The Role of Inflammatory Markers in the Differential Diagnosis of Skin Cancers
Aim: The purpose of this study was to evaluate the role of WBC count, NLR, LMR, PLR, Systemic immune-inflammation index (SII) [(platelet count X neutrophil count) \ lymphocyte count] and platelet count (Plt)×NLR in the differential diagnosis of basal cell carcinoma, squamous cell carcinoma, and mali...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Rabia Yılmaz
2022-09-01
|
| Series: | Journal of Contemporary Medicine |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/2490435 |
| _version_ | 1797860765736108032 |
|---|---|
| author | Hande Demir Sanem Nemmezi Karaca Handan Derebaşınlıoğlu |
| author_facet | Hande Demir Sanem Nemmezi Karaca Handan Derebaşınlıoğlu |
| author_sort | Hande Demir |
| collection | DOAJ |
| description | Aim: The purpose of this study was to evaluate the role of WBC count, NLR, LMR, PLR, Systemic immune-inflammation index (SII) [(platelet count X neutrophil count) \ lymphocyte count] and platelet count (Plt)×NLR in the differential diagnosis of basal cell carcinoma, squamous cell carcinoma, and malignant melanoma and to determine the effect of tumor type, prediction of lymph node metastasis at initial diagnosis and location on these inflammatory markers.
Material and Method: Patients who underwent surgery for basal cell carcinoma, squamous cell carcinoma, or malignant melanoma were retrospectively screened. NLR, LMR, PLR, SII and Plt×NLR were calculated. Relationships between tumor type, prediction of lymph node metastasis at initial diagnosis, tumor localization and the inflammatory and hematological parameters of interest were investigated. Tumor location was classified as head and neck and others.
Results: A total of 257 patients were included in the study. No statistically significant differences in WBC, NLR, PLR, LMR, SII or Plt×NLR were detected according to tumor location. The patients with squamous cell carcinoma had higher NLR, PRL, SII and Plt×NLR values than those with basal cell carcinoma. The risk of lymph node metastasis at the time of initial diagnosis was 10.3 times higher in patients with PLR levels of 180.7 and higher. The risk of lymph node metastasis detected at initial diagnosis was 8.9 times higher in patients with Plt×NLR of 747 and higher. The risk of lymph node metastasis detected at initial diagnosis was 7.1 times higher in patients with SII of 414 and higher.
Conclusion: Inflammatory markers seem to be useful in the differential diagnosis of skin cancers and determined the risk of lymph node metastasis. However, it does not differ according to tumor localization. |
| first_indexed | 2024-04-09T21:50:52Z |
| format | Article |
| id | doaj.art-8d5a64616cf549c9a770c34b600aa826 |
| institution | Directory Open Access Journal |
| issn | 2667-7180 |
| language | English |
| last_indexed | 2024-04-09T21:50:52Z |
| publishDate | 2022-09-01 |
| publisher | Rabia Yılmaz |
| record_format | Article |
| series | Journal of Contemporary Medicine |
| spelling | doaj.art-8d5a64616cf549c9a770c34b600aa8262023-03-24T19:43:21ZengRabia YılmazJournal of Contemporary Medicine2667-71802022-09-0112576176910.16899/jcm.11317081809The Role of Inflammatory Markers in the Differential Diagnosis of Skin CancersHande Demir0Sanem Nemmezi Karaca1Handan Derebaşınlıoğlu2SİVAS CUMHURİYET ÜNİVERSİTESİSİVAS CUMHURİYET ÜNİVERSİTESİSİVAS CUMHURİYET ÜNİVERSİTESİAim: The purpose of this study was to evaluate the role of WBC count, NLR, LMR, PLR, Systemic immune-inflammation index (SII) [(platelet count X neutrophil count) \ lymphocyte count] and platelet count (Plt)×NLR in the differential diagnosis of basal cell carcinoma, squamous cell carcinoma, and malignant melanoma and to determine the effect of tumor type, prediction of lymph node metastasis at initial diagnosis and location on these inflammatory markers. Material and Method: Patients who underwent surgery for basal cell carcinoma, squamous cell carcinoma, or malignant melanoma were retrospectively screened. NLR, LMR, PLR, SII and