Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer

Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype and is characterized by poor survival. Radiotherapy plays an important role in treating TNBC. The purpose of this study was to determine whether inhibiting the AMP-activated protein kinase (AMPK) and phosphatidylinosit...

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Bibliographic Details
Main Authors: Jeremy Johnson, Zeta Chow, Dana Napier, Eun Lee, Heidi L. Weiss, B. Mark Evers, Piotr Rychahou
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
triple negative breast cancer
radiation
radiosensitivity
AMPK
PI3K
Online Access:https://www.mdpi.com/2073-4409/9/5/1253

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