Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ<i>dtlA</i> Mutant of a Marine-Derived <i>Streptomyces</i> Strain
Two new dimeric cinnamoyl lipids (CL) featuring with an unusual dearomatic carbon-bridge, named youssoufenes A2 (<b>1</b>) and A3 (<b>2</b>), were isolated from the Δ<i>dtlA</i> mutant strain of marine-derived <i>Streptomyces youssoufiensis</i> OUC6819...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/20/6/394 |
| Summary: | Two new dimeric cinnamoyl lipids (CL) featuring with an unusual dearomatic carbon-bridge, named youssoufenes A2 (<b>1</b>) and A3 (<b>2</b>), were isolated from the Δ<i>dtlA</i> mutant strain of marine-derived <i>Streptomyces youssoufiensis</i> OUC6819. Structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses, and their absolute configurations were determined by combination of the long-range NOE-based <sup>1</sup>H-<sup>1</sup>H distance measurements and ECD calculations. Compounds <b>1</b> and <b>2</b> exhibited moderate growth inhibition against multi-drug-resistant <i>Enterococcus faecalis</i> CCARM 5172 with an MIC value of 22.2 μM. |
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| ISSN: | 1660-3397 |