LIPOPROTEIN(A) LEVELS IN A POPULATION WITH ESTABLISHED ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN THE UNITED STATES: A SUB-ANALYSIS FROM THE LP(A)HERITAGE STUDY
Therapeutic Area: ASCVD/CVD Risk Reduction Background: Elevated lipoprotein(a) [Lp(a)] is the most common inherited dyslipidemia leading to an increased risk of atherosclerotic cardiovascular disease (ASCVD). Several cohort studies have reported elevated Lp(a) prevalence in the general population; h...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | American Journal of Preventive Cardiology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666667723000934 |
| _version_ | 1797676564429668352 |
|---|---|
| author | Michael D. Shapiro Tariq M. Haddad Howard S. Weintraub Seth J. Baum Khaled AbdulNour Vadim Paluy Wess Boatwright Auris Browne Imran Ayaz Cheryl A. Abbas Christie M. Ballantyne |
| author_facet | Michael D. Shapiro Tariq M. Haddad Howard S. Weintraub Seth J. Baum Khaled AbdulNour Vadim Paluy Wess Boatwright Auris Browne Imran Ayaz Cheryl A. Abbas Christie M. Ballantyne |
| author_sort | Michael D. Shapiro |
| collection | DOAJ |
| description | Therapeutic Area: ASCVD/CVD Risk Reduction Background: Elevated lipoprotein(a) [Lp(a)] is the most common inherited dyslipidemia leading to an increased risk of atherosclerotic cardiovascular disease (ASCVD). Several cohort studies have reported elevated Lp(a) prevalence in the general population; however, there is a paucity of data in those with established ASCVD. This sub-analysis of the Lp(a)HERITAGE study (NCT03887520) assessed Lp(a) levels in United States (US) participants with ASCVD, stratified by race, ethnicity, and sex. Methods: This cross-sectional study assessed the prevalence of elevated Lp(a) in adult participants (18–80 years of age) with a history of myocardial infarction or ischemic stroke ≥3 months to ≤10 years prior to enrollment (April 2019–July 2021) or symptomatic peripheral artery disease, across 192 US sites. Lp(a) and low-density lipid-cholesterol (LDL-C) levels were obtained using US central laboratory or historical data. Results: In total, 8,295 US participants were enrolled. The sub-analysis included 7,679 participants with Lp(a) measured in nmol/L, of which 66.4% were male, 80.5% were White, 16.9% were Black, and 8.0% had Hispanic ethnicity. Compared with the overall population, median Lp(a) was >2.5-fold higher in Black participants (132.0 vs 52.1 nmol/L) and was 21.8% lower in Hispanic participants (40.7 vs 52.1 nmol/L); in females, median Lp(a) levels were >1.5-fold higher than in male participants (69.4 vs 45.6 nmol/L) (Table). Overall, 33.3% of participants had Lp(a) ≥125 nmol/L. Prevalence of Lp(a) ≥125 nmol/L was highest among Black participants (52.0%) and lowest among Hispanic participants (25.6%); a greater proportion of females had Lp(a) ≥125 nmol/L compared with males (38.9% vs 30.4%) (Table). Conclusions: In the Lp(a)HERITAGE study, 33.3% of US participants with established ASCVD had Lp(a) levels ≥125 nmol/L. Compared with the overall population, the proportion of patients with Lp(a) ≥125 nmol/L was higher in Black (52.0%) and female (38.9%) participants and was lower in Hispanic participants (25.6%). These findings support more aggressive Lp(a) screening strategies among patients with established ASCVD, particularly female or Black patients. Furthermore, elevated Lp(a) levels can be used to inform the intensification of lifestyle and other risk factor management in clinical practice and may have implications for potential future therapies targeting Lp(a). |
| first_indexed | 2024-03-11T22:31:02Z |
| format | Article |
| id | doaj.art-8d7dd21bc5624b9791f2cab6f92bbfb4 |
| institution | Directory Open Access Journal |
| issn | 2666-6677 |
| language | English |
| last_indexed | 2024-03-11T22:31:02Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Preventive Cardiology |
| spelling | doaj.art-8d7dd21bc5624b9791f2cab6f92bbfb42023-09-23T05:13:00ZengElsevierAmerican Journal of Preventive Cardiology2666-66772023-09-0115100552LIPOPROTEIN(A) LEVELS IN A POPULATION WITH ESTABLISHED ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN THE UNITED STATES: A SUB-ANALYSIS FROM THE LP(A)HERITAGE STUDYMichael D. Shapiro0Tariq M. Haddad1Howard S. Weintraub2Seth J. Baum3Khaled AbdulNour4Vadim Paluy5Wess Boatwright6Auris Browne7Imran Ayaz8Cheryl A. Abbas9Christie M. Ballantyne10Section on Cardiovascular Medicine, Center for Prevention of Cardiovascular Disease, Wake Forest University School of Medicine, Winston-Salem, NC, USAVirginia Heart, Falls Church, VA, USA; Inova Heart and Vascular Institute, Falls Church, VA, USANew York University Grossman School of Medicine, New York University Center for the Prevention of Cardiovascular Disease, NY, USAFlourish Research, Boca Raton, FL, USADivision of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USANovartis Pharmaceutical Corporation, East Hanover, NJ, USANovartis Pharmaceutical Corporation, East Hanover, NJ, USANovartis Pharmaceutical Corporation, East Hanover, NJ, USANovartis Pharmaceutical Corporation, East Hanover, NJ, USANovartis