Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets
Induced proximity can be used to control diverse cellular processes. Here, the authors develop nanobody-based proximity inducers called SNACIPs, which can be used to regulate either tagged or endogenous proteins, and demonstrate their use in blocking microtubule nucleation for tumour growth inhibiti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37237-x |
| _version_ | 1797859896008376320 |
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| author | Xiaofeng Sun Chengjian Zhou Simin Xia Xi Chen |
| author_facet | Xiaofeng Sun Chengjian Zhou Simin Xia Xi Chen |
| author_sort | Xiaofeng Sun |
| collection | DOAJ |
| description | Induced proximity can be used to control diverse cellular processes. Here, the authors develop nanobody-based proximity inducers called SNACIPs, which can be used to regulate either tagged or endogenous proteins, and demonstrate their use in blocking microtubule nucleation for tumour growth inhibition in vivo. |
| first_indexed | 2024-04-09T21:36:59Z |
| format | Article |
| id | doaj.art-8d648054d0dc4a5083da010f24e1a7e1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T21:36:59Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8d648054d0dc4a5083da010f24e1a7e12023-03-26T11:13:54ZengNature PortfolioNature Communications2041-17232023-03-0114111610.1038/s41467-023-37237-xSmall molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targetsXiaofeng Sun0Chengjian Zhou1Simin Xia2Xi Chen3Laboratory of Chemical Biology & Frontier Biotechnologies, The HIT Center for Life Sciences (HCLS), Harbin Institute of Technology (HIT)Laboratory of Chemical Biology & Frontier Biotechnologies, The HIT Center for Life Sciences (HCLS), Harbin Institute of Technology (HIT)Laboratory of Chemical Biology & Frontier Biotechnologies, The HIT Center for Life Sciences (HCLS), Harbin Institute of Technology (HIT)Laboratory of Chemical Biology & Frontier Biotechnologies, The HIT Center for Life Sciences (HCLS), Harbin Institute of Technology (HIT)Induced proximity can be used to control diverse cellular processes. Here, the authors develop nanobody-based proximity inducers called SNACIPs, which can be used to regulate either tagged or endogenous proteins, and demonstrate their use in blocking microtubule nucleation for tumour growth inhibition in vivo.https://doi.org/10.1038/s41467-023-37237-x |
| spellingShingle | Xiaofeng Sun Chengjian Zhou Simin Xia Xi Chen Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets Nature Communications |
| title | Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets |
| title_full | Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets |
| title_fullStr | Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets |
| title_full_unstemmed | Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets |
| title_short | Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets |
| title_sort | small molecule nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets |
| url | https://doi.org/10.1038/s41467-023-37237-x |
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