Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Targeted drug conjugates based on Affibody molecules fused to an albumin-binding domain (ABD) for half-life extension have demonstrated potent anti-tumor activity in preclinical therapeutic studies. Furthermore, optimization of their molecular design might increase the cytotoxic effect on tumors and...

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Bibliographic Details
Main Authors:	Tianqi Xu, Jie Zhang, Maryam Oroujeni, Maria S. Tretyakova, Vitalina Bodenko, Mikhail V. Belousov, Anna Orlova, Vladimir Tolmachev, Anzhelika Vorobyeva, Torbjörn Gräslund
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Pharmaceutics
Subjects:	affibody molecule human epidermal growth factor receptor 2 HER2 SKOV3 emtansine DM1
Online Access:	https://www.mdpi.com/1999-4923/14/3/522

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