Environmental manipulations generate bidirectional shifts in both behavior and gene regulation in a crossbred mouse model of extremes in trait anxiety

Environmental manipulations generate bidirectional shifts in both behavior and gene regulation in a crossbred mouse model of extremes in trait anxiety

Although gene-environment interactions are known to significantly influence psychopathology-related disease states, only few animal models cover both the genetic background and environmental manipulations. Therefore, we have taken advantage of the bidirectionally inbred high (HAB) and low (LAB) anxi...

Full description

Bibliographic Details
Main Authors: Natalia Yu. Chekmareva, Sergey V. Sotnikov, Rebekka P. Diepold, Roshan R. Naik, Rainer eLandgraf, Ludwig eCzibere
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Gene Expression
anxiety-related behavior
enriched environment
Chronic mild stress
allele-specificity
Crhr1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00087/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00087/full

Similar Items