mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration
mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/1/187 |
| _version_ | 1827599823839166464 |
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| author | Palas K. Chanda Roman Sukhovershin John P. Cooke |
| author_facet | Palas K. Chanda Roman Sukhovershin John P. Cooke |
| author_sort | Palas K. Chanda |
| collection | DOAJ |
| description | mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration. |
| first_indexed | 2024-03-09T04:23:04Z |
| format | Article |
| id | doaj.art-8d7b0214d9cd419784df169a42c0f00c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T04:23:04Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8d7b0214d9cd419784df169a42c0f00c2023-12-03T13:44:52ZengMDPI AGCells2073-44092021-01-0110118710.3390/cells10010187mRNA-Enhanced Cell Therapy and Cardiovascular RegenerationPalas K. Chanda0Roman Sukhovershin1John P. Cooke2RNA Therapeutics Program, Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USARNA Therapeutics Program, Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USARNA Therapeutics Program, Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USAmRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.https://www.mdpi.com/2073-4409/10/1/187RNA therapeuticscell therapycardiovascular regenerationinflammatory signalingnuclear reprogrammingiPSCs |
| spellingShingle | Palas K. Chanda Roman Sukhovershin John P. Cooke mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration Cells RNA therapeutics cell therapy cardiovascular regeneration inflammatory signaling nuclear reprogramming iPSCs |
| title | mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration |
| title_full | mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration |
| title_fullStr | mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration |
| title_full_unstemmed | mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration |
| title_short | mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration |
| title_sort | mrna enhanced cell therapy and cardiovascular regeneration |
| topic | RNA therapeutics cell therapy cardiovascular regeneration inflammatory signaling nuclear reprogramming iPSCs |
| url | https://www.mdpi.com/2073-4409/10/1/187 |
| work_keys_str_mv | AT palaskchanda mrnaenhancedcelltherapyandcardiovascularregeneration AT romansukhovershin mrnaenhancedcelltherapyandcardiovascularregeneration AT johnpcooke mrnaenhancedcelltherapyandcardiovascularregeneration |