Apolipoprotein B level and diabetic microvascular complications ( is there a correlation?)
IntroductionDyslipidemia has long been implicated in diabetic complications. However, many subgroups have been considered to be responsible. Furthermore, a cause and effect relationship has long been debated. Apolipoprotein B (Apo B) is an exact measure of the total number of very low-density lipopr...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2013-01-01
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| Series: | The Egyptian Journal of Internal Medicine |
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| Online Access: | http://www.esim.eg.net/article.asp?issn=1110-7782;year=2013;volume=25;issue=3;spage=137;epage=142;aulast=Rizk |
| _version_ | 1818656030536499200 |
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| author | Mary N. Rizk Hala Aly Pierre Samir Hala el Mofty Osama K. Allah |
| author_facet | Mary N. Rizk Hala Aly Pierre Samir Hala el Mofty Osama K. Allah |
| author_sort | Mary N. Rizk |
| collection | DOAJ |
| description | IntroductionDyslipidemia has long been implicated in diabetic complications. However, many subgroups have been considered to be responsible. Furthermore, a cause and effect relationship has long been debated. Apolipoprotein B (Apo B) is an exact measure of the total number of very low-density lipoprotein and low-density lipoprotein particles; thus, total plasma Apo B is a reliable surrogate for actual low-density lipoprotein particle number irrespective of its size. Hence, it is a better indicator of the correlation between dyslipidemia and diabetic microvascular complications.
Aim of the workOur aim is to study the correlation between Apo B and diabetic microvascular complications, namely, nephropathy and retinopathy.
Materials and methodsA cross sectional study was carried out of 56 diabetic patients, 36 men and 20 women, both type 1 and 2, who were chosen randomly from the outpatient Endocrinology Clinic in Cairo University. Serum creatinine, estimated glomerular filtration rate, urine albumin/creatinine ratio (A/C ratio), and Apo B levels were determined. Groups were divided according to the A/C ratio as follows: no proteinuria (A/C ratio<30 mg/g), incipient proteinuria (30-300 mg/g), and overt proteinuria (>300 mg/g). We performed fundus examination as well as fluorescein angiography in patients with retinopathy. Patients on dialysis, HBA1c more than 7.5, on lipid-lowering treatment, or with familial hyperlipidemia were excluded. Calculations were carried out using the SPSS v.10 statistical software.
Results We found a significant positive correlation between Apo B levels and microvascular complications. Apo B was higher with overt nephropathy than incipient nephropathy (1.75±0.38), and higher in patients with incipient nephropathy (1.4±0.48) than in patients without nephropathy (1.02±0.34, P<0.01).
A highly significant correlation was detected between the grades of retinopathy and the Apo B level. Finally, a significant positive correlation was detected between the presence of maculopathy and Apo B. Apo B levels were significantly higher in the presence of both nephropathy and retinopathy (1.26±0.389) than in the absence of both complications (0.77±0.361, P<0.05).
Conclusion Apo B levels are strongly correlated to diabetic microvascular complications. The higher the degree of nephropathy, the higher the Apo B level. The presence of more than one microvascular complication correlates positively with high levels of Apo B. This suggests the possible use of Apo B as a sensitive biomarker of the presence of early diabetic microvascular complications. |
| first_indexed | 2024-12-17T03:19:06Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1110-7782 2090-9098 |
| language | English |
| last_indexed | 2024-12-17T03:19:06Z |
| publishDate | 2013-01-01 |
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| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj.art-8d7fe192a37f4ef591d2ede38a24f0712022-12-21T22:05:34ZengSpringerOpenThe Egyptian Journal of Internal Medicine1110-77822090-90982013-01-0125313714210.7123/01.EJIM.0000432236.92356.43Apolipoprotein B level and diabetic microvascular complications ( is there a correlation?)Mary N. RizkHala AlyPierre SamirHala el MoftyOsama K. AllahIntroductionDyslipidemia has long been implicated in diabetic complications. However, many subgroups have been considered to be responsible. Furthermore, a cause and effect relationship has long been debated. Apolipoprotein B (Apo B) is an exact measure of the total number of very low-density lipoprotein and low-density lipoprotein particles; thus, total plasma Apo B is a reliable surrogate for actual low-density lipoprotein particle number irrespective of its size. Hence, it is a better indicator of the correlation between dyslipidemia and diabetic microvascular complications. Aim of the workOur aim is to study the correlation between Apo B and diabetic microvascular complications, namely, nephropathy and retinopathy. Materials and methodsA cross sectional study was carried out of 56 diabetic patients, 36 men and 20 women, both type 1 and 2, who were chosen randomly from the outpatient Endocrinology Clinic in Cairo University. Serum creatinine, estimated glomerular filtration rate, urine albumin/creatinine ratio (A/C ratio), and Apo B levels were determined. Groups were divided according to the A/C ratio as follows: no proteinuria (A/C ratio<30 mg/g), incipient proteinuria (30-300 mg/g), and overt proteinuria (>300 mg/g). We performed fundus examination as well as fluorescein angiography in patients with retinopathy. Patients on dialysis, HBA1c more than 7.5, on lipid-lowering treatment, or with familial hyperlipidemia were excluded. Calculations were carried out using the SPSS v.10 statistical software. Results We found a significant positive correlation between Apo B levels and microvascular complications. Apo B was higher with overt nephropathy than incipient nephropathy (1.75±0.38), and higher in patients with incipient nephropathy (1.4±0.48) than in patients without nephropathy (1.02±0.34, P<0.01). A highly significant correlation was detected between the grades of retinopathy and the Apo B level. Finally, a significant positive correlation was detected between the presence of maculopathy and Apo B. Apo B levels were significantly higher in the presence of both nephropathy and retinopathy (1.26±0.389) than in the absence of both complications (0.77±0.361, P<0.05). Conclusion Apo B levels are strongly correlated to diabetic microvascular complications. The higher the degree of nephropathy, the higher the Apo B level. The presence of more than one microvascular complication correlates positively with high levels of Apo B. This suggests the possible use of Apo B as a sensitive biomarker of the presence of early diabetic microvascular complications.http://www.esim.eg.net/article.asp?issn=1110-7782;year=2013;volume=25;issue=3;spage=137;epage=142;aulast=Rizkapolipoprotein B, diabetic nephropathy, hyperlipidemia, retinopathy |
| spellingShingle | Mary N. Rizk Hala Aly Pierre Samir Hala el Mofty Osama K. Allah Apolipoprotein B level and diabetic microvascular complications ( is there a correlation?) The Egyptian Journal of Internal Medicine apolipoprotein B, diabetic nephropathy, hyperlipidemia, retinopathy |
| title | Apolipoprotein B level and diabetic microvascular complications ( is there a correlation?) |
| title_full | Apolipoprotein B level and diabetic microvascular complications ( is there a correlation?) |
| title_fullStr | Apolipoprotein B level and diabetic microvascular complications ( is there a correlation?) |
| title_full_unstemmed | Apolipoprotein B level and diabetic microvascular complications ( is there a correlation?) |
| title_short | Apolipoprotein B level and diabetic microvascular complications ( is there a correlation?) |
| title_sort | apolipoprotein b level and diabetic microvascular complications is there a correlation |
| topic | apolipoprotein B, diabetic nephropathy, hyperlipidemia, retinopathy |
| url | http://www.esim.eg.net/article.asp?issn=1110-7782;year=2013;volume=25;issue=3;spage=137;epage=142;aulast=Rizk |
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