S phase block following MEC1ATR inactivation occurs without severe dNTP depletion

S phase block following MEC1ATR inactivation occurs without severe dNTP depletion

Inactivation of Mec1, the budding yeast ATR, results in a permanent S phase arrest followed by chromosome breakage and cell death during G2/M. The S phase arrest is proposed to stem from a defect in Mec1-mediated degradation of Sml1, a conserved inhibitor of ribonucleotide reductase (RNR), causing a...

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Bibliographic Details
Main Authors: Caroline Earp, Samuel Rowbotham, Gábor Merényi, Andrei Chabes, Rita S. Cha
Format: Article
Language:English
Published: The Company of Biologists 2015-12-01
Series:Biology Open
Subjects:
Mec1
ATR
Sml1
RNR
dNTP
DNA replication
Replication arrest
Online Access:http://bio.biologists.org/content/4/12/1739

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