Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review
Diabetes Mellitus is a highly prevalent disease in Mexico and in the world, among whose complications is diabetic neuropathy. DN is a group of disorders that present signs and/or symptoms of peripheral nerve dysfunction and have different clinical manifestations in both peripheral neuropathy and aut...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-02-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/27/2/10.31083/j.fbl2702057 |
| _version_ | 1818355268141973504 |
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| author | Rebeca Kababie-Ameo Griselda Mericia Rabadán-Chávez Natalia Vázquez-Manjarrez Gabriela Gutiérrez-Salmeán |
| author_facet | Rebeca Kababie-Ameo Griselda Mericia Rabadán-Chávez Natalia Vázquez-Manjarrez Gabriela Gutiérrez-Salmeán |
| author_sort | Rebeca Kababie-Ameo |
| collection | DOAJ |
| description | Diabetes Mellitus is a highly prevalent disease in Mexico and in the world, among whose complications is diabetic neuropathy. DN is a group of disorders that present signs and/or symptoms of peripheral nerve dysfunction and have different clinical manifestations in both peripheral neuropathy and autonomic neuropathy. As a part of the mechanisms by which DN develops, oxidative stress and inflammation have been described. Cocoa is a plant origin product which includes around 300 components and through different studies, it has been suggested that cocoa has different mechanisms of action through which exerts its beneficial effects on health. It has been proposed that cocoa has hypoglycemic, lipid-lowering, antioxidant and anti-inflammatory effects, and thus, potentially have a beneficial direct or indirect effect on diabetic neuropathy. Specially in preclinical studies, the anti-inflammatory and anti-nociceptive effect of cocoa has been evaluated through different mechanisms of action. However, most of the studies presented concerning this complication, are in vitro or preclinical studies, so there is still a great area of opportunity regarding the use of cocoa on diabetic neuropathy. |
| first_indexed | 2024-12-13T19:38:37Z |
| format | Article |
| id | doaj.art-8d7fb315a7144be99d966c01f295bd26 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-13T19:38:37Z |
| publishDate | 2022-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-8d7fb315a7144be99d966c01f295bd262022-12-21T23:33:45ZengIMR PressFrontiers in Bioscience-Landmark2768-67012022-02-0127205710.31083/j.fbl2702057S2768-6701(22)00395-1Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-reviewRebeca Kababie-Ameo0Griselda Mericia Rabadán-Chávez1Natalia Vázquez-Manjarrez2Gabriela Gutiérrez-Salmeán3Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac México, 52786 Huixquilucan, Estado de México, MexicoDepartamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 07738 Gustavo A. Madero, CDMX, MexicoDirección de Investigación, Instituto Nacional de Nutrición y Ciencias Médicas Salvador Zubirán, 14080 Tlalpan, CDMX, MexicoCentro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac México, 52786 Huixquilucan, Estado de México, MexicoDiabetes Mellitus is a highly prevalent disease in Mexico and in the world, among whose complications is diabetic neuropathy. DN is a group of disorders that present signs and/or symptoms of peripheral nerve dysfunction and have different clinical manifestations in both peripheral neuropathy and autonomic neuropathy. As a part of the mechanisms by which DN develops, oxidative stress and inflammation have been described. Cocoa is a plant origin product which includes around 300 components and through different studies, it has been suggested that cocoa has different mechanisms of action through which exerts its beneficial effects on health. It has been proposed that cocoa has hypoglycemic, lipid-lowering, antioxidant and anti-inflammatory effects, and thus, potentially have a beneficial direct or indirect effect on diabetic neuropathy. Specially in preclinical studies, the anti-inflammatory and anti-nociceptive effect of cocoa has been evaluated through different mechanisms of action. However, most of the studies presented concerning this complication, are in vitro or preclinical studies, so there is still a great area of opportunity regarding the use of cocoa on diabetic neuropathy.https://www.imrpress.com/journal/FBL/27/2/10.31083/j.fbl2702057diabetic neuropathycacaococoainflammationoxidative stress |
| spellingShingle | Rebeca Kababie-Ameo Griselda Mericia Rabadán-Chávez Natalia Vázquez-Manjarrez Gabriela Gutiérrez-Salmeán Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review Frontiers in Bioscience-Landmark diabetic neuropathy cacao cocoa inflammation oxidative stress |
| title | Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review |
| title_full | Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review |
| title_fullStr | Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review |
| title_full_unstemmed | Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review |
| title_short | Potential applications of cocoa (Theobroma cacao) on diabetic neuropathy: mini-review |
| title_sort | potential applications of cocoa theobroma cacao on diabetic neuropathy mini review |
| topic | diabetic neuropathy cacao cocoa inflammation oxidative stress |
| url | https://www.imrpress.com/journal/FBL/27/2/10.31083/j.fbl2702057 |
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