Characteristics of ciliary muscle profile in high myopes measured by swept-source anterior segment optical coherence tomography.
<h4>Objective</h4>To characterize and compare the ciliary muscle thickness (CMT) between low and high myopes using swept-source anterior segment optical coherence tomography (AS-OCT).<h4>Methods</h4>Forty visually healthy young Chinese adults aged 18-25 years were divided int...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289135&type=printable |
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| author | Hiu Yin Kwok Hoi Yee Kwok Tsz Nok Ng Tsz-Wing Leung Byung Soo Kang Chea-Su Kee |
| author_facet | Hiu Yin Kwok Hoi Yee Kwok Tsz Nok Ng Tsz-Wing Leung Byung Soo Kang Chea-Su Kee |
| author_sort | Hiu Yin Kwok |
| collection | DOAJ |
| description | <h4>Objective</h4>To characterize and compare the ciliary muscle thickness (CMT) between low and high myopes using swept-source anterior segment optical coherence tomography (AS-OCT).<h4>Methods</h4>Forty visually healthy young Chinese adults aged 18-25 years were divided into two groups based on refractive errors: low myopia (n = 20, spherical-equivalent refractive error (SER) between -0.50 D to -3.00 D) and high myopia (n = 20, SER ≤ -6.00 D). Cycloplegic refractions were performed before axial length (AL) and CMT were measured using a partial coherence laser interferometer and an AS-OCT respectively. CMT was measured perpendicularly to the sclera-ciliary muscle interface at 1 mm (CMT_1), 2 mm (CMT_2), and 3 mm (CMT_3) posterior to the scleral spur, and at the location with maximal thickness (CMT_MAX).<h4>Results</h4>High myopes demonstrated thicker CMT at 2 mm (CMT_2, p = 0.035) and 3 mm (CMT_3, p = 0.003) posterior to the scleral spur, but thinner maximal CMT (CMT_MAX, p = 0.005) than low myopes. The apical CMT_1 and CMT_MAX were also thinner in high myopes than in low myopes (both p< 0.001). CMT_MAX, apical CMT_1, and apical CMT_MAX correlated directly with SER and inversely with AL; in contrast, CMT_2 and CMT_3 showed inverse correlations with SER but direct correlations with AL.<h4>Conclusion</h4>Our findings revealed significant differences in CMT between low and high myopes, with high myopes showing thicker CMT at 2 mm and 3 mm posterior to the scleral spur, but thinner maximal CMT. These results provide new evidence of the potential structural differences in ciliary muscles during myopia development and progression. |
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| format | Article |
| id | doaj.art-8d8f2b9ccdf14632978a71c67b0efaf9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-08T23:55:55Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-8d8f2b9ccdf14632978a71c67b0efaf92023-12-13T05:32:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011811e028913510.1371/journal.pone.0289135Characteristics of ciliary muscle profile in high myopes measured by swept-source anterior segment optical coherence tomography.Hiu Yin KwokHoi Yee KwokTsz Nok NgTsz-Wing LeungByung Soo KangChea-Su Kee<h4>Objective</h4>To characterize and compare the ciliary muscle thickness (CMT) between low and high myopes using swept-source anterior segment optical coherence tomography (AS-OCT).<h4>Methods</h4>Forty visually healthy young Chinese adults aged 18-25 years were divided into two groups based on refractive errors: low myopia (n = 20, spherical-equivalent refractive error (SER) between -0.50 D to -3.00 D) and high myopia (n = 20, SER ≤ -6.00 D). Cycloplegic refractions were performed before axial length (AL) and CMT were measured using a partial coherence laser interferometer and an AS-OCT respectively. CMT was measured perpendicularly to the sclera-ciliary muscle interface at 1 mm (CMT_1), 2 mm (CMT_2), and 3 mm (CMT_3) posterior to the scleral spur, and at the location with maximal thickness (CMT_MAX).<h4>Results</h4>High myopes demonstrated thicker CMT at 2 mm (CMT_2, p = 0.035) and 3 mm (CMT_3, p = 0.003) posterior to the scleral spur, but thinner maximal CMT (CMT_MAX, p = 0.005) than low myopes. The apical CMT_1 and CMT_MAX were also thinner in high myopes than in low myopes (both p< 0.001). CMT_MAX, apical CMT_1, and apical CMT_MAX correlated directly with SER and inversely with AL; in contrast, CMT_2 and CMT_3 showed inverse correlations with SER but direct correlations with AL.<h4>Conclusion</h4>Our findings revealed significant differences in CMT between low and high myopes, with high myopes showing thicker CMT at 2 mm and 3 mm posterior to the scleral spur, but thinner maximal CMT. These results provide new evidence of the potential structural differences in ciliary muscles during myopia development and progression.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289135&type=printable |
| spellingShingle | Hiu Yin Kwok Hoi Yee Kwok Tsz Nok Ng Tsz-Wing Leung Byung Soo Kang Chea-Su Kee Characteristics of ciliary muscle profile in high myopes measured by swept-source anterior segment optical coherence tomography. PLoS ONE |
| title | Characteristics of ciliary muscle profile in high myopes measured by swept-source anterior segment optical coherence tomography. |
| title_full | Characteristics of ciliary muscle profile in high myopes measured by swept-source anterior segment optical coherence tomography. |
| title_fullStr | Characteristics of ciliary muscle profile in high myopes measured by swept-source anterior segment optical coherence tomography. |
| title_full_unstemmed | Characteristics of ciliary muscle profile in high myopes measured by swept-source anterior segment optical coherence tomography. |
| title_short | Characteristics of ciliary muscle profile in high myopes measured by swept-source anterior segment optical coherence tomography. |
| title_sort | characteristics of ciliary muscle profile in high myopes measured by swept source anterior segment optical coherence tomography |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289135&type=printable |
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