Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review
Advancement in the development of molecular sequencing platforms has identified infectious bacteria or viruses that trigger the dysregulation of a set of genes inducing the epithelial–mesenchymal transition (EMT) event. EMT is essential for embryogenesis, wound repair, and organ development; meanwhi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/12/2964 |
| _version_ | 1797489137939382272 |
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| author | Ishita Gupta Shona Pedersen Semir Vranic Ala-Eddin Al Moustafa |
| author_facet | Ishita Gupta Shona Pedersen Semir Vranic Ala-Eddin Al Moustafa |
| author_sort | Ishita Gupta |
| collection | DOAJ |
| description | Advancement in the development of molecular sequencing platforms has identified infectious bacteria or viruses that trigger the dysregulation of a set of genes inducing the epithelial–mesenchymal transition (EMT) event. EMT is essential for embryogenesis, wound repair, and organ development; meanwhile, during carcinogenesis, initiation of the EMT can promote cancer progression and metastasis. Recent studies have reported that interactions between the host and dysbiotic microbiota in different tissues and organs, such as the oral and nasal cavities, esophagus, stomach, gut, skin, and the reproductive tract, may provoke EMT. On the other hand, it is revealed that certain microorganisms display a protective role against cancer growth, indicative of possible therapeutic function. In this review, we summarize recent findings elucidating the underlying mechanisms of pathogenic microorganisms, especially the microbiota, in eliciting crucial regulator genes that induce EMT. Such an approach may help explain cancer progression and pave the way for developing novel preventive and therapeutic strategies. |
| first_indexed | 2024-03-10T00:13:12Z |
| format | Article |
| id | doaj.art-8d8e3adb759a49eb93030cfa5b6d9dc5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:13:12Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8d8e3adb759a49eb93030cfa5b6d9dc52023-11-23T15:57:12ZengMDPI AGCancers2072-66942022-06-011412296410.3390/cancers14122964Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise ReviewIshita Gupta0Shona Pedersen1Semir Vranic2Ala-Eddin Al Moustafa3College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarAdvancement in the development of molecular sequencing platforms has identified infectious bacteria or viruses that trigger the dysregulation of a set of genes inducing the epithelial–mesenchymal transition (EMT) event. EMT is essential for embryogenesis, wound repair, and organ development; meanwhile, during carcinogenesis, initiation of the EMT can promote cancer progression and metastasis. Recent studies have reported that interactions between the host and dysbiotic microbiota in different tissues and organs, such as the oral and nasal cavities, esophagus, stomach, gut, skin, and the reproductive tract, may provoke EMT. On the other hand, it is revealed that certain microorganisms display a protective role against cancer growth, indicative of possible therapeutic function. In this review, we summarize recent findings elucidating the underlying mechanisms of pathogenic microorganisms, especially the microbiota, in eliciting crucial regulator genes that induce EMT. Such an approach may help explain cancer progression and pave the way for developing novel preventive and therapeutic strategies.https://www.mdpi.com/2072-6694/14/12/2964microbiotagutepithelial–mesenchymal transitiondysbiosiscancer |
| spellingShingle | Ishita Gupta Shona Pedersen Semir Vranic Ala-Eddin Al Moustafa Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review Cancers microbiota gut epithelial–mesenchymal transition dysbiosis cancer |
| title | Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review |
| title_full | Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review |
| title_fullStr | Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review |
| title_full_unstemmed | Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review |
| title_short | Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review |
| title_sort | implications of gut microbiota in epithelial mesenchymal transition and cancer progression a concise review |
| topic | microbiota gut epithelial–mesenchymal transition dysbiosis cancer |
| url | https://www.mdpi.com/2072-6694/14/12/2964 |
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