Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis
Serkan Dundar,1 Abubekir Eltas,2 Sema S Hakki,3 Sıddık Malkoc,4 M Ozay Uslu,2 Mehmet Tuzcu,5 James Komorowski,6 I Hanifi Ozercan,7 Fatih Akdemir,8 Kazim Sahin9 1Department of Periodontology, Faculty of Dentistry, Firat University, Elazig, 2Department of Periodontology, Faculty of Dentistry, Inonu U...
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Dove Medical Press
2016-11-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/dietary-arginine-silicate-inositol-complex-inhibits-periodontal-tissue-peer-reviewed-article-DDDT |
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| author | Dundar S Eltas A Hakki SS Malkoc S Uslu MO Tuzcu M Komorowski J Ozercan IH Akdemir F Sahin K |
| author_facet | Dundar S Eltas A Hakki SS Malkoc S Uslu MO Tuzcu M Komorowski J Ozercan IH Akdemir F Sahin K |
| author_sort | Dundar S |
| collection | DOAJ |
| description | Serkan Dundar,1 Abubekir Eltas,2 Sema S Hakki,3 Sıddık Malkoc,4 M Ozay Uslu,2 Mehmet Tuzcu,5 James Komorowski,6 I Hanifi Ozercan,7 Fatih Akdemir,8 Kazim Sahin9 1Department of Periodontology, Faculty of Dentistry, Firat University, Elazig, 2Department of Periodontology, Faculty of Dentistry, Inonu University, Malatya, 3Department of Periodontology, Faculty of Dentistry, Selcuk University, Konya, 4Department of Orthodontics, Faculty of Dentistry, Inonu University, Malatya, 5Department of Biology, Faculty of Science, Firat University, Elazig, Turkey; 6Research & Development, Nutrition 21 Inc., Purchase, NY, USA; 7Department of Pathology, Faculty of Medicine, 8Department of Animal Nutrition, Faculty of Fisheries, Inonu University, Malatya, 9Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey Abstract: The purpose of this study was to induce experimental periodontitis in rats previously fed diets containing arginine silicate inositol (ASI) complex and examine the biochemical, immunological, and radiological effects. Fifty two 8-week-old female Sprague Dawley rats were equally divided into four groups. The control group included those fed a standard rat diet with no operation performed during the experiment. The periodontitis, ASI I, and ASI II groups were subjected to experimental periodontitis induction for 11 days after being fed a standard rat diet alone, a diet containing 1.81 g/kg ASI complex, or a diet containing 3.62 g/kg ASI complex, respectively, for 8 weeks. Throughout the 11-day duration of periodontitis induction, all rats were fed standard feed. The rats were euthanized on the eleventh day, and their tissue and blood samples were collected. In the periodontitis group, elevated tissue destruction parameters and reduced tissue formation parameters were found, as compared to the ASI groups. Levels of enzymes, cytokines, and mediators associated with periodontal tissue destruction were lower in rats fed a diet containing ASI complex after experimental periodontitis. These results indicate that ASI complex could be an alternative agent for host modulation. Keywords: arginine silicate inositol complex, experimental periodontitis, host modulation, micro-computed tomography, periodontal infection |
| first_indexed | 2024-12-13T04:58:01Z |
| format | Article |
| id | doaj.art-8d8295169fca4b24b59dd0ab485cea56 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-13T04:58:01Z |
| publishDate | 2016-11-01 |
| publisher | Dove Medical Press |
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| series | Drug Design, Development and Therapy |
| spelling | doaj.art-8d8295169fca4b24b59dd0ab485cea562022-12-21T23:58:50ZengDove Medical PressDrug Design, Development and Therapy1177-88812016-11-01Volume 103771377830049Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitisDundar SEltas AHakki SSMalkoc SUslu MOTuzcu MKomorowski JOzercan IHAkdemir FSahin KSerkan Dundar,1 Abubekir Eltas,2 Sema S Hakki,3 Sıddık Malkoc,4 M Ozay Uslu,2 Mehmet Tuzcu,5 James Komorowski,6 I Hanifi Ozercan,7 Fatih Akdemir,8 Kazim Sahin9 1Department of Periodontology, Faculty of Dentistry, Firat University, Elazig, 2Department of Periodontology, Faculty of Dentistry, Inonu University, Malatya, 3Department of Periodontology, Faculty of Dentistry, Selcuk University, Konya, 4Department of Orthodontics, Faculty of Dentistry, Inonu University, Malatya, 5Department of Biology, Faculty of Science, Firat University, Elazig, Turkey; 6Research & Development, Nutrition 21 Inc., Purchase, NY, USA; 7Department of Pathology, Faculty of Medicine, 8Department of Animal Nutrition, Faculty of Fisheries, Inonu University, Malatya, 9Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey Abstract: The purpose of this study was to induce experimental periodontitis in rats previously fed diets containing arginine silicate inositol (ASI) complex and examine the biochemical, immunological, and radiological effects. Fifty two 8-week-old female Sprague Dawley rats were equally divided into four groups. The control group included those fed a standard rat diet with no operation performed during the experiment. The periodontitis, ASI I, and ASI II groups were subjected to experimental periodontitis induction for 11 days after being fed a standard rat diet alone, a diet containing 1.81 g/kg ASI complex, or a diet containing 3.62 g/kg ASI complex, respectively, for 8 weeks. Throughout the 11-day duration of periodontitis induction, all rats were fed standard feed. The rats were euthanized on the eleventh day, and their tissue and blood samples were collected. In the periodontitis group, elevated tissue destruction parameters and reduced tissue formation parameters were found, as compared to the ASI groups. Levels of enzymes, cytokines, and mediators associated with periodontal tissue destruction were lower in rats fed a diet containing ASI complex after experimental periodontitis. These results indicate that ASI complex could be an alternative agent for host modulation. Keywords: arginine silicate inositol complex, experimental periodontitis, host modulation, micro-computed tomography, periodontal infectionhttps://www.dovepress.com/dietary-arginine-silicate-inositol-complex-inhibits-periodontal-tissue-peer-reviewed-article-DDDTArginine silicate inositol complexexperimental periodontitishost modulationmicro-computerized tomographyperiodontal infection. |
| spellingShingle | Dundar S Eltas A Hakki SS Malkoc S Uslu MO Tuzcu M Komorowski J Ozercan IH Akdemir F Sahin K Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis Drug Design, Development and Therapy Arginine silicate inositol complex experimental periodontitis host modulation micro-computerized tomography periodontal infection. |
| title | Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis |
| title_full | Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis |
| title_fullStr | Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis |
| title_full_unstemmed | Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis |
| title_short | Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis |
| title_sort | dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature induced periodontitis |
| topic | Arginine silicate inositol complex experimental periodontitis host modulation micro-computerized tomography periodontal infection. |
| url | https://www.dovepress.com/dietary-arginine-silicate-inositol-complex-inhibits-periodontal-tissue-peer-reviewed-article-DDDT |
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