Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer
Chemotherapy is a well-established method for treating cancer, but it has limited effectiveness due to its high dosage and harmful side effects. To address this issue, researchers have explored the use of photothermal agent nanoparticles as carriers for precise drug release in vivo. In this study, t...
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MDPI AG
2024-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/5/1042 |
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| author | Yang Lu Xinglong Liu Ting Zhao Chuanbo Ding Qiteng Ding Ning Wang Shuang Ma Lina Ma Wencong Liu |
| author_facet | Yang Lu Xinglong Liu Ting Zhao Chuanbo Ding Qiteng Ding Ning Wang Shuang Ma Lina Ma Wencong Liu |
| author_sort | Yang Lu |
| collection | DOAJ |
| description | Chemotherapy is a well-established method for treating cancer, but it has limited effectiveness due to its high dosage and harmful side effects. To address this issue, researchers have explored the use of photothermal agent nanoparticles as carriers for precise drug release in vivo. In this study, three different sizes of polydopamine nanoparticles (PDA–1, PDA–2, and PDA–3) were synthesized and evaluated. PDA–2 was selected for its optimal size, encapsulation rate, and drug loading rate. The release of the drug from PDA–2@TAX was tested at different pH and NIR laser irradiation levels. The results showed that PDA–2@TAX released more readily in an acidic environment and exhibited a high photothermal conversion efficiency when exposed to an 808 nm laser. In vitro experiments on ovarian cancer cells demonstrated that PDA–2@TAX effectively inhibited cell proliferation, highlighting its potential for synergistic chemotherapy-photothermal treatment. |
| first_indexed | 2024-04-25T00:24:33Z |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-25T00:24:33Z |
| publishDate | 2024-02-01 |
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| spelling | doaj.art-8d95fb0f987b4b3d8c635bce5ee2b1642024-03-12T16:50:52ZengMDPI AGMolecules1420-30492024-02-01295104210.3390/molecules29051042Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian CancerYang Lu0Xinglong Liu1Ting Zhao2Chuanbo Ding3Qiteng Ding4Ning Wang5Shuang Ma6Lina Ma7Wencong Liu8School of Resources and Environment, Jilin Agricultural University, Changchun 130118, ChinaSchool of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, ChinaSchool of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, ChinaSchool of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, ChinaSchool of Resources and Environment, Jilin Agricultural University, Changchun 130118, ChinaSchool of Resources and Environment, Jilin Agricultural University, Changchun 130118, ChinaSchool of Resources and Environment, Jilin Agricultural University, Changchun 130118, ChinaSchool of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, ChinaSchool of Resources and Environment, Jilin Agricultural University, Changchun 130118, ChinaChemotherapy is a well-established method for treating cancer, but it has limited effectiveness due to its high dosage and harmful side effects. To address this issue, researchers have explored the use of photothermal agent nanoparticles as carriers for precise drug release in vivo. In this study, three different sizes of polydopamine nanoparticles (PDA–1, PDA–2, and PDA–3) were synthesized and evaluated. PDA–2 was selected for its optimal size, encapsulation rate, and drug loading rate. The release of the drug from PDA–2@TAX was tested at different pH and NIR laser irradiation levels. The results showed that PDA–2@TAX released more readily in an acidic environment and exhibited a high photothermal conversion efficiency when exposed to an 808 nm laser. In vitro experiments on ovarian cancer cells demonstrated that PDA–2@TAX effectively inhibited cell proliferation, highlighting its potential for synergistic chemotherapy-photothermal treatment.https://www.mdpi.com/1420-3049/29/5/1042PDAphotothermal agent nanoparticlesTAXovarian cancer |
| spellingShingle | Yang Lu Xinglong Liu Ting Zhao Chuanbo Ding Qiteng Ding Ning Wang Shuang Ma Lina Ma Wencong Liu Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer Molecules PDA photothermal agent nanoparticles TAX ovarian cancer |
| title | Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer |
| title_full | Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer |
| title_fullStr | Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer |
| title_full_unstemmed | Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer |
| title_short | Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer |
| title_sort | synthesis of taxifolin loaded polydopamine for chemo photothermal synergistic therapy of ovarian cancer |
| topic | PDA photothermal agent nanoparticles TAX ovarian cancer |
| url | https://www.mdpi.com/1420-3049/29/5/1042 |
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