Sirtuins—The New Important Players in Women’s Gynecological Health
The participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma has been indicated as of primary importance. Des...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/1/84 |
| _version_ | 1797413721277988864 |
|---|---|
| author | Ewa Maria Kratz Izabela Kokot Violetta Dymicka-Piekarska Agnieszka Piwowar |
| author_facet | Ewa Maria Kratz Izabela Kokot Violetta Dymicka-Piekarska Agnieszka Piwowar |
| author_sort | Ewa Maria Kratz |
| collection | DOAJ |
| description | The participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma has been indicated as of primary importance. Despite many existing studies, research on sirtuins continues to present an opportunity to discover new functions and dependencies, especially when it comes to women’s gynecological health. Sirtuins have a significant role in both the formation and the course of many gynecological diseases. Their role is particularly important and well documented in the course of the development of cancer within the female reproductive organs; however, disturbances observed in the ovary and oocyte as well as in follicular fluid are also widely investigated. Additionally, sirtuins take part in some gynecological disturbances as regulative factors in pathways associated with insulin resistance, glucose and lipids metabolism disorders. In this review, we would like to summarize the existing knowledge about sirtuins in the manner outlined above. |
| first_indexed | 2024-03-09T05:22:18Z |
| format | Article |
| id | doaj.art-8d7552de71df43a58491ca55f1913b89 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T05:22:18Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-8d7552de71df43a58491ca55f1913b892023-12-03T12:39:24ZengMDPI AGAntioxidants2076-39212021-01-011018410.3390/antiox10010084Sirtuins—The New Important Players in Women’s Gynecological HealthEwa Maria Kratz0Izabela Kokot1Violetta Dymicka-Piekarska2Agnieszka Piwowar3Department of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, PolandDepartment of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, PolandDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona Street 15A, 15-269 Bialystok, PolandDepartment of Toxicology, Faculty of Pharmacy, Wroclaw Medical University, Borowska Street 211, 50-556 Wroclaw, PolandThe participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma has been indicated as of primary importance. Despite many existing studies, research on sirtuins continues to present an opportunity to discover new functions and dependencies, especially when it comes to women’s gynecological health. Sirtuins have a significant role in both the formation and the course of many gynecological diseases. Their role is particularly important and well documented in the course of the development of cancer within the female reproductive organs; however, disturbances observed in the ovary and oocyte as well as in follicular fluid are also widely investigated. Additionally, sirtuins take part in some gynecological disturbances as regulative factors in pathways associated with insulin resistance, glucose and lipids metabolism disorders. In this review, we would like to summarize the existing knowledge about sirtuins in the manner outlined above.https://www.mdpi.com/2076-3921/10/1/84sirtuinswomen’s gynecological healthmarkers of gynecological diseasesoxidative stress |
| spellingShingle | Ewa Maria Kratz Izabela Kokot Violetta Dymicka-Piekarska Agnieszka Piwowar Sirtuins—The New Important Players in Women’s Gynecological Health Antioxidants sirtuins women’s gynecological health markers of gynecological diseases oxidative stress |
| title | Sirtuins—The New Important Players in Women’s Gynecological Health |
| title_full | Sirtuins—The New Important Players in Women’s Gynecological Health |
| title_fullStr | Sirtuins—The New Important Players in Women’s Gynecological Health |
| title_full_unstemmed | Sirtuins—The New Important Players in Women’s Gynecological Health |
| title_short | Sirtuins—The New Important Players in Women’s Gynecological Health |
| title_sort | sirtuins the new important players in women s gynecological health |
| topic | sirtuins women’s gynecological health markers of gynecological diseases oxidative stress |
| url | https://www.mdpi.com/2076-3921/10/1/84 |
| work_keys_str_mv | AT ewamariakratz sirtuinsthenewimportantplayersinwomensgynecologicalhealth AT izabelakokot sirtuinsthenewimportantplayersinwomensgynecologicalhealth AT violettadymickapiekarska sirtuinsthenewimportantplayersinwomensgynecologicalhealth AT agnieszkapiwowar sirtuinsthenewimportantplayersinwomensgynecologicalhealth |