IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration

IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration

Abstract The influence of aging on intestinal stem cells and their niche can explain underlying causes for perturbation in their function observed during aging. Molecular mechanisms for such a decrease in the functionality of intestinal stem cells during aging remain largely undetermined. Using tran...

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Bibliographic Details
Main Authors: Omid Omrani, Anna Krepelova, Seyed Mohammad Mahdi Rasa, Dovydas Sirvinskas, Jing Lu, Francesco Annunziata, George Garside, Seerat Bajwa, Susanne Reinhardt, Lisa Adam, Sandra Käppel, Nadia Ducano, Daniela Donna, Alessandro Ori, Salvatore Oliviero, Karl Lenhard Rudolph, Francesco Neri
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41683-y

Internet

https://doi.org/10.1038/s41467-023-41683-y

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