Primary angiocentric/angioinvasive T-cell lymphoma of the tympanic bulla in a feline leukaemia virus-positive cat
Case summary A 5-year-old neutered female feline leukaemia virus (FeLV)-positive domestic shorthair cat with a 5 month history of otitis media was referred for head tilt, stertor and dyspnoea. Computed tomography scan revealed soft tissue opacities inside the right tympanic bulla, with bone remodell...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-07-01
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| Series: | Journal of Feline Medicine and Surgery Open Reports |
| Online Access: | https://doi.org/10.1177/2055116915593966 |
| _version_ | 1828966093998260224 |
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| author | Sara F Santagostino Carlo M Mortellaro Julia Buchholz Margherita Lugli Annalisa Forlani Gabriele Ghisleni Paola Roccabianca |
| author_facet | Sara F Santagostino Carlo M Mortellaro Julia Buchholz Margherita Lugli Annalisa Forlani Gabriele Ghisleni Paola Roccabianca |
| author_sort | Sara F Santagostino |
| collection | DOAJ |
| description | Case summary A 5-year-old neutered female feline leukaemia virus (FeLV)-positive domestic shorthair cat with a 5 month history of otitis media was referred for head tilt, stertor and dyspnoea. Computed tomography scan revealed soft tissue opacities inside the right tympanic bulla, with bone remodelling, and concurrent nasopharyngeal and intracranial invasion. Endoscopically guided bioptic samples were collected from the nasopharynx and middle ear. Histology revealed dense sheets of round, large, neoplastic cells, often surrounding or invading vascular walls. Neoplastic cells expressed CD3, FeLV p27 and gp70 antigens. A middle ear angiocentric/angioinvasive T-cell lymphoma was diagnosed. After improvement of clinical conditions following radiation therapy, the cat died unexpectedly. At necropsy, hepatic and splenic spread was detected. Relevance and novel information Primary middle ear tumours are rare and their diagnosis is often delayed as clinical signs mimic more common otological conditions. Multiple bioptic specimens are pivotal for a definitive diagnosis. The young age of the cat, serology and immunohistochemistry revealed a possible transforming role of FeLV. |
| first_indexed | 2024-12-14T11:25:06Z |
| format | Article |
| id | doaj.art-8d7fcaf2a3fd41c5b18c06ce4b46a479 |
| institution | Directory Open Access Journal |
| issn | 2055-1169 |
| language | English |
| last_indexed | 2024-12-14T11:25:06Z |
| publishDate | 2015-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Feline Medicine and Surgery Open Reports |
| spelling | doaj.art-8d7fcaf2a3fd41c5b18c06ce4b46a4792022-12-21T23:03:34ZengSAGE PublishingJournal of Feline Medicine and Surgery Open Reports2055-11692015-07-01110.1177/205511691559396610.1177_2055116915593966Primary angiocentric/angioinvasive T-cell lymphoma of the tympanic bulla in a feline leukaemia virus-positive catSara F Santagostino0Carlo M Mortellaro1Julia Buchholz2Margherita Lugli3Annalisa Forlani4Gabriele Ghisleni5Paola Roccabianca6Department of Veterinary Science and Public Health, Faculty of Veterinary Medicine, University of Milan, Milan, ItalyDepartment of Veterinary Science and Public Health, Faculty of Veterinary Medicine, University of Milan, Milan, ItalyAnimal Oncology and Imaging Center, Zurich, SwitzerlandDepartment of Veterinary Science and Public Health, Faculty of Veterinary Medicine, University of Milan, Milan, ItalyDepartment of Veterinary Science and Public Health, Faculty of Veterinary Medicine, University of Milan, Milan, ItalyDepartment of Veterinary Science and Public Health, Faculty of Veterinary Medicine, University of Milan, Milan, ItalyDepartment of Veterinary Science and Public Health, Faculty of Veterinary Medicine, University of Milan, Milan, ItalyCase summary A 5-year-old neutered female feline leukaemia virus (FeLV)-positive domestic shorthair cat with a 5 month history of otitis media was referred for head tilt, stertor and dyspnoea. Computed tomography scan revealed soft tissue opacities inside the right tympanic bulla, with bone remodelling, and concurrent nasopharyngeal and intracranial invasion. Endoscopically guided bioptic samples were collected from the nasopharynx and middle ear. Histology revealed dense sheets of round, large, neoplastic cells, often surrounding or invading vascular walls. Neoplastic cells expressed CD3, FeLV p27 and gp70 antigens. A middle ear angiocentric/angioinvasive T-cell lymphoma was diagnosed. After improvement of clinical conditions following radiation therapy, the cat died unexpectedly. At necropsy, hepatic and splenic spread was detected. Relevance and novel information Primary middle ear tumours are rare and their diagnosis is often delayed as clinical signs mimic more common otological conditions. Multiple bioptic specimens are pivotal for a definitive diagnosis. The young age of the cat, serology and immunohistochemistry revealed a possible transforming role of FeLV.https://doi.org/10.1177/2055116915593966 |
| spellingShingle | Sara F Santagostino Carlo M Mortellaro Julia Buchholz Margherita Lugli Annalisa Forlani Gabriele Ghisleni Paola Roccabianca Primary angiocentric/angioinvasive T-cell lymphoma of the tympanic bulla in a feline leukaemia virus-positive cat Journal of Feline Medicine and Surgery Open Reports |
| title | Primary angiocentric/angioinvasive T-cell lymphoma of the tympanic bulla in a feline leukaemia virus-positive cat |
| title_full | Primary angiocentric/angioinvasive T-cell lymphoma of the tympanic bulla in a feline leukaemia virus-positive cat |
| title_fullStr | Primary angiocentric/angioinvasive T-cell lymphoma of the tympanic bulla in a feline leukaemia virus-positive cat |
| title_full_unstemmed | Primary angiocentric/angioinvasive T-cell lymphoma of the tympanic bulla in a feline leukaemia virus-positive cat |
| title_short | Primary angiocentric/angioinvasive T-cell lymphoma of the tympanic bulla in a feline leukaemia virus-positive cat |
| title_sort | primary angiocentric angioinvasive t cell lymphoma of the tympanic bulla in a feline leukaemia virus positive cat |
| url | https://doi.org/10.1177/2055116915593966 |
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