The Rehabilitation Potential of Neurostimulation for Mild Traumatic Brain Injury in Animal and Human Studies
Neurostimulation carries high therapeutic potential, accompanied by an excellent safety profile. In this review, we argue that an arena in which these tools could provide breakthrough benefits is traumatic brain injury (TBI). TBI is a major health problem worldwide, with the majority of cases identi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/10/1402 |
| _version_ | 1797574521847283712 |
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| author | M. Windy McNerney Gene G. Gurkoff Charlotte Beard Marian E. Berryhill |
| author_facet | M. Windy McNerney Gene G. Gurkoff Charlotte Beard Marian E. Berryhill |
| author_sort | M. Windy McNerney |
| collection | DOAJ |
| description | Neurostimulation carries high therapeutic potential, accompanied by an excellent safety profile. In this review, we argue that an arena in which these tools could provide breakthrough benefits is traumatic brain injury (TBI). TBI is a major health problem worldwide, with the majority of cases identified as mild TBI (mTBI). MTBI is of concern because it is a modifiable risk factor for dementia. A major challenge in studying mTBI is its inherent <i>heterogeneity</i> across a large feature space (e.g., etiology, age of injury, sex, treatment, initial health status, etc.). Parallel lines of research in human and rodent mTBI can be collated to take advantage of the full suite of neuroscience tools, from neuroimaging (electroencephalography: EEG; functional magnetic resonance imaging: fMRI; diffusion tensor imaging: DTI) to biochemical assays. Despite these attractive components and the need for effective treatments, there are at least two major challenges to implementation. First, there is insufficient understanding of how neurostimulation alters neural mechanisms. Second, there is insufficient understanding of how mTBI alters neural function. The goal of this review is to assemble interrelated but disparate areas of research to identify important gaps in knowledge impeding the implementation of neurostimulation. |
| first_indexed | 2024-03-10T21:23:39Z |
| format | Article |
| id | doaj.art-8d8268eee665469e891ac53996c9134a |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T21:23:39Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-8d8268eee665469e891ac53996c9134a2023-11-19T15:52:26ZengMDPI AGBrain Sciences2076-34252023-09-011310140210.3390/brainsci13101402The Rehabilitation Potential of Neurostimulation for Mild Traumatic Brain Injury in Animal and Human StudiesM. Windy McNerney0Gene G. Gurkoff1Charlotte Beard2Marian E. Berryhill3Mental Illness Research Education and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USADepartment of Neurological Surgery, and Center for Neuroscience, University of California, Davis, Sacramento, CA 95817, USAMental Illness Research Education and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USAPrograms in Cognitive and Brain Sciences, and Integrative Neuroscience, Department of Psychology, University of Nevada, Reno, NV 89557, USANeurostimulation carries high therapeutic potential, accompanied by an excellent safety profile. In this review, we argue that an arena in which these tools could provide breakthrough benefits is traumatic brain injury (TBI). TBI is a major health problem worldwide, with the majority of cases identified as mild TBI (mTBI). MTBI is of concern because it is a modifiable risk factor for dementia. A major challenge in studying mTBI is its inherent <i>heterogeneity</i> across a large feature space (e.g., etiology, age of injury, sex, treatment, initial health status, etc.). Parallel lines of research in human and rodent mTBI can be collated to take advantage of the full suite of neuroscience tools, from neuroimaging (electroencephalography: EEG; functional magnetic resonance imaging: fMRI; diffusion tensor imaging: DTI) to biochemical assays. Despite these attractive components and the need for effective treatments, there are at least two major challenges to implementation. First, there is insufficient understanding of how neurostimulation alters neural mechanisms. Second, there is insufficient understanding of how mTBI alters neural function. The goal of this review is to assemble interrelated but disparate areas of research to identify important gaps in knowledge impeding the implementation of neurostimulation.https://www.mdpi.com/2076-3425/13/10/1402traumatic brain injuryrTMSneuromodulationrodent modelcognitive neuroscienceexecutive function |
| spellingShingle | M. Windy McNerney Gene G. Gurkoff Charlotte Beard Marian E. Berryhill The Rehabilitation Potential of Neurostimulation for Mild Traumatic Brain Injury in Animal and Human Studies Brain Sciences traumatic brain injury rTMS neuromodulation rodent model cognitive neuroscience executive function |
| title | The Rehabilitation Potential of Neurostimulation for Mild Traumatic Brain Injury in Animal and Human Studies |
| title_full | The Rehabilitation Potential of Neurostimulation for Mild Traumatic Brain Injury in Animal and Human Studies |
| title_fullStr | The Rehabilitation Potential of Neurostimulation for Mild Traumatic Brain Injury in Animal and Human Studies |
| title_full_unstemmed | The Rehabilitation Potential of Neurostimulation for Mild Traumatic Brain Injury in Animal and Human Studies |
| title_short | The Rehabilitation Potential of Neurostimulation for Mild Traumatic Brain Injury in Animal and Human Studies |
| title_sort | rehabilitation potential of neurostimulation for mild traumatic brain injury in animal and human studies |
| topic | traumatic brain injury rTMS neuromodulation rodent model cognitive neuroscience executive function |
| url | https://www.mdpi.com/2076-3425/13/10/1402 |
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