PASylated Thymosin α1: A Long-Acting Immunostimulatory Peptide for Applications in Oncology and Virology

PASylated Thymosin α1: A Long-Acting Immunostimulatory Peptide for Applications in Oncology and Virology

Thymosin α1 (Tα1) is an immunostimulatory peptide for the treatment of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and used as an immune enhancer, which also offers prospects in the context of COVID-19 infections and cancer. Manufacturing of this N-terminally acetylated 28-residue...

Full description

Bibliographic Details
Main Authors:	Uli Binder, Arne Skerra
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	International Journal of Molecular Sciences
Subjects:	biobetter cancer COVID-19 drug delivery half-life extension immunostimulatory peptide
Online Access:	https://www.mdpi.com/1422-0067/22/1/124

Similar Items

Future of anti-VEGF: biosimilars and biobetters
by: Monika Kapur, et al.
Published: (2022-01-01)

Immunostimulatory photochemotherapeutic nanocapsule for enhanced colon cancer treatment
by: Liu Jie, et al.
Published: (2021-07-01)

Recombinant Peptide Production Platform Coupled with Site-Specific Albumin Conjugation Enables a Convenient Production of Long-Acting Therapeutic Peptide
by: Mijeong Bak, et al.
Published: (2020-04-01)

NK cell-mediated immunostimulatory effects of ethanol extract of Morinda citrifolia (noni) fruit
by: Haeyeop Kim, et al.
Published: (2022-08-01)

Self-assembled immunostimulatory nanosphere combined with PD-L1 to enhanced cancer chemoimmunotherapy
by: Haihui Wang, et al.
Published: (2022-11-01)

Immunostimulatory effects of marine algae extracts on in vitro antigen‐presenting cell activation and in vivo immune cell recruitment
by: Thi Len Ho, et al.
Published: (2023-10-01)

OPTIMIZATION OF POLYSACCHARIDE-RICH FRACTIONATION FROM MORINDA CITRIFOLIA L. FRUIT BASED ON IMMUNOSTIMULATORY EFFECT IN VITRO
by: Ediati Sasmito, et al.
Published: (2015-05-01)

Enhancement of the Immunostimulatory Effect of Phosphodiester CpG Oligodeoxynucleotides by an Antiparallel Guanine-Quadruplex Structural Scaffold
by: Fika Ayu Safitri, et al.
Published: (2021-11-01)

Finding the Right Heavy Chains for Immunostimulatory Antibodies
by: Pierre Boulard, et al.
Published: (2022-09-01)

The traditional use, structure, and immunostimulatory activity of bioactive polysaccharides from traditional Chinese root medicines: A review
by: Surina Bo, et al.
Published: (2024-01-01)

Influence of the Composition of Cationic Liposomes on the Performance of Cargo Immunostimulatory RNA
by: Ali Bishani, et al.
Published: (2023-08-01)

Antiviral and immunostimulatory effects of Ssanti-Covir, a mixed herbal formulation, in cyclophosphamide-treated mice
by: Minh-Nhut Pham, et al.
Published: (2023-12-01)

Screening and Probiotic Properties of Lactic Acid Bacteria with Potential Immunostimulatory Activity Isolated from Kimchi
by: Jaekoo Lee, et al.
Published: (2022-12-01)

Structural Characteristics, Antioxidant, and Immunostimulatory Activities of an Acidic Polysaccharide from Raspberry Pulp
by: Yongjing Yang, et al.
Published: (2022-07-01)

Effects of various degrees of esterification on antioxidant and immunostimulatory activities of okra pectic-polysaccharides
by: Wei Li, et al.
Published: (2022-10-01)

Antioxidant and Immunostimulatory Activities of a Submerged Culture of <i>Cordyceps sinensis</i> Using Spent Coffee
by: Sung Hee Han, et al.
Published: (2021-07-01)

Research on Extraction, Structure Characterization and Immunostimulatory Activity of Cell Wall Polysaccharides from <i>Sparassis latifolia</i>
by: Jing Liu, et al.
Published: (2022-01-01)

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma
by: Yang Liu, et al.
Published: (2024-02-01)

Glycan Profile Analysis of Engineered Trastuzumab with Rationally Added Glycosylation Sequons Presents Significantly Increased Glycan Complexity
by: Esteban Cruz, et al.
Published: (2021-10-01)

Encapsulation of Asparaginase as a Promising Strategy to Improve In Vivo Drug Performance
by: Francisca Villanueva-Flores, et al.
Published: (2021-11-01)

