Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals develop severe metabolic complications including diabetes and hepatic steatosis. Bscl2-deficient mice almost entirely reproduce the CGL phenotype. Adipose tissue-specific...

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Bibliographic Details
Main Authors: George D. Mcilroy, Sharon E. Mitchell, Weiping Han, Mirela Delibegović, Justin J. Rochford
Format: Article
Language:English
Published: The Company of Biologists 2020-01-01
Series:Disease Models & Mechanisms
Subjects:
lipodystrophy
bscl2
cgl
hepatocyte
aav
crispr
Online Access:http://dmm.biologists.org/content/13/1/dmm042655

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