A Combination of Apple Vinegar Drink with <i>Bacillus coagulans</i> Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis
Obesity is a worldwide epidemic characterized by excessive fat accumulation, associated with multiple comorbidities and complications. Emerging evidence points to gut microbiome as a driving force in the pathogenesis of obesity. Vinegar intake, a traditional remedy source of exogenous acetate, has b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2504 |
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| author | Raquel Urtasun Joana Díaz-Gómez Miriam Araña María José Pajares María Oneca Paloma Torre Maddalen Jiménez Germán Munilla Miguel Barajas Ignacio Encío |
| author_facet | Raquel Urtasun Joana Díaz-Gómez Miriam Araña María José Pajares María Oneca Paloma Torre Maddalen Jiménez Germán Munilla Miguel Barajas Ignacio Encío |
| author_sort | Raquel Urtasun |
| collection | DOAJ |
| description | Obesity is a worldwide epidemic characterized by excessive fat accumulation, associated with multiple comorbidities and complications. Emerging evidence points to gut microbiome as a driving force in the pathogenesis of obesity. Vinegar intake, a traditional remedy source of exogenous acetate, has been shown to improve glycemic control and to have anti-obesity effects. New functional foods may be developed by supplementing traditional food with probiotics. <i>B. coagulans</i> is a suitable choice because of its resistance to high temperatures. To analyze the possible synergic effect of Vinegar and <i>B. coagulans</i> against the metabolic alterations induced by a high fat diet (HFD), we fed twelve-week-old C57BL/6 mice with HFD for 5 weeks after 2 weeks of acclimation on a normal diet. Then, food intake, body weight, blood biochemical parameters, histology and liver inflammatory markers were analyzed. Although vinegar drink, either alone or supplemented with <i>B. coagulans</i>, reduced food intake, attenuated body weight gain and enhanced glucose tolerance, only the supplemented drink improved the lipid serum profile and prevented hepatic HFD-induced overexpression of CD36, IL-1β, IL-6, LXR and SREBP, thus reducing lipid deposition in the liver. The beneficial properties of the <i>B. coagulans</i>-supplemented vinegar appear to be mediated by a reduction in insulin and leptin circulating levels. |
| first_indexed | 2024-03-10T17:11:12Z |
| format | Article |
| id | doaj.art-8d8a3959102b49c48e54cf2aee62c9a8 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T17:11:12Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8d8a3959102b49c48e54cf2aee62c9a82023-11-20T10:39:00ZengMDPI AGNutrients2072-66432020-08-01129250410.3390/nu12092504A Combination of Apple Vinegar Drink with <i>Bacillus coagulans</i> Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic SteatosisRaquel Urtasun0Joana Díaz-Gómez1Miriam Araña2María José Pajares3María Oneca4Paloma Torre5Maddalen Jiménez6Germán Munilla7Miguel Barajas8Ignacio Encío9Biochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, SpainEcovinal S.L., Pol. Ind Gobella, 1, 31589 Sartaguda, SpainBiochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, SpainBiochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, SpainBiochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, SpainNutrition and Bromatology area, Department of Natural Sciences, Public University of Navarre, 31006 Pamplona, SpainDivision of Hematological-Oncology, CIMA, University of Navarre, 31006 Pamplona, SpainEcovinal S.L., Pol. Ind Gobella, 1, 31589 Sartaguda, SpainBiochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, SpainBiochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, SpainObesity is a worldwide epidemic characterized by excessive fat accumulation, associated with multiple comorbidities and complications. Emerging evidence points to gut microbiome as a driving force in the pathogenesis of obesity. Vinegar intake, a traditional remedy source of exogenous acetate, has been shown to improve glycemic control and to have anti-obesity effects. New functional foods may be developed by supplementing traditional food with probiotics. <i>B. coagulans</i> is a suitable choice because of its resistance to high temperatures. To analyze the possible synergic effect of Vinegar and <i>B. coagulans</i> against the metabolic alterations induced by a high fat diet (HFD), we fed twelve-week-old C57BL/6 mice with HFD for 5 weeks after 2 weeks of acclimation on a normal diet. Then, food intake, body weight, blood biochemical parameters, histology and liver inflammatory markers were analyzed. Although vinegar drink, either alone or supplemented with <i>B. coagulans</i>, reduced food intake, attenuated body weight gain and enhanced glucose tolerance, only the supplemented drink improved the lipid serum profile and prevented hepatic HFD-induced overexpression of CD36, IL-1β, IL-6, LXR and SREBP, thus reducing lipid deposition in the liver. The beneficial properties of the <i>B. coagulans</i>-supplemented vinegar appear to be mediated by a reduction in insulin and leptin circulating levels.https://www.mdpi.com/2072-6643/12/9/2504obesityhigh fat dietinsulin resistancehepatic steatosisvinegar<i>Bacillus coagulans</i> |
| spellingShingle | Raquel Urtasun Joana Díaz-Gómez Miriam Araña María José Pajares María Oneca Paloma Torre Maddalen Jiménez Germán Munilla Miguel Barajas Ignacio Encío A Combination of Apple Vinegar Drink with <i>Bacillus coagulans</i> Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis Nutrients obesity high fat diet insulin resistance hepatic steatosis vinegar <i>Bacillus coagulans</i> |
| title | A Combination of Apple Vinegar Drink with <i>Bacillus coagulans</i> Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis |
| title_full | A Combination of Apple Vinegar Drink with <i>Bacillus coagulans</i> Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis |
| title_fullStr | A Combination of Apple Vinegar Drink with <i>Bacillus coagulans</i> Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis |
| title_full_unstemmed | A Combination of Apple Vinegar Drink with <i>Bacillus coagulans</i> Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis |
| title_short | A Combination of Apple Vinegar Drink with <i>Bacillus coagulans</i> Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis |
| title_sort | combination of apple vinegar drink with i bacillus coagulans i ameliorates high fat diet induced body weight gain insulin resistance and hepatic steatosis |
| topic | obesity high fat diet insulin resistance hepatic steatosis vinegar <i>Bacillus coagulans</i> |
| url | https://www.mdpi.com/2072-6643/12/9/2504 |
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