Prenatal folic acid supplement/dietary folate and cognitive development in 4-year-old offspring from the Japan Environment and Children’s Study
Abstract We evaluated the association between maternal prenatal folic acid supplement use/dietary folate intake and cognitive development in 4-year-old offspring (N = 3445) using data from the Japan Environment and Children’s Study. Cognitive development was evaluated using the Kyoto Scale of Psycho...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-36484-8 |
| _version_ | 1797801447976337408 |
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| author | Hidekazu Nishigori Toshie Nishigori Taku Obara Taeko Suzuki Miyuki Mori Karin Imaizumi Tsuyoshi Murata Hyo Kyozuka Yuka Ogata Akiko Sato Kosei Shinoki Seiji Yasumura Mitsuaki Hosoya Koichi Hashimoto Keiya Fujimori The Japan Environment and Children’s Study (JECS) Group |
| author_facet | Hidekazu Nishigori Toshie Nishigori Taku Obara Taeko Suzuki Miyuki Mori Karin Imaizumi Tsuyoshi Murata Hyo Kyozuka Yuka Ogata Akiko Sato Kosei Shinoki Seiji Yasumura Mitsuaki Hosoya Koichi Hashimoto Keiya Fujimori The Japan Environment and Children’s Study (JECS) Group |
| author_sort | Hidekazu Nishigori |
| collection | DOAJ |
| description | Abstract We evaluated the association between maternal prenatal folic acid supplement use/dietary folate intake and cognitive development in 4-year-old offspring (N = 3445) using data from the Japan Environment and Children’s Study. Cognitive development was evaluated using the Kyoto Scale of Psychological Development 2001. Multiple regression analysis revealed that offspring of mothers who started using folic acid supplements pre-conception had a significantly higher language-social developmental quotient (DQ) (partial regression coefficient 1.981, 95% confidence interval 0.091 to 3.872) than offspring of mothers who did not use such supplements at any time throughout their pregnancy (non-users). Offspring of mothers who started using folic acid supplements within 12 weeks of gestation had a significantly higher cognitive-adaptive (1.489, 0.312 to 2.667) and language-social (1.873, 0.586 to 3.159) DQ than offspring of non-users. Regarding daily dietary folate intake from preconception to early pregnancy, multiple regression analysis revealed that there was no significant association with any DQ area in the 200 to < 400 µg and the ≥ 400 µg groups compared with the < 200 µg group. Maternal prenatal folic acid supplementation starting within 12 weeks of gestation (but not adequate dietary folate intake from preconception to early pregnancy) is positively associated with cognitive development in 4-year-old offspring. |
| first_indexed | 2024-03-13T04:50:38Z |
| format | Article |
| id | doaj.art-8d8b109708af4d21967fefb63ce110e3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T04:50:38Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8d8b109708af4d21967fefb63ce110e32023-06-18T11:13:36ZengNature PortfolioScientific Reports2045-23222023-06-0113111410.1038/s41598-023-36484-8Prenatal folic acid supplement/dietary folate and cognitive development in 4-year-old offspring from the Japan Environment and Children’s StudyHidekazu Nishigori0Toshie Nishigori1Taku Obara2Taeko Suzuki3Miyuki Mori4Karin Imaizumi5Tsuyoshi Murata6Hyo Kyozuka7Yuka Ogata8Akiko Sato9Kosei Shinoki10Seiji Yasumura11Mitsuaki Hosoya12Koichi Hashimoto13Keiya Fujimori14The Japan Environment and Children’s Study (JECS) GroupDepartment of Development and Environmental Medicine, Fukushima Medical Center for Children and Women, Fukushima Medical University Graduate School of MedicineFukushima Regional Center for the Japan Environmental and Children’s StudyDepartment of Pharmaceutical Sciences, Tohoku University HospitalDepartment of Development and Environmental Medicine, Fukushima Medical Center for Children and Women, Fukushima Medical University Graduate School of MedicineDepartment of Development and Environmental Medicine, Fukushima Medical Center for Children and Women, Fukushima Medical University Graduate School of MedicineFukushima Regional Center for the Japan Environmental and Children’s StudyFukushima Regional Center for the Japan Environmental and Children’s StudyFukushima Regional Center for the Japan Environmental and Children’s StudyFukushima Regional Center for the Japan Environmental and Children’s StudyFukushima Regional Center for the Japan Environmental and Children’s StudyFukushima Regional Center for the Japan Environmental and Children’s StudyFukushima Regional Center for the Japan Environmental and Children’s StudyFukushima Regional Center for the Japan Environmental and Children’s StudyFukushima Regional Center for the Japan Environmental and Children’s StudyFukushima Regional Center for the Japan Environmental and Children’s StudyAbstract We evaluated the association between maternal prenatal folic acid supplement use/dietary folate intake and cognitive development in 4-year-old offspring (N = 3445) using data from the Japan Environment and Children’s Study. Cognitive development was evaluated using the Kyoto Scale of Psychological Development 2001. Multiple regression analysis revealed that offspring of mothers who started using folic acid supplements pre-conception had a significantly higher language-social developmental quotient (DQ) (partial regression coefficient 1.981, 95% confidence interval 0.091 to 3.872) than offspring of mothers who did not use such supplements at any time throughout their pregnancy (non-users). Offspring of mothers who started using folic acid supplements within 12 weeks of gestation had a significantly higher cognitive-adaptive (1.489, 0.312 to 2.667) and language-social (1.873, 0.586 to 3.159) DQ than offspring of non-users. Regarding daily dietary folate intake from preconception to early pregnancy, multiple regression analysis revealed that there was no significant association with any DQ area in the 200 to < 400 µg and the ≥ 400 µg groups compared with the < 200 µg group. Maternal prenatal folic acid supplementation starting within 12 weeks of gestation (but not adequate dietary folate intake from preconception to early pregnancy) is positively associated with cognitive development in 4-year-old offspring.https://doi.org/10.1038/s41598-023-36484-8 |
| spellingShingle | Hidekazu Nishigori Toshie Nishigori Taku Obara Taeko Suzuki Miyuki Mori Karin Imaizumi Tsuyoshi Murata Hyo Kyozuka Yuka Ogata Akiko Sato Kosei Shinoki Seiji Yasumura Mitsuaki Hosoya Koichi Hashimoto Keiya Fujimori The Japan Environment and Children’s Study (JECS) Group Prenatal folic acid supplement/dietary folate and cognitive development in 4-year-old offspring from the Japan Environment and Children’s Study Scientific Reports |
| title | Prenatal folic acid supplement/dietary folate and cognitive development in 4-year-old offspring from the Japan Environment and Children’s Study |
| title_full | Prenatal folic acid supplement/dietary folate and cognitive development in 4-year-old offspring from the Japan Environment and Children’s Study |
| title_fullStr | Prenatal folic acid supplement/dietary folate and cognitive development in 4-year-old offspring from the Japan Environment and Children’s Study |
| title_full_unstemmed | Prenatal folic acid supplement/dietary folate and cognitive development in 4-year-old offspring from the Japan Environment and Children’s Study |
| title_short | Prenatal folic acid supplement/dietary folate and cognitive development in 4-year-old offspring from the Japan Environment and Children’s Study |
| title_sort | prenatal folic acid supplement dietary folate and cognitive development in 4 year old offspring from the japan environment and children s study |
| url | https://doi.org/10.1038/s41598-023-36484-8 |
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