Blood microRNAs as potential diagnostic markers for hemorrhagic stroke
Proper medical treatment of a stroke victim relies on accurate and rapid differentiation between ischemic and hemorrhagic stroke, which in current practice is performed by computerized tomography (CT) or magnetic resonance imaging (MRI) scans. A panel of microRNAs could be an extremely useful clinic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=1;spage=13;epage=18;aulast=Martinez |
| _version_ | 1818190332615983104 |
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| author | Bridget Martinez Philip V Peplow |
| author_facet | Bridget Martinez Philip V Peplow |
| author_sort | Bridget Martinez |
| collection | DOAJ |
| description | Proper medical treatment of a stroke victim relies on accurate and rapid differentiation between ischemic and hemorrhagic stroke, which in current practice is performed by computerized tomography (CT) or magnetic resonance imaging (MRI) scans. A panel of microRNAs could be an extremely useful clinical tool for distinguishing between hemorrhagic and ischemic stroke. This review has shown that blood miRNA profile can distinguish hemorrhagic from ischemic stroke in patients and in experimental animal models. It also seems likely they can differentiate between intracerebral and subarachnoid hemorrhage stroke. The miRNA profile in cerebrospinal fluid could be a useful diagnostic tool for subarachnoid hemorrhagic stroke. Decreased or increased miRNA levels may be needed either as prevention or treatment of stroke. Administration in vivo of miR-130a inhibitor or miRNA mimic (miR-367, miR-223) in an intracerebral hemorrhage animal model improved neurological outcomes. |
| first_indexed | 2024-12-11T23:57:02Z |
| format | Article |
| id | doaj.art-8d64e69d42ae4a84a11a953c6bb22915 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-11T23:57:02Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-8d64e69d42ae4a84a11a953c6bb229152022-12-22T00:45:19ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-01121131810.4103/1673-5374.198965Blood microRNAs as potential diagnostic markers for hemorrhagic strokeBridget MartinezPhilip V PeplowProper medical treatment of a stroke victim relies on accurate and rapid differentiation between ischemic and hemorrhagic stroke, which in current practice is performed by computerized tomography (CT) or magnetic resonance imaging (MRI) scans. A panel of microRNAs could be an extremely useful clinical tool for distinguishing between hemorrhagic and ischemic stroke. This review has shown that blood miRNA profile can distinguish hemorrhagic from ischemic stroke in patients and in experimental animal models. It also seems likely they can differentiate between intracerebral and subarachnoid hemorrhage stroke. The miRNA profile in cerebrospinal fluid could be a useful diagnostic tool for subarachnoid hemorrhagic stroke. Decreased or increased miRNA levels may be needed either as prevention or treatment of stroke. Administration in vivo of miR-130a inhibitor or miRNA mimic (miR-367, miR-223) in an intracerebral hemorrhage animal model improved neurological outcomes.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=1;spage=13;epage=18;aulast=Martinezblood microRNAs; diagnostic biomarkers; hemorrhagic stroke; human patients; rat and mouse models |
| spellingShingle | Bridget Martinez Philip V Peplow Blood microRNAs as potential diagnostic markers for hemorrhagic stroke Neural Regeneration Research blood microRNAs; diagnostic biomarkers; hemorrhagic stroke; human patients; rat and mouse models |
| title | Blood microRNAs as potential diagnostic markers for hemorrhagic stroke |
| title_full | Blood microRNAs as potential diagnostic markers for hemorrhagic stroke |
| title_fullStr | Blood microRNAs as potential diagnostic markers for hemorrhagic stroke |
| title_full_unstemmed | Blood microRNAs as potential diagnostic markers for hemorrhagic stroke |
| title_short | Blood microRNAs as potential diagnostic markers for hemorrhagic stroke |
| title_sort | blood micrornas as potential diagnostic markers for hemorrhagic stroke |
| topic | blood microRNAs; diagnostic biomarkers; hemorrhagic stroke; human patients; rat and mouse models |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=1;spage=13;epage=18;aulast=Martinez |
| work_keys_str_mv | AT bridgetmartinez bloodmicrornasaspotentialdiagnosticmarkersforhemorrhagicstroke AT philipvpeplow bloodmicrornasaspotentialdiagnosticmarkersforhemorrhagicstroke |