Plt×NLR were calculated. Relationships between tumor type, prediction of lymph node metastasis at initial diagnosis, tumor localization and the inflammatory and hematological parameters of interest were investigated. Tumor location was classified as head and neck and others. Results: A total of 257 patients were included in the study. No statistically significant differences in WBC, NLR, PLR, LMR, SII or Plt×NLR were detected according to tumor location. The patients with squamous cell carcinoma had higher NLR, PRL, SII and Plt×NLR values than those with basal cell carcinoma. The risk of lymph node metastasis at the time of initial diagnosis was 10.3 times higher in patients with PLR levels of 180.7 and higher. The risk of lymph node metastasis detected at initial diagnosis was 8.9 times higher in patients with Plt×NLR of 747 and higher. The risk of lymph node metastasis detected at initial diagnosis was 7.1 times higher in patients with SII of 414 and higher. Conclusion: Inflammatory markers seem to be useful in the differential diagnosis of skin cancers and determined the risk of lymph node metastasis. However, it does not differ according to tumor localization.https://dergipark.org.tr/tr/download/article-file/2490435basal cell carcinomasquamous cell carcinomamalignant melanomaneutrophil to lymphocyte ratio (nlr)lymphocyte to monocyte ratio (lmr)systemic immune-inflammation index (sii)and platelet to lymphocyte ratio (plrbazal hücreli karsinomskuamöz hücreli karsinommalign melanomnötrofil-lenfosit oranı (nlr)lenfosit-monosit oranı (lmr)sistemik immün-enflamasyon indeksi (sii) trombosit/lenfosit oranı (plr)sistemik immün-enflamasyon indeksi (sii) trombosit/lenfosit oranı (plr) |
| spellingShingle | Hande Demir Sanem Nemmezi Karaca Handan Derebaşınlıoğlu The Role of Inflammatory Markers in the Differential Diagnosis of Skin Cancers Journal of Contemporary Medicine basal cell carcinoma squamous cell carcinoma malignant melanoma neutrophil to lymphocyte ratio (nlr) lymphocyte to monocyte ratio (lmr) systemic immune-inflammation index (sii) and platelet to lymphocyte ratio (plr bazal hücreli karsinom skuamöz hücreli karsinom malign melanom nötrofil-lenfosit oranı (nlr) lenfosit-monosit oranı (lmr) sistemik immün-enflamasyon indeksi (sii) trombosit/lenfosit oranı (plr) sistemik immün-enflamasyon indeksi (sii) trombosit/lenfosit oranı (plr) |
| title | The Role of Inflammatory Markers in the Differential Diagnosis of Skin Cancers |
| title_full | The Role of Inflammatory Markers in the Differential Diagnosis of Skin Cancers |
| title_fullStr | The Role of Inflammatory Markers in the Differential Diagnosis of Skin Cancers |
| title_full_unstemmed | The Role of Inflammatory Markers in the Differential Diagnosis of Skin Cancers |
| title_short | The Role of Inflammatory Markers in the Differential Diagnosis of Skin Cancers |
| title_sort | role of inflammatory markers in the differential diagnosis of skin cancers |
| topic | basal cell carcinoma squamous cell carcinoma malignant melanoma neutrophil to lymphocyte ratio (nlr) lymphocyte to monocyte ratio (lmr) systemic immune-inflammation index (sii) and platelet to lymphocyte ratio (plr bazal hücreli karsinom skuamöz hücreli karsinom malign melanom nötrofil-lenfosit oranı (nlr) lenfosit-monosit oranı (lmr) sistemik immün-enflamasyon indeksi (sii) trombosit/lenfosit oranı (plr) sistemik immün-enflamasyon indeksi (sii) trombosit/lenfosit oranı (plr) |
| url | https://dergipark.org.tr/tr/download/article-file/2490435 |
| work_keys_str_mv | AT handedemir theroleofinflammatorymarkersinthedifferentialdiagnosisofskincancers AT sanemnemmezikaraca theroleofinflammatorymarkersinthedifferentialdiagnosisofskincancers AT handanderebasınlıoglu theroleofinflammatorymarkersinthedifferentialdiagnosisofskincancers AT handedemir roleofinflammatorymarkersinthedifferentialdiagnosisofskincancers AT sanemnemmezikaraca roleofinflammatorymarkersinthedifferentialdiagnosisofskincancers AT handanderebasınlıoglu roleofinflammatorymarkersinthedifferentialdiagnosisofskincancers |