Macular Vascularity and Ganglion Cell Complex Parameters in the Young Adults with Myopia and Progressive Myopia
Artur Małyszczak,1 Magdalena Żyto,2 Joanna Przeździecka-Dołyk,2 Marta Misiuk-Hojło1 1Department and Clinic of Ophthalmology, Wroclaw Medical University, Wroclaw, Dolnoslaskie, Poland; 2Department of Optics and Photonics, Wroclaw University of Scie...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-02-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/macular-vascularity-and-ganglion-cell-complex-parameters-in-the-young--peer-reviewed-fulltext-article-OPTH |
| _version_ | 1811165557310881792 |
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| author | Małyszczak A Żyto M Przeździecka-Dołyk J Misiuk-Hojło M |
| author_facet | Małyszczak A Żyto M Przeździecka-Dołyk J Misiuk-Hojło M |
| author_sort | Małyszczak A |
| collection | DOAJ |
| description | Artur Małyszczak,1 Magdalena Żyto,2 Joanna Przeździecka-Dołyk,2 Marta Misiuk-Hojło1 1Department and Clinic of Ophthalmology, Wroclaw Medical University, Wroclaw, Dolnoslaskie, Poland; 2Department of Optics and Photonics, Wroclaw University of Science and Technology, Wroclaw, Dolnoslaskie, PolandCorrespondence: Artur Małyszczak, Department and Clinic of Ophthalmology, Wroclaw Medical University, Borowska 213 50-556, Wroclaw, Dolnoslaskie, Poland, Email arturm100@gmail.comPurpose: The purpose of this study is to determine the relationships between foveal avascular zone (FAZ), foveal vascular density (FD) and GCC (ganglion cell complex) parameters in a healthy myopic population using optical coherence tomography angiography (angio-OCT).Patients and Methods: Three hundred and eighty-one eyes of 381 healthy participants were included into this study and assigned to three groups according to their spherical equivalent (SE) values and an additional progressive myopia group. One randomly chosen eye from each patient was analyzed. GCC mean thickness, focal loss of volume (FLV), global loss of volume (GLV), FAZ area, FAZ perimeter, and FD parameters were obtained with the RTVue AngioOCT device.Results: FAZ area and its perimeter were strongly correlated with the belonging spherical equivalent group (p = 0.0001, p = 0.0008 accordingly), being the largest in progressive myopia subgroup (mean size 0.42mm2). Other factors that were significantly higher in myopic eyes were FLV (p = 0.0023), GLV (p = 0.0020). There were no differences in FD between groups. In the myopic and progressive myopia groups, there was a significant relationship between FAZ area and FLV, GLV, and GCC thickness. We found that in myopic eyes with AXL exceeding 26.6 mm, FAZ becomes negatively correlated to mean GCC thickness.Conclusion: In myopia, compared to non-myopic groups, there is a greater loss of neural tissue represented by a thinner GCC layer, greater FLV and GLV parameters, and worse blood supply represented by a larger FAZ area. Eye axial length of 26.6 mm is a breaking point, where the negative FAZ area to GCC thickness relationship curve is getting significantly steeper.Keywords: GCC, FAZ, optical coherence tomography angiography, OCTA |
| first_indexed | 2024-04-10T15:38:56Z |
| format | Article |
| id | doaj.art-8d581ee7decc46608c4115c9c3610823 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-04-10T15:38:56Z |
| publishDate | 2023-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-8d581ee7decc46608c4115c9c36108232023-02-12T17:45:33ZengDove Medical PressClinical Ophthalmology1177-54832023-02-01Volume 1756157081592Macular Vascularity and Ganglion Cell Complex Parameters in the Young Adults with Myopia and Progressive MyopiaMałyszczak AŻyto MPrzeździecka-Dołyk JMisiuk-Hojło MArtur Małyszczak,1 Magdalena Żyto,2 Joanna Przeździecka-Dołyk,2 Marta Misiuk-Hojło1 1Department and Clinic of Ophthalmology, Wroclaw Medical University, Wroclaw, Dolnoslaskie, Poland; 2Department of Optics and Photonics, Wroclaw University of Science and Technology, Wroclaw, Dolnoslaskie, PolandCorrespondence: Artur Małyszczak, Department and Clinic of Ophthalmology, Wroclaw Medical University, Borowska 213 50-556, Wroclaw, Dolnoslaskie, Poland, Email arturm100@gmail.comPurpose: The purpose of this study is to determine the relationships between foveal avascular zone (FAZ), foveal vascular density (FD) and GCC (ganglion cell complex) parameters in a healthy myopic population using optical coherence tomography angiography (angio-OCT).Patients and Methods: Three hundred and eighty-one eyes of 381 healthy participants were included into this study and assigned to three groups according to their spherical equivalent (SE) values and an additional progressive myopia group. One randomly chosen eye from each patient was analyzed. GCC mean thickness, focal loss of volume (FLV), global loss of volume (GLV), FAZ area, FAZ perimeter, and FD parameters were obtained with the RTVue AngioOCT device.Results: FAZ area and its perimeter were strongly correlated with the belonging spherical equivalent group (p = 0.0001, p = 0.0008 accordingly), being the largest in progressive myopia subgroup (mean size 0.42mm2). Other factors that were significantly higher in myopic eyes were FLV (p = 0.0023), GLV (p = 0.0020). There were no differences in FD between groups. In the myopic and progressive myopia groups, there was a significant relationship between FAZ area and FLV, GLV, and GCC thickness. We found that in myopic eyes with AXL exceeding 26.6 mm, FAZ becomes negatively correlated to mean GCC thickness.Conclusion: In myopia, compared to non-myopic groups, there is a greater loss of neural tissue represented by a thinner GCC layer, greater FLV and GLV parameters, and worse blood supply represented by a larger FAZ area. Eye axial length of 26.6 mm is a breaking point, where the negative FAZ area to GCC thickness relationship curve is getting significantly steeper.Keywords: GCC, FAZ, optical coherence tomography angiography, OCTAhttps://www.dovepress.com/macular-vascularity-and-ganglion-cell-complex-parameters-in-the-young--peer-reviewed-fulltext-article-OPTHgccfazoptical coherence tomography angiographyocta |
| spellingShingle | Małyszczak A Żyto M Przeździecka-Dołyk J Misiuk-Hojło M Macular Vascularity and Ganglion Cell Complex Parameters in the Young Adults with Myopia and Progressive Myopia Clinical Ophthalmology gcc faz optical coherence tomography angiography octa |
| title | Macular Vascularity and Ganglion Cell Complex Parameters in the Young Adults with Myopia and Progressive Myopia |
| title_full | Macular Vascularity and Ganglion Cell Complex Parameters in the Young Adults with Myopia and Progressive Myopia |
| title_fullStr | Macular Vascularity and Ganglion Cell Complex Parameters in the Young Adults with Myopia and Progressive Myopia |
| title_full_unstemmed | Macular Vascularity and Ganglion Cell Complex Parameters in the Young Adults with Myopia and Progressive Myopia |
| title_short | Macular Vascularity and Ganglion Cell Complex Parameters in the Young Adults with Myopia and Progressive Myopia |
| title_sort | macular vascularity and ganglion cell complex parameters in the young adults with myopia and progressive myopia |
| topic | gcc faz optical coherence tomography angiography octa |
| url | https://www.dovepress.com/macular-vascularity-and-ganglion-cell-complex-parameters-in-the-young--peer-reviewed-fulltext-article-OPTH |
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