Synthesis of a Coumarin-Based PPARγ Fluorescence Probe for Competitive Binding Assay

Synthesis of a Coumarin-Based PPARγ Fluorescence Probe for Competitive Binding Assay

Peroxisome proliferator-activated receptor γ (PPARγ) is a molecular target of metabolic syndrome and inflammatory disease. PPARγ is an important nuclear receptor and numerous PPARγ ligands were developed to date; thus, efficient assay methods are important. Here, we investigated the incorporation of...

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Bibliographic Details
Main Authors: Chisato Yoshikawa, Hiroaki Ishida, Nami Ohashi, Toshimasa Itoh
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
PPARγ ligand
coumarin
fluorescent ligand
screening
crystal structure
Online Access:https://www.mdpi.com/1422-0067/22/8/4034

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