APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice

APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice

Abstract The most significant genetic risk factor for developing late-onset Alzheimer’s disease (AD) is the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key modulators of microglial and astroglial function, which exert multiple effects on AD pathogenesis. Here, we show...

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Bibliographic Details
Main Authors: T. L. Stephen, B. Breningstall, S. Suresh, C. J. McGill, C. J. Pike
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Apolipoprotein E
Astrocytes
Glial interactions
Sex
Online Access:https://doi.org/10.1186/s12974-022-02650-4

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