LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program

LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program

Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes transcription of UCP1 and other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as a direct binding partner of Zfp516. We show that, through interaction wit...

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Bibliographic Details
Main Authors: Audrey Sambeat, Olga Gulyaeva, Jon Dempersmier, Kevin M. Tharp, Andreas Stahl, Sarah M. Paul, Hei Sook Sul
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716305873

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