The next generation of sinus stents for chronic rhinosinusitis: A systematic review
Characterized by impaired mucociliary clearance with subsequent compromised microbial elimination, chronic rhinosinusitis (CRS) is known as a multifactorial disease process in which bacterial infection or colonization could play a role in the initiation or propagation of the inflammatory response. V...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Sungkyunkwan University School of Medi
2022-09-01
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| Series: | Precision and Future Medicine |
| Subjects: | |
| Online Access: | http://pfmjournal.org/upload/pdf/pfm-2022-00065.pdf |
| _version_ | 1811342130429296640 |
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| author | Dong-Jin Lim Do-Yeon Cho |
| author_facet | Dong-Jin Lim Do-Yeon Cho |
| author_sort | Dong-Jin Lim |
| collection | DOAJ |
| description | Characterized by impaired mucociliary clearance with subsequent compromised microbial elimination, chronic rhinosinusitis (CRS) is known as a multifactorial disease process in which bacterial infection or colonization could play a role in the initiation or propagation of the inflammatory response. Various non-systemic, topical therapies have recently emerged as an alternative to conventional oral regimens in managing CRS. A topical sinonasal drug delivery system using a bioabsorbable stent represents one of the most attractive methods among multiple topical delivery options. This review discusses the commercially available topical drug delivery platform (sinus stents) for CRS and its shortcomings. Based on the current drawbacks of sinus stents, this article has also highlighted the future developmental perspectives to create the next generation of a sinus stent, thereby harnessing the full potential of the sinus stent as efficient topical drug delivery for recalcitrant CRS. |
| first_indexed | 2024-04-13T19:06:04Z |
| format | Article |
| id | doaj.art-8d7d5494a12d4d71b0bd8f5a6aa0e248 |
| institution | Directory Open Access Journal |
| issn | 2508-7940 2508-7959 |
| language | English |
| last_indexed | 2024-04-13T19:06:04Z |
| publishDate | 2022-09-01 |
| publisher | Sungkyunkwan University School of Medi |
| record_format | Article |
| series | Precision and Future Medicine |
| spelling | doaj.art-8d7d5494a12d4d71b0bd8f5a6aa0e2482022-12-22T02:33:58ZengSungkyunkwan University School of MediPrecision and Future Medicine2508-79402508-79592022-09-016316116910.23838/pfm.2022.00065128The next generation of sinus stents for chronic rhinosinusitis: A systematic reviewDong-Jin Lim0Do-Yeon Cho1 Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USACharacterized by impaired mucociliary clearance with subsequent compromised microbial elimination, chronic rhinosinusitis (CRS) is known as a multifactorial disease process in which bacterial infection or colonization could play a role in the initiation or propagation of the inflammatory response. Various non-systemic, topical therapies have recently emerged as an alternative to conventional oral regimens in managing CRS. A topical sinonasal drug delivery system using a bioabsorbable stent represents one of the most attractive methods among multiple topical delivery options. This review discusses the commercially available topical drug delivery platform (sinus stents) for CRS and its shortcomings. Based on the current drawbacks of sinus stents, this article has also highlighted the future developmental perspectives to create the next generation of a sinus stent, thereby harnessing the full potential of the sinus stent as efficient topical drug delivery for recalcitrant CRS.http://pfmjournal.org/upload/pdf/pfm-2022-00065.pdfbacterial infectionsbiodegradable implantsdrug delivery systemsinusitisstents |
| spellingShingle | Dong-Jin Lim Do-Yeon Cho The next generation of sinus stents for chronic rhinosinusitis: A systematic review Precision and Future Medicine bacterial infections biodegradable implants drug delivery system sinusitis stents |
| title | The next generation of sinus stents for chronic rhinosinusitis: A systematic review |
| title_full | The next generation of sinus stents for chronic rhinosinusitis: A systematic review |
| title_fullStr | The next generation of sinus stents for chronic rhinosinusitis: A systematic review |
| title_full_unstemmed | The next generation of sinus stents for chronic rhinosinusitis: A systematic review |
| title_short | The next generation of sinus stents for chronic rhinosinusitis: A systematic review |
| title_sort | next generation of sinus stents for chronic rhinosinusitis a systematic review |
| topic | bacterial infections biodegradable implants drug delivery system sinusitis stents |
| url | http://pfmjournal.org/upload/pdf/pfm-2022-00065.pdf |
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