Heart Rate and Systolic Blood Pressure Variability in the Time Domain in Patients with Recent and Long-Standing Diabetes Mellitus.
Diabetes Mellitus (DM) affects the cardiovascular response of patients. To study this effect, interbeat intervals (IBI) and beat-to-beat systolic blood pressure (SBP) variability of patients during supine, standing and controlled breathing tests were analyzed in the time domain. Simultaneous noninva...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4746070?pdf=render |
| _version_ | 1818949449858154496 |
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| author | Ana Leonor Rivera Bruno Estañol Horacio Sentíes-Madrid Ruben Fossion Juan C Toledo-Roy Joel Mendoza-Temis Irving O Morales Emmanuel Landa Adriana Robles-Cabrera Rene Moreno Alejandro Frank |
| author_facet | Ana Leonor Rivera Bruno Estañol Horacio Sentíes-Madrid Ruben Fossion Juan C Toledo-Roy Joel Mendoza-Temis Irving O Morales Emmanuel Landa Adriana Robles-Cabrera Rene Moreno Alejandro Frank |
| author_sort | Ana Leonor Rivera |
| collection | DOAJ |
| description | Diabetes Mellitus (DM) affects the cardiovascular response of patients. To study this effect, interbeat intervals (IBI) and beat-to-beat systolic blood pressure (SBP) variability of patients during supine, standing and controlled breathing tests were analyzed in the time domain. Simultaneous noninvasive measurements of IBI and SBP for 30 recently diagnosed and 15 long-standing DM patients were compared with the results for 30 rigorously screened healthy subjects (control). A statistically significant distinction between control and diabetic subjects was provided by the standard deviation and the higher moments of the distributions (skewness, and kurtosis) with respect to the median. To compare IBI and SBP for different populations, we define a parameter, α, that combines the variability of the heart rate and the blood pressure, as the ratio of the radius of the moments for IBI and the same radius for SBP. As diabetes evolves, α decreases, standard deviation of the IBI detrended signal diminishes (heart rate signal becomes more "rigid"), skewness with respect to the median approaches zero (signal fluctuations gain symmetry), and kurtosis increases (fluctuations concentrate around the median). Diabetes produces not only a rigid heart rate, but also increases symmetry and has leptokurtic distributions. SBP time series exhibit the most variable behavior for recently diagnosed DM with platykurtic distributions. Under controlled breathing, SBP has symmetric distributions for DM patients, while control subjects have non-zero skewness. This may be due to a progressive decrease of parasympathetic and sympathetic activity to the heart and blood vessels as diabetes evolves. |
| first_indexed | 2024-12-20T09:02:53Z |
| format | Article |
| id | doaj.art-8d59cfdc1f8d446c922fbda2af6bf2a4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T09:02:53Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8d59cfdc1f8d446c922fbda2af6bf2a42022-12-21T19:45:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014837810.1371/journal.pone.0148378Heart Rate and Systolic Blood Pressure Variability in the Time Domain in Patients with Recent and Long-Standing Diabetes Mellitus.Ana Leonor RiveraBruno EstañolHoracio Sentíes-MadridRuben FossionJuan C Toledo-RoyJoel Mendoza-TemisIrving O MoralesEmmanuel LandaAdriana Robles-CabreraRene MorenoAlejandro FrankDiabetes Mellitus (DM) affects the cardiovascular response of patients. To study this effect, interbeat intervals (IBI) and beat-to-beat systolic blood pressure (SBP) variability of patients during supine, standing and controlled breathing tests were analyzed in the time domain. Simultaneous noninvasive measurements of IBI and SBP for 30 recently diagnosed and 15 long-standing DM patients were compared with the results for 30 rigorously screened healthy subjects (control). A statistically significant distinction between control and diabetic subjects was provided by the standard deviation and the higher moments of the distributions (skewness, and kurtosis) with respect to the median. To compare IBI and SBP for different populations, we define a parameter, α, that combines the variability of the heart rate and the blood pressure, as the ratio of the radius of the moments for IBI and the same radius for SBP. As diabetes evolves, α decreases, standard deviation of the IBI detrended signal diminishes (heart rate signal becomes more "rigid"), skewness with respect to the median approaches zero (signal fluctuations gain symmetry), and kurtosis increases (fluctuations concentrate around the median). Diabetes produces not only a rigid heart rate, but also increases symmetry and has leptokurtic distributions. SBP time series exhibit the most variable behavior for recently diagnosed DM with platykurtic distributions. Under controlled breathing, SBP has symmetric distributions for DM patients, while control subjects have non-zero skewness. This may be due to a progressive decrease of parasympathetic and sympathetic activity to the heart and blood vessels as diabetes evolves.http://europepmc.org/articles/PMC4746070?pdf=render |
| spellingShingle | Ana Leonor Rivera Bruno Estañol Horacio Sentíes-Madrid Ruben Fossion Juan C Toledo-Roy Joel Mendoza-Temis Irving O Morales Emmanuel Landa Adriana Robles-Cabrera Rene Moreno Alejandro Frank Heart Rate and Systolic Blood Pressure Variability in the Time Domain in Patients with Recent and Long-Standing Diabetes Mellitus. PLoS ONE |
| title | Heart Rate and Systolic Blood Pressure Variability in the Time Domain in Patients with Recent and Long-Standing Diabetes Mellitus. |
| title_full | Heart Rate and Systolic Blood Pressure Variability in the Time Domain in Patients with Recent and Long-Standing Diabetes Mellitus. |
| title_fullStr | Heart Rate and Systolic Blood Pressure Variability in the Time Domain in Patients with Recent and Long-Standing Diabetes Mellitus. |
| title_full_unstemmed | Heart Rate and Systolic Blood Pressure Variability in the Time Domain in Patients with Recent and Long-Standing Diabetes Mellitus. |
| title_short | Heart Rate and Systolic Blood Pressure Variability in the Time Domain in Patients with Recent and Long-Standing Diabetes Mellitus. |
| title_sort | heart rate and systolic blood pressure variability in the time domain in patients with recent and long standing diabetes mellitus |
| url | http://europepmc.org/articles/PMC4746070?pdf=render |
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