Pharma AG, Basel, SwitzerlandSection of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX, USATherapeutic Area: ASCVD/CVD Risk Reduction Background: Elevated lipoprotein(a) [Lp(a)] is the most common inherited dyslipidemia leading to an increased risk of atherosclerotic cardiovascular disease (ASCVD). Several cohort studies have reported elevated Lp(a) prevalence in the general population; however, there is a paucity of data in those with established ASCVD. This sub-analysis of the Lp(a)HERITAGE study (NCT03887520) assessed Lp(a) levels in United States (US) participants with ASCVD, stratified by race, ethnicity, and sex. Methods: This cross-sectional study assessed the prevalence of elevated Lp(a) in adult participants (18–80 years of age) with a history of myocardial infarction or ischemic stroke ≥3 months to ≤10 years prior to enrollment (April 2019–July 2021) or symptomatic peripheral artery disease, across 192 US sites. Lp(a) and low-density lipid-cholesterol (LDL-C) levels were obtained using US central laboratory or historical data. Results: In total, 8,295 US participants were enrolled. The sub-analysis included 7,679 participants with Lp(a) measured in nmol/L, of which 66.4% were male, 80.5% were White, 16.9% were Black, and 8.0% had Hispanic ethnicity. Compared with the overall population, median Lp(a) was >2.5-fold higher in Black participants (132.0 vs 52.1 nmol/L) and was 21.8% lower in Hispanic participants (40.7 vs 52.1 nmol/L); in females, median Lp(a) levels were >1.5-fold higher than in male participants (69.4 vs 45.6 nmol/L) (Table). Overall, 33.3% of participants had Lp(a) ≥125 nmol/L. Prevalence of Lp(a) ≥125 nmol/L was highest among Black participants (52.0%) and lowest among Hispanic participants (25.6%); a greater proportion of females had Lp(a) ≥125 nmol/L compared with males (38.9% vs 30.4%) (Table). Conclusions: In the Lp(a)HERITAGE study, 33.3% of US participants with established ASCVD had Lp(a) levels ≥125 nmol/L. Compared with the overall population, the proportion of patients with Lp(a) ≥125 nmol/L was higher in Black (52.0%) and female (38.9%) participants and was lower in Hispanic participants (25.6%). These findings support more aggressive Lp(a) screening strategies among patients with established ASCVD, particularly female or Black patients. Furthermore, elevated Lp(a) levels can be used to inform the intensification of lifestyle and other risk factor management in clinical practice and may have implications for potential future therapies targeting Lp(a).http://www.sciencedirect.com/science/article/pii/S2666667723000934 |
| spellingShingle | Michael D. Shapiro Tariq M. Haddad Howard S. Weintraub Seth J. Baum Khaled AbdulNour Vadim Paluy Wess Boatwright Auris Browne Imran Ayaz Cheryl A. Abbas Christie M. Ballantyne LIPOPROTEIN(A) LEVELS IN A POPULATION WITH ESTABLISHED ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN THE UNITED STATES: A SUB-ANALYSIS FROM THE LP(A)HERITAGE STUDY American Journal of Preventive Cardiology |
| title | LIPOPROTEIN(A) LEVELS IN A POPULATION WITH ESTABLISHED ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN THE UNITED STATES: A SUB-ANALYSIS FROM THE LP(A)HERITAGE STUDY |
| title_full | LIPOPROTEIN(A) LEVELS IN A POPULATION WITH ESTABLISHED ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN THE UNITED STATES: A SUB-ANALYSIS FROM THE LP(A)HERITAGE STUDY |
| title_fullStr | LIPOPROTEIN(A) LEVELS IN A POPULATION WITH ESTABLISHED ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN THE UNITED STATES: A SUB-ANALYSIS FROM THE LP(A)HERITAGE STUDY |
| title_full_unstemmed | LIPOPROTEIN(A) LEVELS IN A POPULATION WITH ESTABLISHED ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN THE UNITED STATES: A SUB-ANALYSIS FROM THE LP(A)HERITAGE STUDY |
| title_short | LIPOPROTEIN(A) LEVELS IN A POPULATION WITH ESTABLISHED ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN THE UNITED STATES: A SUB-ANALYSIS FROM THE LP(A)HERITAGE STUDY |
| title_sort | lipoprotein a levels in a population with established atherosclerotic cardiovascular disease in the united states a sub analysis from the lp a heritage study |
| url | http://www.sciencedirect.com/science/article/pii/S2666667723000934 |
| work_keys_str_mv | AT michaeldshapiro lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy AT tariqmhaddad lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy AT howardsweintraub lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy AT sethjbaum lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy AT khaledabdulnour lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy AT vadimpaluy lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy AT wessboatwright lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy AT aurisbrowne lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy AT imranayaz lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy AT cherylaabbas lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy AT christiemballantyne lipoproteinalevelsinapopulationwithestablishedatheroscleroticcardiovasculardiseaseintheunitedstatesasubanalysisfromthelpaheritagestudy |