Association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
PurposeTo investigate the associations between cytokine levels in the aqueous humor (AH) and hyperreflective foci (HF) on spectral-domain optical coherence tomography (SD-OCT) in neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV).MethodsThe prospective st...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.973025/full |
| _version_ | 1811209156538925056 |
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| author | Jianbo Mao Jianbo Mao Nuo Chen Shian Zhang Yuyan Fang Zicheng Zheng Sulan Wu Xin Ye Yijing Chen Yiqi Chen Yiqi Chen Lijun Shen Lijun Shen |
| author_facet | Jianbo Mao Jianbo Mao Nuo Chen Shian Zhang Yuyan Fang Zicheng Zheng Sulan Wu Xin Ye Yijing Chen Yiqi Chen Yiqi Chen Lijun Shen Lijun Shen |
| author_sort | Jianbo Mao |
| collection | DOAJ |
| description | PurposeTo investigate the associations between cytokine levels in the aqueous humor (AH) and hyperreflective foci (HF) on spectral-domain optical coherence tomography (SD-OCT) in neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV).MethodsThe prospective study included 63 eyes with nAMD, 44 with PCV, and 43 with cataracts (Controls). AH samples were obtained before anti-vascular endothelial growth factor (VEGF) therapy or cataract surgery. Cytokines interleukin 6 (IL-6), IL-8, IL-10, interferon-inducible protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), and VEGF were measured by multiplex bead assay. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and the number of HF were evaluated at baseline and 1 month after anti-VEGF treatment.ResultsNo significances difference in IL-6 and IL-8 levels were noted among the three groups (P = 0.370 and P = 0.067). VEGF, IP-10, and IL-10 levels were significantly higher in nAMD and PCV groups than in Controls (all P < 0.05). In nAMD, HF was positively correlated with VEGF (rs = 0.300, P = 0.025) and in eyes with HF group, VEGF and IL-10 were significantly higher than those without HF (P = 0.008 and P = 0.022). In PCV, no correlation was observed between HF and cytokines (all P > 0.05). After anti-VEGF treatment, patients with HF in nAMD and PCV were predisposed to worse visual outcomes (P = 0.022 and P = 0.015) and a significantly greater reduction in CMT (P = 0.001 and P = 0.057). And nAMD patients with HF were more sensitive to anti-VEGF treatment than those without HF (P = 0.029).ConclusionsIn the nAMD group, HF was positively correlated with VEGF. Patients in nAMD with HF had elevated levels of VEGF and IL-10 and responded favorably to anti-VEGF. HF might serve as an inflammatory biomarker and a predictive factor for therapeutic efficacy in patients with nAMD. |
| first_indexed | 2024-04-12T04:34:48Z |
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| id | doaj.art-8d669cffc0c74f718d3c2d8347689a7a |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-12T04:34:48Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-8d669cffc0c74f718d3c2d8347689a7a2022-12-22T03:47:50ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-09-01910.3389/fmed.2022.973025973025Association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathyJianbo Mao0Jianbo Mao1Nuo Chen2Shian Zhang3Yuyan Fang4Zicheng Zheng5Sulan Wu6Xin Ye7Yijing Chen8Yiqi Chen9Yiqi Chen10Lijun Shen11Lijun Shen12Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaCenter for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaHwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaCenter for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaCenter for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaPurposeTo investigate the associations between cytokine levels in the aqueous humor (AH) and hyperreflective foci (HF) on spectral-domain optical coherence tomography (SD-OCT) in neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV).MethodsThe prospective study included 63 eyes with nAMD, 44 with PCV, and 43 with cataracts (Controls). AH samples were obtained before anti-vascular endothelial growth factor (VEGF) therapy or cataract surgery. Cytokines interleukin 6 (IL-6), IL-8, IL-10, interferon-inducible protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), and VEGF were measured by multiplex bead assay. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and the number of HF were evaluated at baseline and 1 month after anti-VEGF treatment.ResultsNo significances difference in IL-6 and IL-8 levels were noted among the three groups (P = 0.370 and P = 0.067). VEGF, IP-10, and IL-10 levels were significantly higher in nAMD and PCV groups than in Controls (all P < 0.05). In nAMD, HF was positively correlated with VEGF (rs = 0.300, P = 0.025) and in eyes with HF group, VEGF and IL-10 were significantly higher than those without HF (P = 0.008 and P = 0.022). In PCV, no correlation was observed between HF and cytokines (all P > 0.05). After anti-VEGF treatment, patients with HF in nAMD and PCV were predisposed to worse visual outcomes (P = 0.022 and P = 0.015) and a significantly greater reduction in CMT (P = 0.001 and P = 0.057). And nAMD patients with HF were more sensitive to anti-VEGF treatment than those without HF (P = 0.029).ConclusionsIn the nAMD group, HF was positively correlated with VEGF. Patients in nAMD with HF had elevated levels of VEGF and IL-10 and responded favorably to anti-VEGF. HF might serve as an inflammatory biomarker and a predictive factor for therapeutic efficacy in patients with nAMD.https://www.frontiersin.org/articles/10.3389/fmed.2022.973025/fullaqueous humorcytokinehyperreflective focineovascular age-related macular degenerationpolypoidal choroidal vasculopathyspectral-domain optical coherence tomography |
| spellingShingle | Jianbo Mao Jianbo Mao Nuo Chen Shian Zhang Yuyan Fang Zicheng Zheng Sulan Wu Xin Ye Yijing Chen Yiqi Chen Yiqi Chen Lijun Shen Lijun Shen Association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy Frontiers in Medicine aqueous humor cytokine hyperreflective foci neovascular age-related macular degeneration polypoidal choroidal vasculopathy spectral-domain optical coherence tomography |
| title | Association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
| title_full | Association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
| title_fullStr | Association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
| title_full_unstemmed | Association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
| title_short | Association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
| title_sort | association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age related macular degeneration and polypoidal choroidal vasculopathy |
| topic | aqueous humor cytokine hyperreflective foci neovascular age-related macular degeneration polypoidal choroidal vasculopathy spectral-domain optical coherence tomography |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.973025/full |
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