Comparing Complications of Biologic and Synthetic Mesh in Breast Reconstruction: A Systematic Review and Network Meta-Analysis
Background In breast reconstruction, synthetic meshes are frequently used to replace acellular dermal matrix (ADM), since ADM is expensive and often leads to complications. However, there is limited evidence that compares the types of substitutes. This study aimed to compare complications between ma...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2023-01-01
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| Series: | Archives of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1964-8181 |
| _version_ | 1811166469956829184 |
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| author | Young-Soo Choi Hi-Jin You Tae-Yul Lee Deok-Woo Kim |
| author_facet | Young-Soo Choi Hi-Jin You Tae-Yul Lee Deok-Woo Kim |
| author_sort | Young-Soo Choi |
| collection | DOAJ |
| description | Background In breast reconstruction, synthetic meshes are frequently used to replace acellular dermal matrix (ADM), since ADM is expensive and often leads to complications. However, there is limited evidence that compares the types of substitutes. This study aimed to compare complications between materials via a network meta-analysis.
Methods We systematically reviewed studies reporting any type of complication from 2010 to 2021. The primary outcomes were the proportion of infection, seroma, major complications, or contracture. We classified the intervention into four categories: ADM, absorbable mesh, nonabsorbable mesh, and nothing used. We then performed a network meta-analysis between these categories and estimated the odds ratio with random-effect models.
Results Of 603 searched studies through the PubMed, MEDLINE, and Embase databases, following their review by two independent reviewers, 61 studies were included for full-text reading, of which 17 studies were finally included. There was a low risk of bias in the included studies, but only an indirect comparison between absorbable and non-absorbable mesh was possible. Infection was more frequent in ADM but not in the two synthetic mesh groups, namely the absorbable or nonabsorbable types, compared with the nonmesh group. The proportion of seroma in the synthetic mesh group was lower (odds ratio was 0.2 for the absorbable and 0.1 for the nonabsorbable mesh group) than in the ADM group. Proportions of major complications and contractures did not significantly differ between groups.
Conclusion Compared with ADM, synthetic meshes have low infection and seroma rates. However, more studies concerning aesthetic outcomes and direct comparisons are needed. |
| first_indexed | 2024-04-10T15:52:58Z |
| format | Article |
| id | doaj.art-8d875ab0fb8b481493bd59da1dc3aba5 |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-04-10T15:52:58Z |
| publishDate | 2023-01-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj.art-8d875ab0fb8b481493bd59da1dc3aba52023-02-11T00:01:43ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712023-01-01500100300910.1055/a-1964-8181Comparing Complications of Biologic and Synthetic Mesh in Breast Reconstruction: A Systematic Review and Network Meta-AnalysisYoung-Soo Choi0Hi-Jin You1Tae-Yul Lee2Deok-Woo Kim3Department of Plastic and Reconstructive Surgery, Korea University Ansan Hospital, Ansan, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, Korea University Ansan Hospital, Ansan, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, Korea University Ansan Hospital, Ansan, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, Korea University Ansan Hospital, Ansan, Republic of KoreaBackground In breast reconstruction, synthetic meshes are frequently used to replace acellular dermal matrix (ADM), since ADM is expensive and often leads to complications. However, there is limited evidence that compares the types of substitutes. This study aimed to compare complications between materials via a network meta-analysis. Methods We systematically reviewed studies reporting any type of complication from 2010 to 2021. The primary outcomes were the proportion of infection, seroma, major complications, or contracture. We classified the intervention into four categories: ADM, absorbable mesh, nonabsorbable mesh, and nothing used. We then performed a network meta-analysis between these categories and estimated the odds ratio with random-effect models. Results Of 603 searched studies through the PubMed, MEDLINE, and Embase databases, following their review by two independent reviewers, 61 studies were included for full-text reading, of which 17 studies were finally included. There was a low risk of bias in the included studies, but only an indirect comparison between absorbable and non-absorbable mesh was possible. Infection was more frequent in ADM but not in the two synthetic mesh groups, namely the absorbable or nonabsorbable types, compared with the nonmesh group. The proportion of seroma in the synthetic mesh group was lower (odds ratio was 0.2 for the absorbable and 0.1 for the nonabsorbable mesh group) than in the ADM group. Proportions of major complications and contractures did not significantly differ between groups. Conclusion Compared with ADM, synthetic meshes have low infection and seroma rates. However, more studies concerning aesthetic outcomes and direct comparisons are needed.http://www.thieme-connect.de/DOI/DOI?10.1055/a-1964-8181mammaplastysurgical meshnetwork meta-analysis |
| spellingShingle | Young-Soo Choi Hi-Jin You Tae-Yul Lee Deok-Woo Kim Comparing Complications of Biologic and Synthetic Mesh in Breast Reconstruction: A Systematic Review and Network Meta-Analysis Archives of Plastic Surgery mammaplasty surgical mesh network meta-analysis |
| title | Comparing Complications of Biologic and Synthetic Mesh in Breast Reconstruction: A Systematic Review and Network Meta-Analysis |
| title_full | Comparing Complications of Biologic and Synthetic Mesh in Breast Reconstruction: A Systematic Review and Network Meta-Analysis |
| title_fullStr | Comparing Complications of Biologic and Synthetic Mesh in Breast Reconstruction: A Systematic Review and Network Meta-Analysis |
| title_full_unstemmed | Comparing Complications of Biologic and Synthetic Mesh in Breast Reconstruction: A Systematic Review and Network Meta-Analysis |
| title_short | Comparing Complications of Biologic and Synthetic Mesh in Breast Reconstruction: A Systematic Review and Network Meta-Analysis |
| title_sort | comparing complications of biologic and synthetic mesh in breast reconstruction a systematic review and network meta analysis |
| topic | mammaplasty surgical mesh network meta-analysis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1964-8181 |
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