Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling

Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling

Multiple myeloma is an incurable plasma cell malignancy with only a 53% 5-year survival rate. There is a critical need to find new multiple myeloma vulnerabilities and therapeutic avenues. Herein, we identified and explored a novel multiple myeloma target: the fatty acid binding protein (FABP) famil...

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Bibliographic Details
Main Authors: Mariah Farrell, Heather Fairfield, Michelle Karam, Anastasia D'Amico, Connor S Murphy, Carolyne Falank, Romanos Sklavenitis Pistofidi, Amanda Cao, Catherine R Marinac, Julie A Dragon, Lauren McGuinness, Carlos G Gartner, Reagan Di Iorio, Edward Jachimowicz, Victoria DeMambro, Calvin Vary, Michaela R Reagan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
myeloma
fatty acid binding protein
FABP
FABP5
RNA-Seq
proteomics
Online Access:https://elifesciences.org/articles/81184

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