Deletion of p75NTR rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer’s disease

Deletion of p75NTR rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer’s disease

IntroductionAlzheimer’s disease (AD), is characterized by a gradual cognitive decline associated with the accumulation of Amyloid beta (Aβ)-oligomers, progressive neuronal degeneration and chronic neuroinflammation. Among the receptors shown to bind and possibly transduce the toxic effects of Aβ-oli...

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Bibliographic Details
Main Authors: Hendrik Demuth, Shirin Hosseini, Henning Peter Düsedeau, Ildiko Rita Dunay, Martin Korte, Marta Zagrebelsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s’s disease
neuroinflammation
p75 neurotrophin receptor
synaptic plasticity
spatial learning
cognitive decline
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1163087/full

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