Metabolomics Pilot Study Identifies Desynchronization of 24-H Rhythms and Distinct Intra-patient Variability Patterns in Critical Illness: A Preliminary Report

Metabolomics Pilot Study Identifies Desynchronization of 24-H Rhythms and Distinct Intra-patient Variability Patterns in Critical Illness: A Preliminary Report

Background: Synchronized circadian rhythms play a key role in coordinating physiologic health. Desynchronized circadian rhythms may predispose individuals to disease or be indicative of underlying disease. Intensive care unit (ICU) patients likely experience desynchronized circadian rhythms due to d...

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Bibliographic Details
Main Authors: Elizabeth R. Lusczek, Lee S. Parsons, Jesse Elder, Stephen B. Harvey, Mariya Skube, Sydne Muratore, Greg Beilman, Germaine Cornelissen-Guillaume
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neurology
Subjects:
circadian rhythms
metabolomics
critical illness
ICU—intensive care unit
cortisol (Cor)
precision medicine
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.533915/full

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