Preparation of new alkyne-modified ansamitocins by mutasynthesis

Preparation of new alkyne-modified ansamitocins by mutasynthesis

The preparation of alkyne-modified ansamitocins by mutasynthetic supplementation of Actinosynnema pretiosum mutants with alkyne-substituted aminobenzoic acids is described. This modification paved the way to introduce a thiol linker by Huisgen-type cycloaddition which can principally be utilized to...

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Bibliographic Details
Main Authors:	Kirsten Harmrolfs, Lena Mancuso, Binia Drung, Florenz Sasse, Andreas Kirschning
Format:	Article
Language:	English
Published:	Beilstein-Institut 2014-03-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	ansamitocins antibiotics antitumor agents click chemistry mutasynthesis natural products
Online Access:	https://doi.org/10.3762/bjoc.10.49

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