NMR-Verified Dearomatization of 5,7-Substituted Pyrazolo[1,5-a]pyrimidines

NMR-Verified Dearomatization of 5,7-Substituted Pyrazolo[1,5-a]pyrimidines

Tetrahydropyrazolo[1,5-a]pyrimidine (THPP) is an attractive scaffold for designing biologically active compounds. The most obvious way to obtain such compounds is to reduce pyrazolopyrimidines with complex hydrides, because the pyrimidine ring is reduced in the preference over the pyrazole ring. The...

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Bibliographic Details
Main Authors: Daria Novikova, Ammar Al Mustafa, Tatyana Grigoreva, Svetlana Vorona, Stanislav Selivanov, Vyacheslav Tribulovich
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Molecules
Subjects:
pyrazolo[1,5-a]pyrimidine
dearomatization
NOESY
proton–proton vicinal constants
conformational analysis
long-range interproton distance
Online Access:https://www.mdpi.com/1420-3049/28/18/6584

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https://www.mdpi.com/1420-3049/28/18/6584

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