Epidemiology and Risk Factors of Carbapenemase-Producing <em>Enterobacteriaceae</em> Acquisition and Colonization at a Korean Hospital over 1 Year
<b>Background</b>: Carbapenemase-producing <i>Enterobacteriaceae</i> (CPE) are known to be primarily responsible for the increasing spread of carbapenem-resistant <i>Enterobacteriaceae</i> and have therefore been targeted for preventing transmission and appropriat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/4/759 |
| _version_ | 1797606645161787392 |
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| author | Hye-Jin Kim Jung-Hee Hyun Hyo-Seon Jeong Yeon-Kyeng Lee |
| author_facet | Hye-Jin Kim Jung-Hee Hyun Hyo-Seon Jeong Yeon-Kyeng Lee |
| author_sort | Hye-Jin Kim |
| collection | DOAJ |
| description | <b>Background</b>: Carbapenemase-producing <i>Enterobacteriaceae</i> (CPE) are known to be primarily responsible for the increasing spread of carbapenem-resistant <i>Enterobacteriaceae</i> and have therefore been targeted for preventing transmission and appropriate treatment. This study aimed to describe the clinical and epidemiological characteristics and risk factors of CPE infection in terms of acquisition and colonization. <b>Methods</b>: We examined patients’ hospital data, including active screening on patients’ admission and in intensive care units (ICUs). We identified risk factors for CPE acquisition by comparing the clinical and epidemiological data of CPE-positive patients between colonization and acquisition groups. Results: A total of 77 CPE patients were included (51 colonized and 26 acquired). The most frequent <i>Enterobacteriaceae</i> species was <i>Klebsiella pneumoniae</i>. Among CPE-colonized patients, 80.4% had a hospitalization history within 3 months. CPE acquisition was significantly associated with treatment in an ICU [adjusted odds ratio (aOR): 46.72, 95% confidence interval (CI): 5.08–430.09] and holding a gastrointestinal tube (aOR: 12.70, 95% CI: 2.61–61.84). <b>Conclusions</b>: CPE acquisition was significantly associated with ICU stay, open wounds, holding catheters or tubes, and antibiotic treatment. Active CPE screening should be implemented on admission and periodically for high-risk patients. |
| first_indexed | 2024-03-11T05:18:08Z |
| format | Article |
| id | doaj.art-8d6486e0aa024ad99d64b280439a21a0 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T05:18:08Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-8d6486e0aa024ad99d64b280439a21a02023-11-17T18:03:37ZengMDPI AGAntibiotics2079-63822023-04-0112475910.3390/antibiotics12040759Epidemiology and Risk Factors of Carbapenemase-Producing <em>Enterobacteriaceae</em> Acquisition and Colonization at a Korean Hospital over 1 YearHye-Jin Kim0Jung-Hee Hyun1Hyo-Seon Jeong2Yeon-Kyeng Lee3Division of Healthcare Associated Infection Control, Bureau of Healthcare Safety and Immunization, Korea Disease Control and Prevention Agency (KDCA), Heungdeok-gu, Cheongju-si 28159, Republic of KoreaDivision of Healthcare Associated Infection Control, Bureau of Healthcare Safety and Immunization, Korea Disease Control and Prevention Agency (KDCA), Heungdeok-gu, Cheongju-si 28159, Republic of KoreaDivision of Healthcare Associated Infection Control, Bureau of Healthcare Safety and Immunization, Korea Disease Control and Prevention Agency (KDCA), Heungdeok-gu, Cheongju-si 28159, Republic of KoreaDivision of Healthcare Associated Infection Control, Bureau of Healthcare Safety and Immunization, Korea Disease Control and Prevention Agency (KDCA), Heungdeok-gu, Cheongju-si 28159, Republic of Korea<b>Background</b>: Carbapenemase-producing <i>Enterobacteriaceae</i> (CPE) are known to be primarily responsible for the increasing spread of carbapenem-resistant <i>Enterobacteriaceae</i> and have therefore been targeted for preventing transmission and appropriate treatment. This study aimed to describe the clinical and epidemiological characteristics and risk factors of CPE infection in terms of acquisition and colonization. <b>Methods</b>: We examined patients’ hospital data, including active screening on patients’ admission and in intensive care units (ICUs). We identified risk factors for CPE acquisition by comparing the clinical and epidemiological data of CPE-positive patients between colonization and acquisition groups. Results: A total of 77 CPE patients were included (51 colonized and 26 acquired). The most frequent <i>Enterobacteriaceae</i> species was <i>Klebsiella pneumoniae</i>. Among CPE-colonized patients, 80.4% had a hospitalization history within 3 months. CPE acquisition was significantly associated with treatment in an ICU [adjusted odds ratio (aOR): 46.72, 95% confidence interval (CI): 5.08–430.09] and holding a gastrointestinal tube (aOR: 12.70, 95% CI: 2.61–61.84). <b>Conclusions</b>: CPE acquisition was significantly associated with ICU stay, open wounds, holding catheters or tubes, and antibiotic treatment. Active CPE screening should be implemented on admission and periodically for high-risk patients.https://www.mdpi.com/2079-6382/12/4/759acquisitioncarbapenemase-producing <i>Enterobacteriaceae</i>colonizationrisk factors |
| spellingShingle | Hye-Jin Kim Jung-Hee Hyun Hyo-Seon Jeong Yeon-Kyeng Lee Epidemiology and Risk Factors of Carbapenemase-Producing <em>Enterobacteriaceae</em> Acquisition and Colonization at a Korean Hospital over 1 Year Antibiotics acquisition carbapenemase-producing <i>Enterobacteriaceae</i> colonization risk factors |
| title | Epidemiology and Risk Factors of Carbapenemase-Producing <em>Enterobacteriaceae</em> Acquisition and Colonization at a Korean Hospital over 1 Year |
| title_full | Epidemiology and Risk Factors of Carbapenemase-Producing <em>Enterobacteriaceae</em> Acquisition and Colonization at a Korean Hospital over 1 Year |
| title_fullStr | Epidemiology and Risk Factors of Carbapenemase-Producing <em>Enterobacteriaceae</em> Acquisition and Colonization at a Korean Hospital over 1 Year |
| title_full_unstemmed | Epidemiology and Risk Factors of Carbapenemase-Producing <em>Enterobacteriaceae</em> Acquisition and Colonization at a Korean Hospital over 1 Year |
| title_short | Epidemiology and Risk Factors of Carbapenemase-Producing <em>Enterobacteriaceae</em> Acquisition and Colonization at a Korean Hospital over 1 Year |
| title_sort | epidemiology and risk factors of carbapenemase producing em enterobacteriaceae em acquisition and colonization at a korean hospital over 1 year |
| topic | acquisition carbapenemase-producing <i>Enterobacteriaceae</i> colonization risk factors |
| url | https://www.mdpi.com/2079-6382/12/4/759 |
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