Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidence
Abstract Non-alcoholic fatty liver disease (NAFLD) as a chronic disease especially in Western countries, is still a tough question in the clinical therapy. With the rising prevalence of various chronic diseases, liver transplantation is expected to be the most common therapy after the next 10 years....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01292-0 |
| _version_ | 1797355658196025344 |
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| author | Jiali Zhang Baochen Ma Zixu Wang Yaoxing Chen Chengzhong Li Yulan Dong |
| author_facet | Jiali Zhang Baochen Ma Zixu Wang Yaoxing Chen Chengzhong Li Yulan Dong |
| author_sort | Jiali Zhang |
| collection | DOAJ |
| description | Abstract Non-alcoholic fatty liver disease (NAFLD) as a chronic disease especially in Western countries, is still a tough question in the clinical therapy. With the rising prevalence of various chronic diseases, liver transplantation is expected to be the most common therapy after the next 10 years. However, there is still no approved drug for NAFLD, and targeted therapy for NAFLD is urgent. Exosomes as a kind of extracellular vesicle are cell-derived nanovesicles, which play an essential role in intercellular communication. Due to complex cell–cell interactions in the liver, exosomes as therapeutic drugs or drug delivery vesicles may be involved in physiological or pathological processes in NAFLD. Compared with other nanomaterials, exosomes as a cell-free therapy, are not dependent on cell number limitation, which means can be administered safely in high doses. Apart from this, exosomes with the advantages of being low-toxic, high stability, and low-immunological are chosen for targeted therapy for many diseases. In this review, firstly we introduced the extracellular vesicles, including the biogenesis, composition, isolation and characterization, and fundamental function of extracellular vesicles. And then we discussed the modification of extracellular vesicles, cargo packing, and artificial exosomes. Finally, the extracellular vesicles for the therapies of NAFLD are summarized. Moreover, we highlight therapeutic approaches using exosomes in the clinical treatment of NAFLD, which provide valuable insights into targeting NAFLD in the clinical setting. Graphical Abstract Video Abstract |
| first_indexed | 2024-03-08T14:14:18Z |
| format | Article |
| id | doaj.art-8d749975ba544a81976e6537258e031b |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-08T14:14:18Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-8d749975ba544a81976e6537258e031b2024-01-14T12:30:28ZengBMCCell Communication and Signaling1478-811X2024-01-0122111510.1186/s12964-023-01292-0Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidenceJiali Zhang0Baochen Ma1Zixu Wang2Yaoxing Chen3Chengzhong Li4Yulan Dong5National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural UniversityChina Animal Husbandry GroupNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural UniversityNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural UniversityDepartment of Horticulture and Landscape Architecture, Jiangsu Agri-Animal Husbandry Vocational CollegeNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural UniversityAbstract Non-alcoholic fatty liver disease (NAFLD) as a chronic disease especially in Western countries, is still a tough question in the clinical therapy. With the rising prevalence of various chronic diseases, liver transplantation is expected to be the most common therapy after the next 10 years. However, there is still no approved drug for NAFLD, and targeted therapy for NAFLD is urgent. Exosomes as a kind of extracellular vesicle are cell-derived nanovesicles, which play an essential role in intercellular communication. Due to complex cell–cell interactions in the liver, exosomes as therapeutic drugs or drug delivery vesicles may be involved in physiological or pathological processes in NAFLD. Compared with other nanomaterials, exosomes as a cell-free therapy, are not dependent on cell number limitation, which means can be administered safely in high doses. Apart from this, exosomes with the advantages of being low-toxic, high stability, and low-immunological are chosen for targeted therapy for many diseases. In this review, firstly we introduced the extracellular vesicles, including the biogenesis, composition, isolation and characterization, and fundamental function of extracellular vesicles. And then we discussed the modification of extracellular vesicles, cargo packing, and artificial exosomes. Finally, the extracellular vesicles for the therapies of NAFLD are summarized. Moreover, we highlight therapeutic approaches using exosomes in the clinical treatment of NAFLD, which provide valuable insights into targeting NAFLD in the clinical setting. Graphical Abstract Video Abstracthttps://doi.org/10.1186/s12964-023-01292-0NAFLDExosomesExtracellular vesiclesNanomaterialsTherapy |
| spellingShingle | Jiali Zhang Baochen Ma Zixu Wang Yaoxing Chen Chengzhong Li Yulan Dong Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidence Cell Communication and Signaling NAFLD Exosomes Extracellular vesicles Nanomaterials Therapy |
| title | Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidence |
| title_full | Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidence |
| title_fullStr | Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidence |
| title_full_unstemmed | Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidence |
| title_short | Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidence |
| title_sort | extracellular vesicle therapy for obesity induced nafld a comprehensive review of current evidence |
| topic | NAFLD Exosomes Extracellular vesicles Nanomaterials Therapy |
| url | https://doi.org/10.1186/s12964-023-01292-0 |
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