Association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
BackgroundImpaired cerebrovasoreactivity is thought to play an important role in the pathophysiology of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We aimed to clarify the association between cerebrovascular reactivity and stroke in patients...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1087220/full |
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| author | Mao Mukai Ai Hamano Ikuko Mizuta Isao Yokota Akiko Watanabe-Hosomi Hiraku Matsuura Takashi Koizumi Takashi Koizumi Jun Matsuura Tomoyuki Ohara Shigenori Matsushima Satoshi Teramukai Kei Yamada Toshiki Mizuno |
| author_facet | Mao Mukai Ai Hamano Ikuko Mizuta Isao Yokota Akiko Watanabe-Hosomi Hiraku Matsuura Takashi Koizumi Takashi Koizumi Jun Matsuura Tomoyuki Ohara Shigenori Matsushima Satoshi Teramukai Kei Yamada Toshiki Mizuno |
| author_sort | Mao Mukai |
| collection | DOAJ |
| description | BackgroundImpaired cerebrovasoreactivity is thought to play an important role in the pathophysiology of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We aimed to clarify the association between cerebrovascular reactivity and stroke in patients with CADASIL.MethodsWe retrospectively recruited 14 patients with CADASIL, eight of whom had symptomatic stroke. They underwent quantitative single-photon emission computed tomography using an autoradiographic method at rest and after acetazolamide (ACZ) administration. Regional cerebral blood flow (rCBF) in the cerebral cortex, lenticular nucleus, thalamus, and cerebellum was measured. We compared the rCBF parameters between patients with and without stroke.ResultsThe baseline characteristics and magnetic resonance imaging findings were similar between the two groups, except for a higher frequency of pyramidal tract sign (75% vs. 0%) and a larger number of old lacunes (15.4 ± 8.8 vs. 2.2 ± 1.8) in the patients with stroke. Of the rCBF parameters measured, significantly lower flow (mL/100 g/min) was observed in ACZ-rCBF in the thalamus (35.6 ± 9.4 vs. 51.1 ± 7.6, p = 0.01) and ΔrCBF in the thalamus (10.6 ± 3.7 vs. 21.0 ± 7.9, p = 0.02) in the patients with stroke.ConclusionCerebrovasoreactivity in the thalamus was significantly associated with stroke in patients with CADASIL. |
| first_indexed | 2024-04-11T00:07:47Z |
| format | Article |
| id | doaj.art-8d5c042e35784a6a86b53058552e7ae3 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T00:07:47Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-8d5c042e35784a6a86b53058552e7ae32023-01-09T09:10:25ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-01-011310.3389/fneur.2022.10872201087220Association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathyMao Mukai0Ai Hamano1Ikuko Mizuta2Isao Yokota3Akiko Watanabe-Hosomi4Hiraku Matsuura5Takashi Koizumi6Takashi Koizumi7Jun Matsuura8Tomoyuki Ohara9Shigenori Matsushima10Satoshi Teramukai11Kei Yamada12Toshiki Mizuno13Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Biostatistics, Graduate School of Medicine, Hokkaido University, Sapporo, JapanDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanBackgroundImpaired cerebrovasoreactivity is thought to play an important role in the pathophysiology of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We aimed to clarify the association between cerebrovascular reactivity and stroke in patients with CADASIL.MethodsWe retrospectively recruited 14 patients with CADASIL, eight of whom had symptomatic stroke. They underwent quantitative single-photon emission computed tomography using an autoradiographic method at rest and after acetazolamide (ACZ) administration. Regional cerebral blood flow (rCBF) in the cerebral cortex, lenticular nucleus, thalamus, and cerebellum was measured. We compared the rCBF parameters between patients with and without stroke.ResultsThe baseline characteristics and magnetic resonance imaging findings were similar between the two groups, except for a higher frequency of pyramidal tract sign (75% vs. 0%) and a larger number of old lacunes (15.4 ± 8.8 vs. 2.2 ± 1.8) in the patients with stroke. Of the rCBF parameters measured, significantly lower flow (mL/100 g/min) was observed in ACZ-rCBF in the thalamus (35.6 ± 9.4 vs. 51.1 ± 7.6, p = 0.01) and ΔrCBF in the thalamus (10.6 ± 3.7 vs. 21.0 ± 7.9, p = 0.02) in the patients with stroke.ConclusionCerebrovasoreactivity in the thalamus was significantly associated with stroke in patients with CADASIL.https://www.frontiersin.org/articles/10.3389/fneur.2022.1087220/fullcerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathystrokecerebrovasoreactivitysingle-photon emission computed tomographyacetazolamide |
| spellingShingle | Mao Mukai Ai Hamano Ikuko Mizuta Isao Yokota Akiko Watanabe-Hosomi Hiraku Matsuura Takashi Koizumi Takashi Koizumi Jun Matsuura Tomoyuki Ohara Shigenori Matsushima Satoshi Teramukai Kei Yamada Toshiki Mizuno Association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy Frontiers in Neurology cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy stroke cerebrovasoreactivity single-photon emission computed tomography acetazolamide |
| title | Association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |
| title_full | Association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |
| title_fullStr | Association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |
| title_full_unstemmed | Association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |
| title_short | Association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |
| title_sort | association between cerebrovasoreactivity and stroke in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |
| topic | cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy stroke cerebrovasoreactivity single-photon emission computed tomography acetazolamide |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1087220/full |
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