Lactate and Mortality in the Intensive Care Unit
Purpose: In our study, we aimed to assess the relationship between the initial value of blood lactate levels and mortality rate in ICU patients with sepsis. Materials and Methods: Our study was conducted as a retrospective study, and patients admitted to the Anesthesiology Intensive Care Unit wit...
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| Format: | Article |
| Language: | English |
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Kirsehir Ahi Evran University
2022-08-01
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| Series: | Ahi Evran Medical Journal |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1852314 |
| _version_ | 1797924125402988544 |
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| author | Esra ÇAKIR Işıl ÖZKOÇAK TURAN |
| author_facet | Esra ÇAKIR Işıl ÖZKOÇAK TURAN |
| author_sort | Esra ÇAKIR |
| collection | DOAJ |
| description | Purpose: In our study, we aimed to assess the relationship between the initial value of blood lactate levels and mortality rate in ICU patients with sepsis.
Materials and Methods: Our study was conducted as a retrospective study, and patients admitted to the Anesthesiology Intensive Care Unit with sepsis diagnosis were included. Demographic and clinical characteristics of patients' data were collected and recorded from patients’ medical records. Blood lactate levels were obtained from all patients. Demographic and clinical characteristics and blood lactate levels compared between the mortality occurring and a non-mortality groups of patients. A receiver-operating characteristic (ROC) curve was constructed to assess the best blood lactate level cutoff to predict the mortality rate and diagnostic value of this cutoff level.
Results: During the study period, 892 patients were admitted to ICU and 218 of those with sepsis were included in the study. The area under the ROC curve to predict the mortality rate of blood lactate level was 0.862 (95% CI: 0.809–0.905) (p= 0.0001). The blood lactate cutoff level related to mortality was found to be 2.7 mmol / L (sensitivity: 90.3%, 95% CI: 82.4–95.5, specificity: 72.8%, CI:64.1–80.4).
Conclusion: Lactate levels are important indicator for predicting mortality in patients with sepsis in the hospitals and ICUs. Close follow-up for lactate levels may change the treatment modality and clinical outcome during hospitalization. |
| first_indexed | 2024-04-10T14:56:42Z |
| format | Article |
| id | doaj.art-8d83cd3b06924f54a12e574bef5d70fd |
| institution | Directory Open Access Journal |
| issn | 2619-9203 |
| language | English |
| last_indexed | 2024-04-10T14:56:42Z |
| publishDate | 2022-08-01 |
| publisher | Kirsehir Ahi Evran University |
| record_format | Article |
| series | Ahi Evran Medical Journal |
| spelling | doaj.art-8d83cd3b06924f54a12e574bef5d70fd2023-02-15T16:07:20ZengKirsehir Ahi Evran UniversityAhi Evran Medical Journal2619-92032022-08-016211512010.46332/aemj.960131Lactate and Mortality in the Intensive Care UnitEsra ÇAKIR0https://orcid.org/0000-0002-6992-5744Işıl ÖZKOÇAK TURAN1https://orcid.org/0000-0002-0405-0107ANKARA NUMUNE SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİSAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA NUMUNE SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜPurpose: In our study, we aimed to assess the relationship between the initial value of blood lactate levels and mortality rate in ICU patients with sepsis. Materials and Methods: Our study was conducted as a retrospective study, and patients admitted to the Anesthesiology Intensive Care Unit with sepsis diagnosis were included. Demographic and clinical characteristics of patients' data were collected and recorded from patients’ medical records. Blood lactate levels were obtained from all patients. Demographic and clinical characteristics and blood lactate levels compared between the mortality occurring and a non-mortality groups of patients. A receiver-operating characteristic (ROC) curve was constructed to assess the best blood lactate level cutoff to predict the mortality rate and diagnostic value of this cutoff level. Results: During the study period, 892 patients were admitted to ICU and 218 of those with sepsis were included in the study. The area under the ROC curve to predict the mortality rate of blood lactate level was 0.862 (95% CI: 0.809–0.905) (p= 0.0001). The blood lactate cutoff level related to mortality was found to be 2.7 mmol / L (sensitivity: 90.3%, 95% CI: 82.4–95.5, specificity: 72.8%, CI:64.1–80.4). Conclusion: Lactate levels are important indicator for predicting mortality in patients with sepsis in the hospitals and ICUs. Close follow-up for lactate levels may change the treatment modality and clinical outcome during hospitalization. https://dergipark.org.tr/tr/download/article-file/1852314intensive care unit;mortalitylactatesepsis |
| spellingShingle | Esra ÇAKIR Işıl ÖZKOÇAK TURAN Lactate and Mortality in the Intensive Care Unit Ahi Evran Medical Journal intensive care unit; mortality lactate sepsis |
| title | Lactate and Mortality in the Intensive Care Unit |
| title_full | Lactate and Mortality in the Intensive Care Unit |
| title_fullStr | Lactate and Mortality in the Intensive Care Unit |
| title_full_unstemmed | Lactate and Mortality in the Intensive Care Unit |
| title_short | Lactate and Mortality in the Intensive Care Unit |
| title_sort | lactate and mortality in the intensive care unit |
| topic | intensive care unit; mortality lactate sepsis |
| url | https://dergipark.org.tr/tr/download/article-file/1852314 |
| work_keys_str_mv | AT esracakir lactateandmortalityintheintensivecareunit AT isılozkocakturan lactateandmortalityintheintensivecareunit |