Axonal Computations
Axons functionally link the somato-dendritic compartment to synaptic terminals. Structurally and functionally diverse, they accomplish a central role in determining the delays and reliability with which neuronal ensembles communicate. By combining their active and passive biophysical properties, the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00413/full |
| _version_ | 1818258917999771648 |
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| author | Pepe Alcami Pepe Alcami Ahmed El Hady Ahmed El Hady |
| author_facet | Pepe Alcami Pepe Alcami Ahmed El Hady Ahmed El Hady |
| author_sort | Pepe Alcami |
| collection | DOAJ |
| description | Axons functionally link the somato-dendritic compartment to synaptic terminals. Structurally and functionally diverse, they accomplish a central role in determining the delays and reliability with which neuronal ensembles communicate. By combining their active and passive biophysical properties, they ensure a plethora of physiological computations. In this review, we revisit the biophysics of generation and propagation of electrical signals in the axon and their dynamics. We further place the computational abilities of axons in the context of intracellular and intercellular coupling. We discuss how, by means of sophisticated biophysical mechanisms, axons expand the repertoire of axonal computation, and thereby, of neural computation. |
| first_indexed | 2024-12-12T18:07:10Z |
| format | Article |
| id | doaj.art-8d5824ad13a54e3f88191e460d17f8f5 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-12T18:07:10Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-8d5824ad13a54e3f88191e460d17f8f52022-12-22T00:16:27ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-09-011310.3389/fncel.2019.00413469994Axonal ComputationsPepe Alcami0Pepe Alcami1Ahmed El Hady2Ahmed El Hady3Division of Neurobiology, Department of Biology II, Ludwig-Maximilians-Universitaet Muenchen, Martinsried, GermanyDepartment of Behavioural Neurobiology, Max Planck Institute for Ornithology, Seewiesen, GermanyPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, United StatesHoward Hughes Medical Institute, Princeton University, Princeton, NJ, United StatesAxons functionally link the somato-dendritic compartment to synaptic terminals. Structurally and functionally diverse, they accomplish a central role in determining the delays and reliability with which neuronal ensembles communicate. By combining their active and passive biophysical properties, they ensure a plethora of physiological computations. In this review, we revisit the biophysics of generation and propagation of electrical signals in the axon and their dynamics. We further place the computational abilities of axons in the context of intracellular and intercellular coupling. We discuss how, by means of sophisticated biophysical mechanisms, axons expand the repertoire of axonal computation, and thereby, of neural computation.https://www.frontiersin.org/article/10.3389/fncel.2019.00413/fullanalog-digital signalingaction potential generationpropagationresistancecapacitancemyelin |
| spellingShingle | Pepe Alcami Pepe Alcami Ahmed El Hady Ahmed El Hady Axonal Computations Frontiers in Cellular Neuroscience analog-digital signaling action potential generation propagation resistance capacitance myelin |
| title | Axonal Computations |
| title_full | Axonal Computations |
| title_fullStr | Axonal Computations |
| title_full_unstemmed | Axonal Computations |
| title_short | Axonal Computations |
| title_sort | axonal computations |
| topic | analog-digital signaling action potential generation propagation resistance capacitance myelin |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00413/full |
| work_keys_str_mv | AT pepealcami axonalcomputations AT pepealcami axonalcomputations AT ahmedelhady axonalcomputations AT ahmedelhady axonalcomputations |