Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications
Purpose Although elective surgery is generally safe, some procedures remain associated with an increased risk of complications. Improved preoperative risk stratification and earlier recognition of these complications may ameliorate postoperative recovery and improve long-term outcomes. The periopera...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-04-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/4/e068970.full |
| _version_ | 1826986321128718336 |
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| author | Johannes B Reitsma Marc J M Bonten Anne Marie G A de Smet Remco de Bree Arjen J C Slooter Gert-Jan de Borst Imo E Hoefer Menno R Vriens Jelle P Ruurda Peter Noordzij Lisette M Vernooij Ronald P Zweemer Nikki de Mul Diede Verlaan Wilhelmina M U van Grevenstein Jeroen Hagendoorn Charles Vogely Jelle L G Haitsma Mulier Marcel R de Zoete Janetta Top Jan A J Kluijtmans Thijs Rettig Marije Marsman Lennie Derde Judith van Waes Mienke Rijsdijk Willem Jan M Schellekens Olaf L Cremer |
| author_facet | Johannes B Reitsma Marc J M Bonten Anne Marie G A de Smet Remco de Bree Arjen J C Slooter Gert-Jan de Borst Imo E Hoefer Menno R Vriens Jelle P Ruurda Peter Noordzij Lisette M Vernooij Ronald P Zweemer Nikki de Mul Diede Verlaan Wilhelmina M U van Grevenstein Jeroen Hagendoorn Charles Vogely Jelle L G Haitsma Mulier Marcel R de Zoete Janetta Top Jan A J Kluijtmans Thijs Rettig Marije Marsman Lennie Derde Judith van Waes Mienke Rijsdijk Willem Jan M Schellekens Olaf L Cremer |
| author_sort | Johannes B Reitsma |
| collection | DOAJ |
| description | Purpose Although elective surgery is generally safe, some procedures remain associated with an increased risk of complications. Improved preoperative risk stratification and earlier recognition of these complications may ameliorate postoperative recovery and improve long-term outcomes. The perioperative longitudinal study of complications and long-term outcomes (PLUTO) cohort aims to establish a comprehensive biorepository that will facilitate research in this field. In this profile paper, we will discuss its design rationale and opportunities for future studies.Participants Patients undergoing elective intermediate to high-risk non-cardiac surgery are eligible for enrolment. For the first seven postoperative days, participants are subjected to daily bedside visits by dedicated observers, who adjudicate clinical events and perform non-invasive physiological measurements (including handheld spirometry and single-channel electroencephalography). Blood samples and microbiome specimens are collected at preselected time points. Primary study outcomes are the postoperative occurrence of nosocomial infections, major adverse cardiac events, pulmonary complications, acute kidney injury and delirium/acute encephalopathy. Secondary outcomes include mortality and quality of life, as well as the long-term occurrence of psychopathology, cognitive dysfunction and chronic pain.Findings to date Enrolment of the first participant occurred early 2020. During the inception phase of the project (first 2 years), 431 patients were eligible of whom 297 patients consented to participate (69%). Observed event rate was 42% overall, with the most frequent complication being infection.Future plans The main purpose of the PLUTO biorepository is to provide a framework for research in the field of perioperative medicine and anaesthesiology, by storing high-quality clinical data and biomaterials for future studies. In addition, PLUTO aims to establish a logistical platform for conducting embedded clinical trials.Trial registration number NCT05331118. |
| first_indexed | 2024-03-12T21:04:07Z |
| format | Article |
| id | doaj.art-8d68fc10c3e94d30b4d1e3e6deaf8592 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2025-02-18T07:21:52Z |
| publishDate | 2023-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-8d68fc10c3e94d30b4d1e3e6deaf85922024-11-07T09:45:08ZengBMJ Publishing GroupBMJ Open2044-60552023-04-0113410.1136/bmjopen-2022-068970Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complicationsJohannes B Reitsma0Marc J M Bonten1Anne Marie G A de Smet2Remco de Bree3Arjen J C Slooter4Gert-Jan de Borst5Imo E Hoefer6Menno R Vriens7Jelle P Ruurda8Peter Noordzij9Lisette M Vernooij10Ronald P Zweemer11Nikki de Mul12Diede Verlaan13Wilhelmina M U van Grevenstein14Jeroen Hagendoorn15Charles Vogely16Jelle L G Haitsma Mulier17Marcel R de Zoete18Janetta Top19Jan A J Kluijtmans20Thijs Rettig21Marije Marsman22Lennie Derde23Judith van Waes24Mienke Rijsdijk25Willem Jan M Schellekens26Olaf L Cremer27Cochrane Netherlands, Julius Center for Health Sciences and Primary Care, Utrecht University, University Medical Center Utrecht, Utrecht, NetherlandsJulius Center, Department of Epidemiology, Program of Infectious Diseases, UMC Utrecht, Utrecht, The NetherlandsDepartment of Intensive Care Medicine, UMC Utrecht, Utrecht, The NetherlandsDepartment of Head and Neck Surgical Oncology, UMC Utrecht, Utrecht, The NetherlandsBrain Center, University Medical Centre, Utrecht, The NetherlandsDepartment