Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating
A compact and label-free optical fiber sensor based on a taper interferometer cascaded with a fiber Bragg grating (FBG) is proposed and experimentally demonstrated for detection of a breast cancer biomarker (HER2). The tapered fiber-optic interferometer is extremely sensitive to the ambient refracti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/17/11/2559 |
| _version_ | 1828153771595661312 |
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| author | Dandan Sun Yang Ran Guanjun Wang |
| author_facet | Dandan Sun Yang Ran Guanjun Wang |
| author_sort | Dandan Sun |
| collection | DOAJ |
| description | A compact and label-free optical fiber sensor based on a taper interferometer cascaded with a fiber Bragg grating (FBG) is proposed and experimentally demonstrated for detection of a breast cancer biomarker (HER2). The tapered fiber-optic interferometer is extremely sensitive to the ambient refractive index (RI). In addition, being insensitive to the RI variation, the FBG can be applied as a temperature thermometer due to its independent response to the temperature. Surface functionalization to the sensor is carried out to achieve specific targeting of the unlabeled biomarkers. The result shows that the proposed sensor presents a low limit-of-detection (LOD) of 2 ng/mL, enabling its potentials of application in early diagnosis on the breast cancer. |
| first_indexed | 2024-04-11T22:30:23Z |
| format | Article |
| id | doaj.art-8d86c892bb024b5d96e7c9a7d6209aeb |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T22:30:23Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-8d86c892bb024b5d96e7c9a7d6209aeb2022-12-22T03:59:29ZengMDPI AGSensors1424-82202017-11-011711255910.3390/s17112559s17112559Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg GratingDandan Sun0Yang Ran1Guanjun Wang2College of Physics and Electronic Engineering, Shanxi University, Taiyuan 030006, ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, ChinaSchool of Information and Communication Engineering, North University of China, Taiyuan 030051, ChinaA compact and label-free optical fiber sensor based on a taper interferometer cascaded with a fiber Bragg grating (FBG) is proposed and experimentally demonstrated for detection of a breast cancer biomarker (HER2). The tapered fiber-optic interferometer is extremely sensitive to the ambient refractive index (RI). In addition, being insensitive to the RI variation, the FBG can be applied as a temperature thermometer due to its independent response to the temperature. Surface functionalization to the sensor is carried out to achieve specific targeting of the unlabeled biomarkers. The result shows that the proposed sensor presents a low limit-of-detection (LOD) of 2 ng/mL, enabling its potentials of application in early diagnosis on the breast cancer.https://www.mdpi.com/1424-8220/17/11/2559fiber taper interferometerFBGoptical biosensorcancer biomarker |
| spellingShingle | Dandan Sun Yang Ran Guanjun Wang Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating Sensors fiber taper interferometer FBG optical biosensor cancer biomarker |
| title | Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating |
| title_full | Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating |
| title_fullStr | Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating |
| title_full_unstemmed | Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating |
| title_short | Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating |
| title_sort | label free detection of cancer biomarkers using an in line taper fiber optic interferometer and a fiber bragg grating |
| topic | fiber taper interferometer FBG optical biosensor cancer biomarker |
| url | https://www.mdpi.com/1424-8220/17/11/2559 |
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