Association Between Statin Use and Prognosis of Breast Cancer: A Meta-Analysis of Cohort Studies
Background: Statin, a lipid-lowering drug, has been suggested to confer anticancer efficacy. However, previous studies evaluating the association between statin use and prognosis in breast cancer showed inconsistent results. A meta-analysis was performed to evaluate the association between statin us...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.556243/full |
| _version_ | 1818382280444346368 |
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| author | Hui Lv Ding Shi Min Fei Yu Chen Fei Xie Zhuoyan Wang Ying Wang Peiying Hu |
| author_facet | Hui Lv Ding Shi Min Fei Yu Chen Fei Xie Zhuoyan Wang Ying Wang Peiying Hu |
| author_sort | Hui Lv |
| collection | DOAJ |
| description | Background: Statin, a lipid-lowering drug, has been suggested to confer anticancer efficacy. However, previous studies evaluating the association between statin use and prognosis in breast cancer showed inconsistent results. A meta-analysis was performed to evaluate the association between statin use and clinical outcome in women with breast cancer.Methods: Cohort studies comparing recurrence or disease-specific mortality in women with breast cancer with and without using of statins were identified by search of PubMed, Embase, and Cochrane's Library databases. A random-effect model, incorporating the inter-study heterogeneity, was used to combine the results. Subgroup analyses were performed to evaluate the influences of study characteristics on the outcomesResults: Seventeen cohort studies with 168,700 women with breast cancer were included. Pooled results showed that statin use was significantly associated with a lower risk of breast cancer recurrence (adjusted hazard ratio [HR] = 0.72, p < 0.001) and breast cancer mortality (HR = 0.80, p < 0.001). Subgroup analysis showed that timing of statin use, statin type, study design, sample size, or quality score did not significantly affect the outcomes. However, statin use was associated with more remarkably reduced breast cancer recurrence in studies with mean follow-up duration ≤ 5 years (HR = 0.55, p < 0.001) than that in studies of >5 years (HR = 0.83, p = 0.01).Conclusions: Statin use is associated with reduced recurrence and disease-specific mortality in women with breast cancer. These results should be validated in randomized controlled trials. |
| first_indexed | 2024-12-14T02:47:58Z |
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| id | doaj.art-8d725e3d3d6c40a995fb6e9d6710bd26 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T02:47:58Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8d725e3d3d6c40a995fb6e9d6710bd262022-12-21T23:19:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.556243556243Association Between Statin Use and Prognosis of Breast Cancer: A Meta-Analysis of Cohort StudiesHui Lv0Ding Shi1Min Fei2Yu Chen3Fei Xie4Zhuoyan Wang5Ying Wang6Peiying Hu7Health Promotion Center, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaHealth Promotion Center, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaHealth Promotion Center, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaHealth Promotion Center, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaHealth Promotion Center, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaHealth Promotion Center, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaHealth Promotion Center, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, ChinaBackground: Statin, a lipid-lowering drug, has been suggested to confer anticancer efficacy. However, previous studies evaluating the association between statin use and prognosis in breast cancer showed inconsistent results. A meta-analysis was performed to evaluate the association between statin use and clinical outcome in women with breast cancer.Methods: Cohort studies comparing recurrence or disease-specific mortality in women with breast cancer with and without using of statins were identified by search of PubMed, Embase, and Cochrane's Library databases. A random-effect model, incorporating the inter-study heterogeneity, was used to combine the results. Subgroup analyses were performed to evaluate the influences of study characteristics on the outcomesResults: Seventeen cohort studies with 168,700 women with breast cancer were included. Pooled results showed that statin use was significantly associated with a lower risk of breast cancer recurrence (adjusted hazard ratio [HR] = 0.72, p < 0.001) and breast cancer mortality (HR = 0.80, p < 0.001). Subgroup analysis showed that timing of statin use, statin type, study design, sample size, or quality score did not significantly affect the outcomes. However, statin use was associated with more remarkably reduced breast cancer recurrence in studies with mean follow-up duration ≤ 5 years (HR = 0.55, p < 0.001) than that in studies of >5 years (HR = 0.83, p = 0.01).Conclusions: Statin use is associated with reduced recurrence and disease-specific mortality in women with breast cancer. These results should be validated in randomized controlled trials.https://www.frontiersin.org/article/10.3389/fonc.2020.556243/fullbreast cancerstatinrecurrencemortalitymeta-analysis |
| spellingShingle | Hui Lv Ding Shi Min Fei Yu Chen Fei Xie Zhuoyan Wang Ying Wang Peiying Hu Association Between Statin Use and Prognosis of Breast Cancer: A Meta-Analysis of Cohort Studies Frontiers in Oncology breast cancer statin recurrence mortality meta-analysis |
| title | Association Between Statin Use and Prognosis of Breast Cancer: A Meta-Analysis of Cohort Studies |
| title_full | Association Between Statin Use and Prognosis of Breast Cancer: A Meta-Analysis of Cohort Studies |
| title_fullStr | Association Between Statin Use and Prognosis of Breast Cancer: A Meta-Analysis of Cohort Studies |
| title_full_unstemmed | Association Between Statin Use and Prognosis of Breast Cancer: A Meta-Analysis of Cohort Studies |
| title_short | Association Between Statin Use and Prognosis of Breast Cancer: A Meta-Analysis of Cohort Studies |
| title_sort | association between statin use and prognosis of breast cancer a meta analysis of cohort studies |
| topic | breast cancer statin recurrence mortality meta-analysis |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.556243/full |
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