
| title_fullStr | An Observational Study of Corneal Endothelial Alterations in Eyes with Unilateral Pseudoexfoliation |
| title_full_unstemmed | An Observational Study of Corneal Endothelial Alterations in Eyes with Unilateral Pseudoexfoliation |
| title_short | An Observational Study of Corneal Endothelial Alterations in Eyes with Unilateral Pseudoexfoliation |
| title_sort | observational study of corneal endothelial alterations in eyes with unilateral pseudoexfoliation |
| topic | central corneal thickness endothelial cell morphology pseudoexfoliative material specular microscopy |
| url | https://jcdr.net/articles/PDF/15261/48330_CE[Ra1]_F[SK]_PF1(JY_OM)_PFA_NC_PN(KM).pdf |
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