of Vascular Surgery, UMC Utrecht, Utrecht, The NetherlandsCentral Diagnostic Laboratory, Universitair Medisch Centrum, Utrecht, The NetherlandsDepartment of Endocrine and Surgical Oncology, Cancer Center, UMC Utrecht, Utrecht, The NetherlandsDepartment of Surgical Oncology, Upper Gastro-Intestinal Surgery, UMC Utrecht, Utrecht, The NetherlandsDepartment of Anaesthesiology and Intensive Care, Antonius Ziekenhuis Nieuwegein, Nieuwegein, The Netherlands1 Department of Anaesthesiology, Intensive Care and Pain management, St. Antonius Hospital, Nieuwegein, NetherlandsDepartment of Gynaecological Oncology, UMC Utrecht, Utrecht, The NetherlandsDepartment of Anaesthesiology, UMC Utrecht, Utrecht, The NetherlandsDepartment of Intensive Care Medicine, UMC Utrecht, Utrecht, The NetherlandsDepartment of Surgical Oncology, General Surgery, UMC Utrecht, Utrecht, The NetherlandsDepartment of Surgical Oncology, Hepatobilliary and Pancreatic Surgery, UMC Utrecht, Utrecht, The NetherlandsDepartment of Orthopaedic Surgery, UMC Utrecht, Utrecht, The NetherlandsDepartment of Intensive Care Medicine, UMC Utrecht, Utrecht, The NetherlandsDepartment of Medical Microbiology, UMC Utrecht, Utrecht, The NetherlandsDepartment of Medical Microbiology, UMC Utrecht, Utrecht, The NetherlandsDepartment of Medical Microbiology, UMC Utrecht, Utrecht, The NetherlandsDepartment of Anesthesiology, Intensive Care and Pain Medicine, Amphia Hospital site Molengracht, Breda, The NetherlandsDepartment of Anaesthesiology, UMC Utrecht, Utrecht, The NetherlandsDepartment of Intensive Care Medicine, UMC Utrecht, Utrecht, The NetherlandsDepartment of Anaesthesiology, UMC Utrecht, Utrecht, The NetherlandsDepartment of Anaesthesiology, UMC Utrecht, Utrecht, The NetherlandsDepartment of Anaesthesiology, UMC Utrecht, Utrecht, The Netherlands6 Department of Intensive Care Medicine, University Medical Centre Utrecht, Utrecht, NetherlandsPurpose Although elective surgery is generally safe, some procedures remain associated with an increased risk of complications. Improved preoperative risk stratification and earlier recognition of these complications may ameliorate postoperative recovery and improve long-term outcomes. The perioperative longitudinal study of complications and long-term outcomes (PLUTO) cohort aims to establish a comprehensive biorepository that will facilitate research in this field. In this profile paper, we will discuss its design rationale and opportunities for future studies.Participants Patients undergoing elective intermediate to high-risk non-cardiac surgery are eligible for enrolment. For the first seven postoperative days, participants are subjected to daily bedside visits by dedicated observers, who adjudicate clinical events and perform non-invasive physiological measurements (including handheld spirometry and single-channel electroencephalography). Blood samples and microbiome specimens are collected at preselected time points. Primary study outcomes are the postoperative occurrence of nosocomial infections, major adverse cardiac events, pulmonary complications, acute kidney injury and delirium/acute encephalopathy. Secondary outcomes include mortality and quality of life, as well as the long-term occurrence of psychopathology, cognitive dysfunction and chronic pain.Findings to date Enrolment of the first participant occurred early 2020. During the inception phase of the project (first 2 years), 431 patients were eligible of whom 297 patients consented to participate (69%). Observed event rate was 42% overall, with the most frequent complication being infection.Future plans The main purpose of the PLUTO biorepository is to provide a framework for research in the field of perioperative medicine and anaesthesiology, by storing high-quality clinical data and biomaterials for future studies. In addition, PLUTO aims to establish a logistical platform for conducting embedded clinical trials.Trial registration number NCT05331118.https://bmjopen.bmj.com/content/13/4/e068970.full |
| spellingShingle | Johannes B Reitsma Marc J M Bonten Anne Marie G A de Smet Remco de Bree Arjen J C Slooter Gert-Jan de Borst Imo E Hoefer Menno R Vriens Jelle P Ruurda Peter Noordzij Lisette M Vernooij Ronald P Zweemer Nikki de Mul Diede Verlaan Wilhelmina M U van Grevenstein Jeroen Hagendoorn Charles Vogely Jelle L G Haitsma Mulier Marcel R de Zoete Janetta Top Jan A J Kluijtmans Thijs Rettig Marije Marsman Lennie Derde Judith van Waes Mienke Rijsdijk Willem Jan M Schellekens Olaf L Cremer Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications BMJ Open |
| title | Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
| title_full | Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
| title_fullStr | Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
| title_full_unstemmed | Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
| title_short | Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
| title_sort | cohort profile of pluto a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
| url | https://bmjopen.bmj.com/content/13/4/e068970.full |
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