Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil
(1) Background: Virgin olive oil (VOO) has attracted the attention of many researchers due to its nutritional and medicinal values. However, VOO’s biological applications have been limited due to a lack of precise chemical profiling and approach to increase the physicochemical characteristics, bioac...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/7/1319 |
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| author | Ali M. Nasr Salama M. Aboelenin Mohammad Y. Alfaifi Ali A. Shati Serag Eldin I. Elbehairi Reda F. M. Elshaarawy Nashwa H. Abd Elwahab |
| author_facet | Ali M. Nasr Salama M. Aboelenin Mohammad Y. Alfaifi Ali A. Shati Serag Eldin I. Elbehairi Reda F. M. Elshaarawy Nashwa H. Abd Elwahab |
| author_sort | Ali M. Nasr |
| collection | DOAJ |
| description | (1) Background: Virgin olive oil (VOO) has attracted the attention of many researchers due to its nutritional and medicinal values. However, VOO’s biological applications have been limited due to a lack of precise chemical profiling and approach to increase the physicochemical characteristics, bioactivity, and delivery of its bioactive components; (2) Methods: The current study intended to evaluate the chemical composition of VOO using the GC-MS technique and determine its major components. Furthermore, the effect of incorporating VOO into Tween 80-lecithin nanoemulsion (OONE) and a quaternized trimethyl chitosan-thiol (TMCT) hydrogel-thickened nanoemulsion system (OOHTN) on its physicochemical characteristics and biological potentials will be investigated; (3) Results: The VOO-based NEs’ physicochemical properties (particle size and zeta potential) were steady during storage for four weeks owing to the inclusion of the protective TMCT hydrogel network to OONE. Excessive fine-tuning of olive oil nanoemulsion (OONE) and the TMCT protective network’s persistent positive charge have contributed to the oil’s improved antimicrobial, anti-biofilm, and antioxidant potentials; (4) Conclusions: The Tween 80-lecithin-TMCT nanosystem might provide a unique and multifunctional nanoplatform for efficient topical therapy as well as the transdermal delivery of lipophilic bioactive compounds. |
| first_indexed | 2024-03-09T06:04:29Z |
| format | Article |
| id | doaj.art-8d92bf8bf40342f4bb16dcf2c380955e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T06:04:29Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8d92bf8bf40342f4bb16dcf2c380955e2023-12-03T12:05:57ZengMDPI AGPharmaceutics1999-49232022-06-01147131910.3390/pharmaceutics14071319Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive OilAli M. Nasr0Salama M. Aboelenin1Mohammad Y. Alfaifi2Ali A. Shati3Serag Eldin I. Elbehairi4Reda F. M. Elshaarawy5Nashwa H. Abd Elwahab6Department of Pharmaceutics, Faculty of Pharmacy, Port Said University, Port Said 42526, EgyptBiology Department, Turabah University College, Taif University, Taif 21995, Saudi ArabiaBiology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi ArabiaBiology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi ArabiaBiology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Suez University, Suez 43533, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Sinai University—Kantara Branch, Ismailia 41636, Egypt(1) Background: Virgin olive oil (VOO) has attracted the attention of many researchers due to its nutritional and medicinal values. However, VOO’s biological applications have been limited due to a lack of precise chemical profiling and approach to increase the physicochemical characteristics, bioactivity, and delivery of its bioactive components; (2) Methods: The current study intended to evaluate the chemical composition of VOO using the GC-MS technique and determine its major components. Furthermore, the effect of incorporating VOO into Tween 80-lecithin nanoemulsion (OONE) and a quaternized trimethyl chitosan-thiol (TMCT) hydrogel-thickened nanoemulsion system (OOHTN) on its physicochemical characteristics and biological potentials will be investigated; (3) Results: The VOO-based NEs’ physicochemical properties (particle size and zeta potential) were steady during storage for four weeks owing to the inclusion of the protective TMCT hydrogel network to OONE. Excessive fine-tuning of olive oil nanoemulsion (OONE) and the TMCT protective network’s persistent positive charge have contributed to the oil’s improved antimicrobial, anti-biofilm, and antioxidant potentials; (4) Conclusions: The Tween 80-lecithin-TMCT nanosystem might provide a unique and multifunctional nanoplatform for efficient topical therapy as well as the transdermal delivery of lipophilic bioactive compounds.https://www.mdpi.com/1999-4923/14/7/1319olive oilhydrogel-thickened nanoemulsionquaternized chitosan thiolantimicrobial and anti-biofilmantioxidant |
| spellingShingle | Ali M. Nasr Salama M. Aboelenin Mohammad Y. Alfaifi Ali A. Shati Serag Eldin I. Elbehairi Reda F. M. Elshaarawy Nashwa H. Abd Elwahab Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil Pharmaceutics olive oil hydrogel-thickened nanoemulsion quaternized chitosan thiol antimicrobial and anti-biofilm antioxidant |
| title | Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil |
| title_full | Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil |
| title_fullStr | Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil |
| title_full_unstemmed | Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil |
| title_short | Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil |
| title_sort | quaternized chitosan thiol hydrogel thickened nanoemulsion a multifunctional platform for upgrading the topical applications of virgin olive oil |
| topic | olive oil hydrogel-thickened nanoemulsion quaternized chitosan thiol antimicrobial and anti-biofilm antioxidant |
| url | https://www.mdpi.com/1999-4923/14/7/1319 |
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