Purification and Structural Characterization of Polysaccharides from <i>Polygonum multiflorum</i> Thunb. and Their Immunostimulatory Activity in RAW264.7 Cells
by: Yan Gou, et al.
Published: (2024-03-01)

Immunostimulatory Effects of Polysaccharides from <i>Spirulina platensis</i> In Vivo and Vitro and Their Activation Mechanism on RAW246.7 Macrophages
by: Xueyan Wu, et al.
Published: (2020-10-01)

Immunostimulatory activity of Paeonia lactiflora through TLR4-dependent activation of p38, JNK, and ERK1/2 in mouse macrophages, RAW264.7 cells
by: Min Yeong Choi, et al.
Published: (2023-12-01)

Immunostimulatory Potential of Extracellular Vesicles Isolated from an Edible Plant, <i>Petasites japonicus</i>, via the Induction of Murine Dendritic Cell Maturation
by: Jeong Moo Han, et al.
Published: (2021-09-01)

Structural characterization and immunostimulatory activity of a water-soluble polysaccharide from abalone (Haliotis discus hannai Ino) muscle
by: Linfan Shi, et al.
Published: (2023-03-01)

Comparison of Physicochemical Characteristics and Macrophage Immunostimulatory Activities of Polysaccharides from <i>Chlamys farreri</i>
by: Fulin Shi, et al.
Published: (2020-08-01)

Innovative approaches to biologic development on the trail of CT-P13: biosimilars, value-added medicines, and biobetters
by: HoUng Kim, et al.
Published: (2021-01-01)

Synergistic Immunostimulatory Activities of Probiotic Strains, <i>Leuconostoc lactis</i> and <i>Weissella cibaria</i>, and the Prebiotic Oligosaccharides They Produce
by: Seoyoung Jeong, et al.
Published: (2023-05-01)

Supplementation with a Natural Source of Amino Acids, Sil-Q1 (Silk Peptide), Enhances Natural Killer Cell Activity: A Redesigned Clinical Trial with a Reduced Supplementation Dose and Minimized Seasonal Effects in a Larger Population
by: Jung Min Cho, et al.
Published: (2021-08-01)

Beneficial immunostimulatory effect of short-term <it>Chlorella</it> supplementation: enhancement of <it>Natural Killer</it> cell activity and early inflammatory response (Randomized, double-blinded, placebo-controlled trial)
by: Kwak Jung, et al.
Published: (2012-07-01)

Immunostimulatory effect of egg yolk phosvitin phosphopeptides produced by high-temperature and mild-pressure pretreatment and enzyme combinations in RAW 264.7 cells via TLR2/MAPK signaling pathway
by: Ji-Eun Lee, et al.
Published: (2022-11-01)

Evaluation of immunomodulatory potential of probiotic conditioned medium on murine macrophages
by: Mohammad A. A. Al-Najjar, et al.
Published: (2024-03-01)

POSSIBILITIES OF IMMUNOSTIMULATING THERAPY IN RESPIRATORY INFECTIONS OF UPPER RESPIRATORY TRACTS
by: V. M. Svistushkin, et al.
Published: (2017-05-01)

An immunoregulator nanomedicine approach for the treatment of tuberculosis
by: Luona Yang, et al.
Published: (2023-05-01)

Engineered Human Heavy-Chain Ferritin with Half-Life Extension and Tumor Targeting by PAS and RGDK Peptide Functionalization
by: Shuang Yin, et al.
Published: (2021-04-01)

Immunostimulatory Activity of <i>Lactococcus lactis</i> subsp. <i>lactis</i> CAB701 Isolated from Jeju Cabbage
by: Huijin Jeong, et al.
Published: (2023-06-01)

Cell-permeable bone morphogenetic protein 2 facilitates bone regeneration by promoting osteogenesis
by: Mingu Kang, et al.
Published: (2024-04-01)

Comparative efficacy and safety of subcutaneous infliximab and vedolizumab in patients with Crohn’s disease and ulcerative colitis included in randomised controlled trials
by: Laurent Peyrin‐Biroulet, et al.
Published: (2024-03-01)

Immunostimulatory Effects of Chitooligosaccharides on RAW 264.7 Mouse Macrophages via Regulation of the MAPK and PI3K/Akt Signaling Pathways
by: Yue Yang, et al.
Published: (2019-01-01)

In Vitro Immunostimulating Activity of Sulfated Polysaccharides from <i>Caulerpa cupressoides</i> Var. <i>Flabellata</i>
by: Jefferson da Silva Barbosa, et al.
Published: (2019-02-01)