Clinical Value and Prognosis of C Reactive Protein to Lymphocyte Ratio in Severe Aneurysmal Subarachnoid Hemorrhage
ObjectiveTo investigate the relationship between CLR and disease severity and clinical prognosis of aSAH.MethodsThe authors retrospectively analyzed the clinical data of 221 patients with aSAH, who were admitted to the intensive care unit from January 2017 to December 2020. The indicators of inflamm...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.868764/full |
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| author | Qingqing Zhang Qingqing Zhang Gaoqi Zhang Gaoqi Zhang Lintao Wang Wanwan Zhang Wanwan Zhang Fandi Hou Zhanqiang Zheng Yong Guo Zhongcan Chen Zhongcan Chen Juha Hernesniemi Hugo Andrade-Barazarte Guang Feng Guang Feng Jianjun Gu Jianjun Gu |
| author_facet | Qingqing Zhang Qingqing Zhang Gaoqi Zhang Gaoqi Zhang Lintao Wang Wanwan Zhang Wanwan Zhang Fandi Hou Zhanqiang Zheng Yong Guo Zhongcan Chen Zhongcan Chen Juha Hernesniemi Hugo Andrade-Barazarte Guang Feng Guang Feng Jianjun Gu Jianjun Gu |
| author_sort | Qingqing Zhang |
| collection | DOAJ |
| description | ObjectiveTo investigate the relationship between CLR and disease severity and clinical prognosis of aSAH.MethodsThe authors retrospectively analyzed the clinical data of 221 patients with aSAH, who were admitted to the intensive care unit from January 2017 to December 2020. The indicators of inflammatory factors in the first blood routine examination within 48 h of bleeding were obtained. The prognosis was evaluated by mRS score at discharge, mRS>2 was a poor outcome. Through the receiver operating characteristic (ROC) curve, the area under the curve was calculated and the predicted values of inflammatory factors (CLR, CRP, WBC, and neutrophils) were compared. Univariate and multivariable logistic regression analyses were used to evaluate the relationship between CLR and the clinical prognosis of patients. ROC curve analysis was performed to determine the optimal cut-off threshold, sensitivity, and specificity of CLR in predicting prognosis at admission.ResultsAccording to the mRS score at discharge, 139 (62.90%) patients were classified with poor outcomes (mRS>2). The inflammatory factor with the best predictive value was CLR, which had an optimal cut-off threshold of 10.81 and an area under the ROC curve of 0.840 (95%CI.788–0.892, P < 0.001). Multivariable Logistic regression analysis showed that the Modified Fisher grade, Hunt-Hess grade, and CLR at admission were independent risk factors for poor outcomes of patients with aSAH (P < 0.05). According to Hunt-Hess grade, patients were divided into a mild group (Hunt-Hess ≤ 3) and a severe group (Hunt-Hess > 3), and the CLR value was significantly higher in severe patients with aSAH than in mild patients. The optimal cut-off threshold of CLR in the severe group was 6.87, and the area under the ROC curve was 0.838 (95% CI.752–0.925, P < 0.001).ConclusionsThe CLR value at the admission of patients with aSAH was significantly associated with Hunt-Hess grade, The higher Hunt-Hess grade, the higher the CL R-value, and the worse the prognosis. Early CLR value can be considered as a feasible biomarker to predict the clinical prognosis of patients with aSAH. |
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| language | English |
| last_indexed | 2024-04-11T15:42:43Z |
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| series | Frontiers in Neurology |
| spelling | doaj.art-8d7baf67dbb94949a3aa2a902a0292c72022-12-22T04:15:44ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-06-011310.3389/fneur.2022.868764868764Clinical Value and Prognosis of C Reactive Protein to Lymphocyte Ratio in Severe Aneurysmal Subarachnoid HemorrhageQingqing Zhang0Qingqing Zhang1Gaoqi Zhang2Gaoqi Zhang3Lintao Wang4Wanwan Zhang5Wanwan Zhang6Fandi Hou7Zhanqiang Zheng8Yong Guo9Zhongcan Chen10Zhongcan Chen11Juha Hernesniemi12Hugo Andrade-Barazarte13Guang Feng14Guang Feng15Jianjun Gu16Jianjun Gu17Department of Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, ChinaSchool of Clinical Medicine, Henan University, Kaifeng, ChinaDepartment of Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, ChinaSchool of Clinical Medicine, Henan University, Kaifeng, ChinaSchool of Clinical Medicine, Henan University, Kaifeng, ChinaDepartment of Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, ChinaSchool of Clinical Medicine, Henan University, Kaifeng, ChinaDepartment of Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, ChinaDepartment of Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, ChinaDepartment of Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, ChinaDepartment of Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, ChinaDepartment of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, ChinaDepartment of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, ChinaDepartment of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, ChinaDepartment of Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, ChinaDepartment of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, ChinaDepartment of Neurosurgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, ChinaSchool of Clinical Medicine, Henan University, Kaifeng, ChinaObjectiveTo investigate the relationship between CLR and disease severity and clinical prognosis of aSAH.MethodsThe authors retrospectively analyzed the clinical data of 221 patients with aSAH, who were admitted to the intensive care unit from January 2017 to December 2020. The indicators of inflammatory factors in the first blood routine examination within 48 h of bleeding were obtained. The prognosis was evaluated by mRS score at discharge, mRS>2 was a poor outcome. Through the receiver operating characteristic (ROC) curve, the area under the curve was calculated and the predicted values of inflammatory factors (CLR, CRP, WBC, and neutrophils) were compared. Univariate and multivariable logistic regression analyses were used to evaluate the relationship between CLR and the clinical prognosis of patients. ROC curve analysis was performed to determine the optimal cut-off threshold, sensitivity, and specificity of CLR in predicting prognosis at admission.ResultsAccording to the mRS score at discharge, 139 (62.90%) patients were classified with poor outcomes (mRS>2). The inflammatory factor with the best predictive value was CLR, which had an optimal cut-off threshold of 10.81 and an area under the ROC curve of 0.840 (95%CI.788–0.892, P < 0.001). Multivariable Logistic regression analysis showed that the Modified Fisher grade, Hunt-Hess grade, and CLR at admission were independent risk factors for poor outcomes of patients with aSAH (P < 0.05). According to Hunt-Hess grade, patients were divided into a mild group (Hunt-Hess ≤ 3) and a severe group (Hunt-Hess > 3), and the CLR value was significantly higher in severe patients with aSAH than in mild patients. The optimal cut-off threshold of CLR in the severe group was 6.87, and the area under the ROC curve was 0.838 (95% CI.752–0.925, P < 0.001).ConclusionsThe CLR value at the admission of patients with aSAH was significantly associated with Hunt-Hess grade, The higher Hunt-Hess grade, the higher the CL R-value, and the worse the prognosis. Early CLR value can be considered as a feasible biomarker to predict the clinical prognosis of patients with aSAH.https://www.frontiersin.org/articles/10.3389/fneur.2022.868764/fullaneurysmal subarachnoid hemorrhage (aSAH)C-reactive protein (CRP)lymphocytesC-reactive protein to lymphocyte ratio (CLR)prognosisoutcome |
| spellingShingle | Qingqing Zhang Qingqing Zhang Gaoqi Zhang Gaoqi Zhang Lintao Wang Wanwan Zhang Wanwan Zhang Fandi Hou Zhanqiang Zheng Yong Guo Zhongcan Chen Zhongcan Chen Juha Hernesniemi Hugo Andrade-Barazarte Guang Feng Guang Feng Jianjun Gu Jianjun Gu Clinical Value and Prognosis of C Reactive Protein to Lymphocyte Ratio in Severe Aneurysmal Subarachnoid Hemorrhage Frontiers in Neurology aneurysmal subarachnoid hemorrhage (aSAH) C-reactive protein (CRP) lymphocytes C-reactive protein to lymphocyte ratio (CLR) prognosis outcome |
| title | Clinical Value and Prognosis of C Reactive Protein to Lymphocyte Ratio in Severe Aneurysmal Subarachnoid Hemorrhage |
| title_full | Clinical Value and Prognosis of C Reactive Protein to Lymphocyte Ratio in Severe Aneurysmal Subarachnoid Hemorrhage |
| title_fullStr | Clinical Value and Prognosis of C Reactive Protein to Lymphocyte Ratio in Severe Aneurysmal Subarachnoid Hemorrhage |
| title_full_unstemmed | Clinical Value and Prognosis of C Reactive Protein to Lymphocyte Ratio in Severe Aneurysmal Subarachnoid Hemorrhage |
| title_short | Clinical Value and Prognosis of C Reactive Protein to Lymphocyte Ratio in Severe Aneurysmal Subarachnoid Hemorrhage |
| title_sort | clinical value and prognosis of c reactive protein to lymphocyte ratio in severe aneurysmal subarachnoid hemorrhage |
| topic | aneurysmal subarachnoid hemorrhage (aSAH) C-reactive protein (CRP) lymphocytes C-reactive protein to lymphocyte ratio (CLR) prognosis outcome |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.868764/full |
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